基于多层等值面的电磁环境三维可视化研究

电磁环境三维可视化是目前虚拟战场环境中亟待解决的问题之一,提出多层等值面的方法来表现三维电磁环境。数据生成采用了Longley Rice电波传播模型,该模型考虑地形遮挡以及大气影响,计算生成了用频设备的三维空间电磁波强度值。为了直观表现电磁波强度在空间中的分布范围,采用多层Marching Tetrahedra(MT)等值面的方法,表现了多个不同强度大小的电磁环境分布,解决了面绘制方法在对体数据内部数据细节表现不够的缺陷。为了提高电磁环境的可视化性能,充分利用现在图形处理器(graphic processing unit, GPU)的通用计算能力,实现了硬件加速多层等值面一起提取输出的方法,降低CPU计算负荷,加快了等值面提取速度。最后实现了一个可实时交互的电磁环境三维可视化系统,实验结果表明该方法表现了用频设备在虚拟战场环境中的三维电磁态势,对于用频设备选址和无线通信规划都有一定的辅助作用。     

一种基于最小熵准则的SAR图像自聚焦算法

研究了一种新颖的SAR图像自聚焦算法。该方法从复图像域出发 ,利用最小熵准则盲解卷积原理 ,通过多维搜索完成相位误差校正。同相位梯度自聚焦算法相比 ,最小熵算法无需在图像域分离出强点目标 ,因而特别适用于无任何明显特征的图像。仿真及实测数据处理结果证明了该方法的有效性     

供应链中二级分销网络优化设计的随机规划模型

给出供应链中二级分销网络优化设计的机会约束规划模型。模型中将各个分销中心的需求量和各工厂的生产能力设为随机参数，并进一步讨论如何将模型中的机会约束转化为确定性等价类问题。     

Asymptotic limits and stabilization for the 1D nonlinear Mindlin-Timoshenko system

<正> This paper shows how the so called von Karman model can be obtained as a singular limitof a modified Mindlin-Timoshenko system when the modulus of elasticity in shear k tends to infinity,provided a regularizing term through a fourth order dispersive operator is added.Introducing dampingmechanisms,the authors also show that the energy of solutions for this modified Mindlin-Timoshenkosystem decays exponentially,uniformly with respect to the parameter k.As k→∞,the authors obtainthe damped von Karman model with associated energy exponentially decaying to zero as well.     

Retinoic acid regulates avian lung branching through a molecular network

Retinoic acid (RA) is of major importance during vertebrate embryonic development and its levels need to be strictly regulated otherwise congenital malformations will develop. Through the action of specific nuclear receptors, named RAR/RXR, RA regulates the expression of genes that eventually influence proliferation and tissue patterning. RA has been described as crucial for different stages of mammalian lung morphogenesis, and as part of a complex molecular network that contributes to precise organogenesis; nonetheless, nothing is known about its role in avian lung development. The current report characterizes, for the first time, the expression pattern of RA signaling members (stra6, raldh2, raldh3, cyp26a1, rarα, and rarβ) and potential RA downstream targets (sox2, sox9, meis1, meis2, tgfβ2, and id2) by in situ hybridization. In the attempt of unveiling the role of RA in chick lung branching, in vitro lung explants were performed. Supplementation studies revealed that RA stimulates lung branching in a dose-dependent manner. Moreover, the expression levels of cyp26a1, sox2, sox9, rarβ, meis2, hoxb5, tgfβ2, id2, fgf10, fgfr2, and shh were evaluated after RA treatment to disclose a putative molecular network underlying RA effect. In situ hybridization analysis showed that RA is able to alter cyp26a1, sox9, tgfβ2, and id2 spatial distribution; to increase rarβ, meis2, and hoxb5 expression levels; and has a very modest effect on sox2, fgf10, fgfr2, and shh expression levels. Overall, these findings support a role for RA in the proximal–distal patterning and branching morphogenesis of the avian lung and reveal intricate molecular interactions that ultimately orchestrate branching morphogenesis.     

Effect of actinomycin D on Trypanosoma cruzi

Viable metacyclic forms of T. cruzi, Y strain, treated with an adequate dose of actinomycin D (50 micrograms Act-D/ml/10(7) parasites/ml for 72 h at 28 degrees C) showed the following properties: 1) they lost their ability to replicate in culture medium, in blood and in tissues of normal mice and were no longer able to incorporate tritiated thymidine; 2) they could not penetrate into Vero cells and could not replicate inside normal macrophages; 3) they retained their immunogenicity and the ability to protect mice against a virulent infection; 4) they did not induce histological lesions as described in chronic experimental Chagas' disease.     

Toxin bioportides: exploring toxin biological activity and multifunctionality

Toxins have been shown to have many biological functions and to constitute a rich source of drugs and biotechnological tools. We focus on toxins that not only have a specific activity, but also contain residues responsible for transmembrane penetration, which can be considered bioportides—a class of cell-penetrating peptides that are also intrinsically bioactive. Bioportides are potential tools in pharmacology and biotechnology as they help deliver substances and nanoparticles to intracellular targets. Bioportides characterized so far are peptides derived from human proteins, such as cytochrome c (CYCS), calcitonin receptor (camptide), and endothelial nitric oxide synthase (nosangiotide). However, toxins are usually disregarded as potential bioportides. In this review, we discuss the inclusion of some toxins and molecules derived thereof as a new class of bioportides based on structure activity relationship, minimization, and biological activity studies. The comparative analysis of the amino acid residue composition of toxin-derived bioportides and their short molecular variants is an innovative analytical strategy which allows us to understand natural toxin multifunctionality in vivo and plan novel pharmacological and biotechnological products. Furthermore, we discuss how many bioportide toxins have a rigid structure with amphiphilic properties important for both cell penetration and bioactivity.     

一类非单调关联系统的率模可靠性分析

实际的生产和生活中存在着大量的非单调关联系统 ,对其进行可靠性分析就需要有相应的非单调关联系统理论支持 ,现有的率模 (probabilityandfuzzystate ,Profust)可靠性理论仅仅对单调关联系统进行了讨论。因此 ,首先建立了Profust非单调关联系统的相关理论 ,然后针对一类典型的非单调关联系统 (“n中取r至s”系统 )进行了具体的可靠性分析 ,从而在非单调关联系统领域对蔡的Profust可靠性理论进行了进一步的确证和推广