Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.     

具有4l条边图的边共色数的一个上界

提出与共着色相对应的边共着色的概念，并给出了具有4^ι条边的图的边共色数的一个上界．     

氧化物陶瓷与Ag－Cu－Ti钎料的界面反应

研究了氧化铝和氧化铬陶瓷真空钎焊时陶瓷与Ａｇ－Ｃｕ－Ｔｉ钎料合金的界面反应，分析了加热温度（１０７３～１３２３Ｋ）和保温时间（０～３．６ｋｓ）对界面反应的影响规律，扫描电镜和Ｘ射线衍射分析结果表明：两种陶瓷均与Ａｇ－Ｃｕ－Ｔｉ合金发生反应，反应层厚度随着温度和时间的增加而增加，对于氧化铝陶瓷，低子１１２３Ｋ时，反应产物为Ｃｕ２Ｔｉ４Ｏ和ＡｌＴｉ；在１１７３Ｋ以上温度时反应产物则为Ｔｉ２Ｏ、ＴｉＯ和ＣｕＴｉ２，此时，反应层是按Ａｌ２Ｏ３／Ｔｉ２Ｏ＋Ｔｉ０／Ｔｉ２Ｏ＋ＴｉＯ＋ＣｕＴｉ２／ＣｕＴｉ２／Ａｇ－Ｃｕ呈层状过渡分布，对于氧化锆陶瓷，在整个试验温度范围，反应产物均为γ－ＡｇＴｉ３和δ－ＴｉＯ，反应产物也是按ＺｒＯ２／δ－ＴｉＯ／δ－ＴｉＯ＋γ－ＡｇＴｉ３／γ－ＡｇＴｉ３／Ａｇ－Ｃｕ呈层状过渡分布的．     

Maxwell方程组与电磁量的微分形式

通过考虑电磁量的几何特性，引入微分形式的概念。指出用微分形式描述电磁量的优越性。在此基础上给出用微分形式表述的Ｍａｘｗｅｌｌ方程组。     

级联正交／PN码直扩系统在相关衰落信道下的性能

分析了级联正交／长PN码的互相关和自相关特性。分析的结果用来计算在这种新的扩频方案下直接扩频系统在多用户和多径衰落下的系统性能。多径衰落信道为相关Nakagami信道。接收端采用最大比率分集接收机。     

我国企业技术创新行为及影响因素研究

从企业利益驱动和投入拉动两个层面探讨了企业技术创新的动力,发现R&D人员数量、经费投入、新产品产值和对外出口额对不同类型的高新技术企业产生的技术创新推动效应存在显著差异;拥有专利发明数整体上看对大多数类型企业的创新推动力显著为正。     

低糖型金耳饮料口感调配研究初探

以金耳发酵液为主要原料，用木糖醇和低聚异麦芽糖作甜味剂，柠檬酸为酸味剂制成低糖型金耳饮料并进行口感调配。经正交试验，当添加木糖醇5．0％、低聚异麦芽糖3．5％、柠檬酸0．10％时产品口感较佳。且还原糖含量仅为0．52％。     

NMR实现量子通讯中时间交集问题的一个方案

量子通讯中的时间交集问题可表述如下:处于不同地点的2个人Alice和Bob,各有自己的时间表,分别构成集合A与B,不妨设两集合都含有N个元素,2人要通过通讯来约定共同的时间,怎样能使交换的信息最少.     

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population

Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors. We performed a genome-wide association study of atopic dermatitis in a Chinese Han population using 1,012 affected individuals (cases) and 1,362 controls followed by a replication study in an additional 3,624 cases and 12,197 controls of Chinese Han ethnicity, as well as 1,806 cases and 3,256 controls from Germany. We identified previously undescribed susceptibility loci at 5q22.1 (TMEM232 and SLC25A46, rs7701890, P(combined) = 3.15 × 10(-9), odds ratio (OR) = 1.24) and 20q13.33 (TNFRSF6B and ZGPAT, rs6010620, P(combined) = 3.0 × 10(-8), OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, P(combined) = 5.90 × 10(-12), OR = 0.82) in the Chinese sample. The 20q13.33 locus also showed evidence for association in the German sample (rs6010620, P = 2.87 × 10(-5), OR = 1.25). Our study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis.     

冰箱压缩机噪声分析及降噪措施的研究

采用频谱分析技术，研究了ＱＤ５５Ａ冰箱压缩主要噪声来源，提出了以减少压缩机气流脉动性噪声为主的降噪措施，经批量生产测试验证，噪声下降４ｄＢ。