Transplantation of human cortex with Alzheimer's disease into rat occipital cortex; a model for the study of Alzheimer disease

Summary Senile dementia of the Alzheimer type (SDAT) is a major problem in the human senescent population. As this pathology cannot be reproduced in animals, research into its development is greatly impeded. The technique of implantation of the nervous tissue has been utilized in order to establish an animal model and to test the possible existence of a transmissible agent. When human temporal cortex with Alzheimer's disease is implanted in the occipital cortex of 7-week-old rats, human cerebral tissue containing abundant tangles induces in the receiver cortex a reactive fibrous gliosis. In the processes of the astrocytes, twisted filaments are evident among bundles of normal filaments. These alterations could be induced by the metabolising of abnormal filament subunits or by some infectious agent introduced by the implant.This study is supported by grant No. 2.4517.82 of Fonds de la Recherche Fondamentale Collective of Belgium.     

An assessment of the effect of hormone and neurotransmitters on adenine and gluanine derivatives simultaneously in rat brain cortical slices

Summary A 2-dimensional thin-layer method has been developed for the separation on cellulose of adenine and guanine derivatives. Using incubated rat cerebral cortex slices it was shown that noradrenaline and acetylcholine stirnulated cAMP and cGMP production respectively but glutamate and -aminobutyric acid stimulated production of both cyclic nucleotides.     

Furocaulerpin,a new acetylenic sesquiterpenoid from the green algaCaulerpa prolifera

Summary Furocaulerpin, an acetylenic sesquiterpenoid possessing a furan ring, has been isolated from the marine algaCaulerpa prolifera, and its stereostructure elucidated mainly on the basis of physico-chemical data.This work was carried out in the frame work of the Progetto Finalizzato per l'Oceanografia e i Fondi Marini, CNR, Rome. Thanks are due to the Centro di Metodologie Chimico-Fisiche of the University of Naples (Mr I. Giudicianni) for the determination of PMR-spectra.     

Proteolytic activity on endogeneous substrates in cell-free extracts ofTrypanosoma cruzi

Summary Cell-free extracts ofTrypanosoma cruzi contain proteolytic activity able to degrade endogenous substrates. The activity was maximal at pH 3 to 4, had an optimal temperature of 65°C, and was strongly inhibited by N--p-tosyl-L-lysine chloromethyl ketone.This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, the Fundación Julio Cherny, and the Ministerio de Salud Pública y Medio Ambiente de la República Argentina. The authors gratefully acknowledge the technical assistance of Mr Esteban Bontempi.     

计算机辅助螺纹钢孔型设计系统的开发及应用

型钢孔型设计是制定型钢轧制工艺的重要内容之一.传统孔型设计过程以人工经验为主,其计算繁琐,原材料消耗大.为提高生产效率,通过对螺纹钢延伸孔型系统、精轧孔型系统及成品孔型的构成和设计方法的分析,结合螺纹钢孔型系统的基本设计理论和实际生产经验,对以往孔型设计过程中所使用的数学模型、经验公式等进行了修正,并以结构化程序设计方法为基础,采用可视化编程工具Visual Basic6.0建立了计算机辅助螺纹钢孔型设计系统.试用效果表明,缩短了新产品的设计周期,降低了轧机能耗和生产成本.     

电缆电视系统中的非线性失真理论研究

从理论上论述了二价失真,三阶失真、互相调制及交扰调制的产生机理,分析了影响非线性失真指标的关键因素,并给出了减小非线性失真的主要途径.     

绿脓杆菌外毒素A与Ⅱ型单纯疱疹病毒糖蛋白嵌合表达质粒的构建及其免疫原性的研究

构建外毒素结构域Ⅰ a基因(EPA103)与Ⅱ型单纯疱疹病毒糖蛋白(HSV-2-gD)嵌合蛋白表达载体(pET-EgD),得到嵌合表达蛋白.利用外毒素结构域Ⅰ a基因表达蛋白的佐剂效应,以pET-EgD表达嵌合蛋白免疫Balb/c小鼠.结果显示:嵌合表达蛋白(pET-EgD)免疫小鼠,可在小鼠体内诱导产生抗HSV-2特异性抗体.嵌合表达蛋白(pET-EgD)具有较强的免疫原性,为开发研究Ⅱ型单纯疱疹核酸疫苗奠定了基础.     

最小费用流原始-对偶算法分析

分析了原始一对偶圈算法，并补充了著名数学家Papadimitriou(1982)在其专著中的证明；此外，还增加了原始一对偶迭加算法可能出现的其它情况，这样更有利于深化对最小费用流的认识．     

激发极化法在找水中的应用

激发极化法(简称激电法)不受地形起伏及围岩电阻率不均匀性的影响。因此。利用激电法找水，特别是在山区找水受到了重视，并取得了良好的效果。介绍了激发极化现象和激电找水中的常用参数，给出了利用激电法找水的具体实例。     

电子商务税收政策的国际借鉴与思考

分析了美国与欧盟的电子商务税收政策,探讨了借鉴国际经验完善我国电子商务税收政策的方法,提出了建立、完善我国电子商务税收政策的具体措施.