高压静电果蔬保鲜机理分析

本对高压静电场果蔬保鲜机理进行了较为深入的分析,认为果蔬受高压静电场的作用,吸收了场能,改变了果蔬内部的能量分布,导致细胞膜电势发生变化;同时,高压电场电离周围空气产生Ｏ３,利用Ｏ３杀菌和分解果蔬中产生的乙烯的作用,破坏果蔬的后熟条件;另外,高压静电场的作用降低了苹果中生物酶的活性,使其呼吸代谢活动受到抑制,从而有效的保存水分达到保鲜效果。     

Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1

Maternal stress during pregnancy is prevailing worldwide,which exposes fetuses to intrauterine hyper glucocorticoids (GC),programming offspring to obesity and m...     

Comparison of breeding biology aspects of Fluvicola nengeta (Aves: Tyrannidae) between two nesting sites

Fluvicola nengeta is an insectivorous bird that belongs to the Tyrannidae family, which lives close to bodies of water and can occur in urban areas as well. It makes use of natural and man-made substrates to build its nests. This study aims at describing the reproductive biology of F. nengeta by comparing nests built on vegetation and man-made structures as to their shapes, nest dimensions, building materials, distance from bodies of water and reproductive success. Forty-four nests were found, where 30 were located in vegetation and 14 on man-made structures. Nests did not exhibit any single pattern and were divided into three distinct shapes: closed/globular/base; closed/ovoid/base (45.5%; n = 5 for both) and low cup/base (9%; n = 1). Nests built on man-made structures exhibited a larger amount of anthropic material, such as plastic and paper, instead of plant-derived materials. Nests on man-made structures were found to be higher up from the ground (459.8 ± 46.9 m) and farther from water (232.9 ± 54.8 m) in comparison to those on vegetation (92.2 ± 28.6 m and 7.3 ± 4.7 m, respectively), aside from exhibiting a higher Mayfield reproductive success (37%) when compared to nests built on vegetation (34%). The estimated values of the daily survival rate (DSR) for vegetation nests were 0.997 for the incubation period and 0.928 for the nestling period. In man-made structure nests, DSRs were 0.968 and 0.964, respectively, during the incubation and nestling periods. The period survival rate (PSR) of nests in vegetation was significantly higher than the PSRs of nests in man-made structures during the incubation period. DSRs did not differ between incubation and nestling periods for either nesting sites.     

Epistemic benefits of the material theory of induction

C. D. Broad famously labelled the problem of providing our inductive practices with a proper justification “the scandal of philosophy” (Broad, 1952). Recently, John Norton has provided a dissolution of this problem (2014). According to Norton, inductive inference is grounded in particular facts obtaining within particular domains (J. Norton, 2003b, 2010, 2014). Because the material theory does not involve a universal schema of induction, Norton claims it dissolves the problem of induction (which implies that such universal schemas cannot be justified).In this paper, I critically evaluate Norton's dissolution. In particular, I argue that the problem of induction is an epistemological problem, that Norton's material theory entails an externalist epistemology, and that it is a common feature of such epistemologies that they dissolve the problem of induction. The upshot is that the material theory is not unique in its ability to reap the specifically epistemic benefits of dissolving the problem of induction, and thus that the epistemic advantages of the material theory over extant alternatives in this regard are fewer than it may appear at first sight.     

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endotoxin-induced endocytic retrieval of Toll-like receptor 4 (TLR4) in human macrophages. Depletion of CDC50A, the β-subunit that is crucial for the activity of multiple P4-ATPases, resulted in endotoxin-induced hypersecretion of proinflammatory cytokines, enhanced MAP kinase signaling and constitutive NF-κB activation. In addition, CDC50A-depleted THP-1 macrophages displayed reduced tolerance to endotoxin. Moreover, endotoxin-induced internalization of TLR4 was strongly reduced and coincided with impaired endosomal MyD88-independent signaling. The phenotype of CDC50A-depleted cells was also induced by separate knockdown of two P4-ATPases, namely ATP8B1 and ATP11A. We conclude that lipid flippases are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.