Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.     

芦岭矿采空区煤炭自燃发火与开采技术关系的试验研究

采用了包括多点热电偶测定采空区遗煤温度、应用六氟化硫气体示踪和测定漏风压差等综合技术手段研究分析了漏风分布规律。结果发现,遗煤温度变化受漏风温度和漏风强度影响较大;停采线漏风的量及漏风时间受主要进、回风道的布置以及采掘接替安排的影响。由于采用无煤柱开采技术,三个相邻阶段的采空区之间连通,存在漏风,最后又从开采技术上提出了防火措施。     

The melatonin rhythm: both a clock and a calendar

The paper briefly reviews the data which shows that the circadian production and secretion of melatonin by the pineal gland can impart both daily, i.e., clock, and seasonal, i.e., calendar, information to the organism. The paper summarizes the 3 patterns of nocturnal melatonin production that have been described. Clearly, regardless of the pattern of nocturnal melatonin production a particular species normally displays, the duration of nightime elevated melatonin is proportional to the duration of the night length. Since daylength under natural conditions changes daily the melatonin rhythm, which adjusts to the photoperiod sends time of year information to the organism. The melatonin receptors which subserve the clock message sent by the pineal gland in the form of a melatonin cycle may reside in the biological clock itself, namely, the suprachiasmatic nuclei (SCN). The melatonin receptors that mediate seasonal changes in reproductive physiology are presumably those that are located on the pars tuberalis cells of the anterior pituitary gland. Besides these receptors which likely mediate clock and calendar information, melatonin receptors have been described in other organs. Interestingly, the distribution of melatonin receptors is highly species-specific. Whereas the clock and calendar information that the melatonin cycle imparts to the organism relies on cell membrane receptors, a fact that is of some interest considering the high lipophilicity of melatonin, recent studies indicate that other functions of melatonin may require no receptor whatsoever.     

高原鼠兔体重生长动态数学模型之再探讨

本文用麦夸算法构造高原鼠兔体重生长的Logistic和Compertz曲线模型,其结果表明:Logistic曲线比Gompertz曲线更优化,Logistic模型比逻辑斯谛-指要饱和模型的精确度更高.     

指纹识别技术在暂住人口身份证管理系统中的应用

随着计算机技术应用的普及和指纹识别技术的日益完善,现行的暂住人口身份证管理系统已逐步呈现出许多缺点和弊端.为解决近年来出现的诸多问题,使用本文提出的指纹IC卡暂住人口身份证管理系统,可以使被查者与本人身份完全一致,能够强化暂住人口的管理.     

地下感应式通信理论的研究

本文研究了地下矿井内,电波沿巷道内线缆传播的可行性及单线波模的传播与衰减规律,研究巷道内电小天线与线缆之间的耦合情况,从而为实际工作提供理论依据。     

Catecholamine metabolism in the vas deferens and the adrenal gland with special reference to the central catecholamine-depleted state

Experiments were carried out to elucidate the role of central catecholamines in regulating catecholamine metabolism in the vas deferens and adrenal gland of the rat. Rats were injected intracerebroventricularly (i.c.v.) with either vehicle or 6-hydroxydopamine (6-OHDA). Groups of animals pretreated with vehicle or 6-OHDA (i.c.v.) were injected intraperitoneally (i.p.) with alpha-methyl-para-tyrosine (AMT), a tyrosine hydroxylase inhibitor. Catecholamine turnover rates were estimated by determining norepinephrine or epinephrine content after administrating AMT.Central norepinephrine and dopamine contents decreased significantly (p<0.05) after treatment with 6-OHDA and AMT. The norepinephrine content of the vas deferens of rats pretreated with 6-OHDA was markedly reduced (p<0.001) after administration of AMT, whereas that of the vehicle-treated rats remained unchanged. Administration of 6-OHDA had no effect on the norepinephrine or epinephrine content of the adrenal gland.The present results indicate that central monoaminergic neurons have an inhibitory effect on the adrenergic neurons of the vas deferens. In contrast, this inhibitory regulation does not appear to be exerted on the adrenal glands.     

分块三级及矢量量化图像编码

本文提出了一种新的称为分块三级及矢量量化图像压缩编码方法。该方法是以分块截断编码技术和矢量量化技术为基础的编码方法。对两幅512×512×8静态测试图像进行的计算机模拟实验表明:平均编码率低于0.91比特/像素,即图像数据压缩比大于8.8倍,而信噪比不低于37dB,复原图像的主观质量较好。     

利福平菌丝体厌氧生化处理的研究

制药厂生产利福平过程中产生大量的利福平菌丝体,可严重污染环境。用厌氧消化法处理利福平菌丝体,消化温度40℃,反应器容积负荷2KgCOD/m~3·d,液料滞留期(SRT)14～20天,取得了良好的处理效果。COD去除率稳定在90％左右,BOD_5去除率达到95％以上,产气率达到0.49m~3/去除KgCOD。     

中国南海海绵化学成份研究Ⅱ—B·C

从中国南海西沙群岛永胜岛附近海域采集到的一种海绵(种属未定)分离到两种新的三羟基长链酰胺类化合物S—Ⅱ(C_(49)H_(99)NO_4,M=765,m.p.138-140℃)和S—Ⅲ(C_(45)H_(93)NO_4,M=723,m.p.92—93℃),通过对它们的IR,MS,~1HNMR,~(13)CNMR及~(13)CNMR DEPT等波谱数据分析,S—Ⅱ和S—Ⅲ的结构分别确定为N-(1-乙基-3,22-二羟基)二十二烷基-2-甲基-4-羟基二十四脂肪酸酰胺和N-(1-羟甲基-2-乙基-4-甲基-3,18-二羟基)十九烷基—二十三脂肪酸酰胺。