劣质绝缘子电场正问题优化算法分析

针对劣化绝缘子的电场法检测中绝缘子电场计算精度低的问题,提出基于遗传算法优化的模拟电荷法进行高压静电场计算,给出了优化方法原理、可行性分析,建立了绝缘子电场计算目标函数及优化模型,并进行了绝缘子串周围电场的计算分析.分析结果表明,将绝缘子串周围检测点电位作为目标函数,应用遗传算法优化模拟电荷的电荷量,可更好地对目标函数进行全局寻优,提高了模拟电荷法的寻优速度、绝缘子串周围电场的计算精度以及绝缘子串中劣质绝缘子诊断的准确度.     

园林植保工作不容忽视

园林植物病虫害是制约园林绿化事业可持续发展的重要因素之一。分析了近年来太原市病虫害发生和危害趋重的原因，针对太原市园林植保工作中存在的问题。提出防治病虫害、搞好植保工作的措施和建议。     

Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

Summary Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K⁺ (35 mM) and amphetamine (50 M) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.     

中心龙卷流型搅拌槽实验研究I

介绍一种新型高效节能搅拌设备——中心龙卷流型搅拌槽。阐述了中心龙卷流型搅拌槽的流场形成机理，给出了该搅拌槽在Re>10     

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

In most eukaryotes, poly(ADP-ribose) polymerase (PARP) recognizes DNA strand interruptions generated in vivo. DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends. Studies on the effects of the disruption of the gene encoding PARP (Adprt1, formerly Adprp) in mice have demonstrated roles for PARP in recovery from DNA damage and in suppressing recombination processes involving DNA ends. Telomeres are the natural termini of chromosomes and are, therefore, potential targets of PARP. Here, by the use of two different techniques, we show that mice lacking PARP display telomere shortening compared with wild-type mice. Telomere shortening is seen in different genetic backgrounds and in different tissues, both from embryos and adult mice. In vitro telomerase activity, however, is not altered in Adprt1-/- mouse fibroblasts. Furthermore, cytogenetic analysis of mouse embryonic fibroblasts reveals that lack of PARP is associated with severe chromosomal instability, characterized by increased frequencies of chromosome fusions and aneuploidy. The absence of PARP does not affect the presence of single-strand overhangs, naturally present at the ends of telomeres. This study therefore reveals an unanticipated role for PARP in telomere length regulation and provides insights into its functions in maintaining genomic integrity.     

Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism.

Somatic mosaicism due to reversion of a pathogenic allele to wild type has been described in several autosomal recessive disorders. The best known mechanism involves intragenic mitotic recombination or gene conversion in compound heterozygous patients, whereby one allele serves to restore the wild-type sequence in the other. Here we document for the first time functional correction of a pathogenic microdeletion, microinsertion and missense mutation in homozygous Fanconi anaemia (FA) patients resulting from compensatory secondary sequence alterations in cis. The frameshift mutation 1615delG in FANCA was compensated by two additional single base-pair deletions (1637delA and 1641delT); another FANCA frameshift mutation, 3559insG, was compensated by 3580insCGCTG; and a missense mutation in FANCC(1749T-->G, Leu496Arg) was altered by 1748C-->T, creating a cysteine codon. Although in all three cases the predicted proteins were different from wild type, their cDNAs complemented the characteristic hypersensitivity of FA cells to crosslinking agents, thus establishing a functional correction to wild type.     

新疆西天山典型岩石含矿性研究

通过对新疆西天山四种典型岩石类型的岩石学特征和含矿性分析 ,认为糜棱岩中相对富集金、银、铜 ,并且砷也较富 ,在区域寻找金、银、铜矿方面有较大的指导意义。火山碎屑岩对金、铜等成矿有利 ,但此类岩石中铜、金分布存在不均匀性 ,在一些具褐铁矿化、黄铁矿化、硅化、绿泥石化等现象的韧性剪切带 ,极可能呈富矿层位 ,这类岩石应是该区寻找铜金矿床的主要岩石类型     

转基因鱼生态效应的评价

转基因鱼的优良经济性状为水产业提供了巨大的发展潜力，但转基因鱼释放到自然环境后的生态效应则引起了很多争议。文章分析了转基因鱼的生态风险，并讨论了特洛伊基因效应模型。考虑到环境中各个生态因子对生物体表型的影响，生态学家在对转基因鱼进行生态风险的评价时，不能仅仅依赖于实验室的研究和理论模型，而需要建立人工模拟生态系统，从而得到全面、可靠的结论。     

SOD与酪氨酸酶共存时各自的活性

本文采用NBT(氮兰四唑)光还原法,测定了在酪氨酸酶存在下SOD酶的活性,并采用生成DOPA红的方法测定了SOD酶存在下酪氨酸酶的活性.并做了一系列干扰实验,实验结果指出:在酪氨酸酶存在下SOD催化O_2~??+O_2~??+2H~+??H_2O_2+O_2的反应活性降低,而在SOD存在下酪氨酸酶催化DOPA生成DOPA红的反应有明显抑制作用.     

大旅游视野中的休闲产业

大旅游概念具有三个方面的含义:强调旅游就业的作用、提高旅游服务质量和文化内涵、"旅游—旅游休闲—休闲旅游—休闲"是旅游业发展的客观规律。因而,休闲产业的崛起是自然而然的事,并不依人的意志为转移。传统的旅游业要发展,要顺应时代潮流,就必须拓展它的外延和丰富它的内涵,在此过程中,休闲产业将大有作为。