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11.
Summary A series of new substituted indole derivatives was prepared, all of which were distinguished by sympathicolytic activity.
A number of these substances, mainly those from the group of indoline derivatives, have a hypotensive action. Others, especially
those from the group of indole derivatives, have a hypertensive action.
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Andäng M Hjerling-Leffler J Moliner A Lundgren TK Castelo-Branco G Nanou E Pozas E Bryja V Halliez S Nishimaru H Wilbertz J Arenas E Koltzenburg M Charnay P El Manira A Ibañez CF Ernfors P 《Nature》2008,451(7177):460-464
Stem cell self-renewal implies proliferation under continued maintenance of multipotency. Small changes in numbers of stem cells may lead to large differences in differentiated cell numbers, resulting in significant physiological consequences. Proliferation is typically regulated in the G1 phase, which is associated with differentiation and cell cycle arrest. However, embryonic stem (ES) cells may lack a G1 checkpoint. Regulation of proliferation in the 'DNA damage' S/G2 cell cycle checkpoint pathway is known for its role in the maintenance of chromatin structural integrity. Here we show that autocrine/paracrine gamma-aminobutyric acid (GABA) signalling by means of GABA(A) receptors negatively controls ES cell and peripheral neural crest stem (NCS) cell proliferation, preimplantation embryonic growth and proliferation in the boundary-cap stem cell niche, resulting in an attenuation of neuronal progenies from this stem cell niche. Activation of GABA(A) receptors leads to hyperpolarization, increased cell volume and accumulation of stem cells in S phase, thereby causing a rapid decrease in cell proliferation. GABA(A) receptors signal through S-phase checkpoint kinases of the phosphatidylinositol-3-OH kinase-related kinase family and the histone variant H2AX. This signalling pathway critically regulates proliferation independently of differentiation, apoptosis and overt damage to DNA. These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway. 相似文献
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师永 《科技情报开发与经济》2002,12(5):141-142
针对传统的成本控制管理模式的弊端,太原铁路分局太原水电段研制成功了利用计算机网络和磁卡技术,对成本支出的各个项目进行实时控制的管理系统,实现了成本控制的动态管理,为企业合理安排资金流向提供了科学的依据。 相似文献
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提出与共着色相对应的边共着色的概念,并给出了具有4^ι条边的图的边共色数的一个上界. 相似文献
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氧化物陶瓷与Ag-Cu-Ti钎料的界面反应 总被引:4,自引:0,他引:4
研究了氧化铝和氧化铬陶瓷真空钎焊时陶瓷与Ag-Cu-Ti钎料合金的界面反应,分析了加热温度(1073~1323K)和保温时间(0~3.6ks)对界面反应的影响规律,扫描电镜和X射线衍射分析结果表明:两种陶瓷均与Ag-Cu-Ti合金发生反应,反应层厚度随着温度和时间的增加而增加,对于氧化铝陶瓷,低子1123K时,反应产物为Cu2Ti4O和AlTi;在1173K以上温度时反应产物则为Ti2O、TiO和CuTi2,此时,反应层是按Al2O3/Ti2O+Ti0/Ti2O+TiO+CuTi2/CuTi2/Ag-Cu呈层状过渡分布,对于氧化锆陶瓷,在整个试验温度范围,反应产物均为γ-AgTi3和δ-TiO,反应产物也是按ZrO2/δ-TiO/δ-TiO+γ-AgTi3/γ-AgTi3/Ag-Cu呈层状过渡分布的. 相似文献
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王锦彪 《西北师范大学学报(自然科学版)》1994,30(1):31-33
在线帮助信息的直接获取及序号自动生成是G4707系统的主要特点.由于前台为汉字信息,代码隐入后台,故用户界面友好. 相似文献
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李红星 《河北省科学院学报》2015,(1):64-68
2010~2011年对赤霞珠葡萄适宜留梢量进行了研究。结果表明:留梢量对赤霞珠葡萄枝叶生长、果实发育、品质形成等有较大影响。适当多留梢有利于产量的提高,但使品质下降;适当少留梢有利于提高浆果品质。综合比较认为:赤霞珠葡萄每m2架面留结果梢15个较适宜。 相似文献
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基于数字化共轭曲面理论的数字齿面共轭求解 总被引:4,自引:0,他引:4
基于数字化共轭曲面理论和方法,根据啮合传动的规律,应用自行研制开发的共轭曲面求解软件Conjugater1.0.对直齿面和鼓形齿面的数字化共轭曲面求解分别进行了研究.可为各种齿轮的数字化啮合分析、模拟仿真以及数字加工技术提供理论和技术分析参考. 相似文献