供应链中二级分销网络优化设计的随机规划模型

给出供应链中二级分销网络优化设计的机会约束规划模型。模型中将各个分销中心的需求量和各工厂的生产能力设为随机参数，并进一步讨论如何将模型中的机会约束转化为确定性等价类问题。     

Study of the mechanism of inhibition produced by hexoses on histamine release activity of dextran

Zusammenfassung Die Hemmung der Histaminfreisetzung durch Hexosen wurde untersucht. Es gelang, nachzuweisen bzw. graphisch darzustellen, dass ein Zusammenhang zwischen dem Prozentgehalt der Histaminfreisetzung und der Dextrankonzentration besteht, wenn nachLineweaver undBurk analysiert wurde.     

Model of the interaction between trypsin and alpha 2-macroglobulin of porcine serum]

A comparative study of the dissociation into subunits of Porcine alpha2 M, either native or bound to trypsin (Tn), has been carried out in order to determine the modifications of the alpha2 M structure due to the formation of the Tn-alpha2 M complex. Analytical ultra-centrifugation at pH 3.5 shows that the dissociation is smaller when alpha 2 M is bound to trypsin. Electrophoresis in 4% polyacrylamide gels, in presence of 0.1% SDS, of alpha2 M and Tn-alpha2 M incubated in 1% SDS leads to the same conclusion; the enzyme must stabilize the quaternay structure of alpha2 M. In presence of SDS + beta-mercaptoethanol, only a molecular weight (M.W.) 200,000 band is revealed in electrophoresis pattern of native alpha2 M. In the case of reduced Tn-alpha2 M, some other bands of M.W. 100,000, 50,000, 30,000 appear. When trypsin is inactivated by TLCK 100,000 M.W. band is present, accompanied by the 200,000 M.W. band whose intensity is function of the alpha2 M concentration. The 100,000 M.W. band appears therefore characteristic of the formation of the complex which must imply a proteolytic cleavage in the middle of the 100,000 polypeptidic chain of alpha2 M. A model of the complex is proposed in which the enzyme forms a proteic bridge between the two halves of the alpha2 M molecule.     

Formation of 5-hydroxytryptophol by blood platelets after thrombin and reserpine

Zusammenfassung In isolierten Blutplättchen von Kaninchen bewirkt Thrombin rasche und hochgradige Freisetzung von unverändertem 5-Hydroxytryptamin, welches durch weitere Inkubation sekundär teilweise zu 5-Hydroxytryptophol und 5-Hydroxyindolessigsäure umgewandelt wird. Nach Reserpin scheint hingegen ein Teil des 5-Hydroxytryptamins bereits bei seiner Freisetzung zu diesen Metaboliten abgebaut zu werden.     

Electron diffraction and electron microscopy studies on the crystalline component of enamel of theOdontaspis (selachii)

Résumé L'auteur constate que dans la dent du Requin du genreOdontaspis l'ultrastucture de la substance qui recouvre la dentine est morphologiquement très semblable à celle de l'émail de la dent humaine. Par diffraction électronique le composant cristallin de l'émail du Requin a été déterminé comme étant del'apatite. Ces résultats montrent que le revêtement externe de la dent d'Odontaspis peut être considéré comme un véritable émail.     

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic transmission is strongly implicated in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol dependence and catamenial epilepsy. Determining how neurosteroids interact with the GABA(A) receptor is a prerequisite for understanding their physiological and pathophysiological roles in the brain. Here we identify two discrete binding sites in the receptor's transmembrane domains that mediate the potentiating and direct activation effects of neurosteroids. They potentiate GABA responses from a cavity formed by the alpha-subunit transmembrane domains, whereas direct receptor activation is initiated by interfacial residues between alpha and beta subunits and is enhanced by steroid binding to the potentiation site. Thus, significant receptor activation by neurosteroids relies on occupancy of both the activation and potentiation sites. These sites are highly conserved throughout the GABA(A )receptor family, and their identification provides a unique opportunity for the development of new therapeutic, neurosteroid-based ligands and transgenic disease models of neurosteroid dysfunction.     

电磁环境数据场多频段绘制算法

针对现有电磁环境绘制研究中未考虑频段信息的情况,提出了一种多频段电磁环境绘制算法。基于光线投射算法实现,对传递函数进行了多频段设计,各频段颜色可以交互设置,同时定义了频段颜色增强因子,能够提高不同频段的颜色对比效果。最后,在统一计算设备架构下并行实现本算法,完成了实时交互的多频段电磁环境绘制。实验证明该算法能够方便、有效的展示电磁环境的频段信息,同时用户可以交互控制绘制及频段对比结果,便于观察和理解电磁环境。     

异构计算的一种可移植编程模型及实现

介绍了异构计算的一种编程模型．该模型处理的对象是任意非一致的求解任务映射到任意非一致的系统结构上．文中分别给出了任务图的分簇算法,系统图的分簇算法和映射算法及实例．利用该模型可设计出可移植的并行程序,然后调度到可动态配置的异构计算机组织上运行