Lawson-Mislove问题的一个必要条件

借助于Dcpo上的Scott拓扑,引进Scott吸收Dcpo的概念,并证明了函数空间上Scott拓扑与Isbell拓扑一致的必要条件是该函数空间的值域Dcpo是Scott吸收的.结果表明,Scott吸收性是Lawson-Mislove问题的一个必要性刻画.     

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

A combined genome-wide association and linkage study was used to identify loci causing variation in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10(-8)) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The association replicated in p.Phe508del homozygotes (P = 0.006) from a separate family based study (n = 557), with P = 1.49 × 10(-9) for the three-study joint meta-analysis. Linkage analysis of 486 sibling pairs from the family based study identified a significant quantitative trait locus on chromosome 20q13.2 (log(10) odds = 5.03). Our findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

短波跳频FH/QDPSK系统信道自适应监测的研究(Ⅱ)

基于短波跳频FH/QDPSK系统的FFT解调,利用FFT解调的结果,提出了在瑞利衰落信道中对信道的BER进行实时自适应监测方法,该方法利用伪错监测及其非线性外推较好地解决了在较短的监测时间内获得较为精确的监测结果。模拟结果表明,采用伪错的非线性外推算法,其估值的最大绝对误差不超过0.28,最大相对误差不超过12.1%。     

The Moment of China's Internet Companies Management Method

文章介绍了我国互联网企业的资本结构后,从市场、技术、人力资源3个方面分析了我国互联网企业的管理之道,最后讨论了互联网企业文化建设的不足和原因.以及如何提高策略.     

Identification of susceptibility genes loci associated with type 2 diabetes

In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Han Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction (PCR-LDR). In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJ1...     

基于Pro/E的车用CNG气瓶装卸机械设计

针对车用CNG气瓶定检时人工装卸气瓶效率低、安全性差等问题,提出设计一种CNG气瓶装卸机械.该装置包括升降小车和机械抓手两部分,可实现对气瓶的抓取、旋转、升降、进退等动作.基于Pro/Engineer的三维建模功能,建立该机械装置、气瓶及车厢的3D模型,进行模拟装卸的结构干涉分析.结果表明该机械结构简单、操作方便,具有...     

微合金非调质40Mn2V钢管的变形抗力研究

采用Gleeble-1500 热模拟实验机对微合金非调质40Mn2V钢管的变形抗力进行了研究.结果表明,变形温度越高,变形速率越低,钢管变形抗力越小.变形抗力对数值lnσ随着温度升高和变形速率对数值lnε·的增大,分别呈线性减小和线性增大,且变形抗力与变形程度呈非线性关系.采用Matlab软件拟合出了微合金非调质40Mn2V钢管的变形抗力公式,其拟合度R为0.966 3.     

析当前我国大学生失业的特点

大学生失业从历史和世界的角度来考察,是一种比较普遍的社会现象。1999年高校扩招之后,我国开始出现了比较突出的大学生失业现象,并引起了人们的高度关注。当前我国大学生的失业现象具有必然性和合理性、主动性和被动性、相对性、差异性等特点,分析这些特点有助于我们全面地辩证地认识大学生失业现象。     

Medical entity and attributes extraction system based on relation annotation

The abundant entities and entity-attribute relations in medical websites are important data resources for medical research. However, the medical websites are usually characterized of storing entity and attribute values in different pages. To extract those data records efficiently, we propose an automatic extraction system which is related to entity and attribute relations (attributes and values) of separate storage. Our system includes following modules: (1) rich-information interactive annotation page rendering; (2) separate storage attribute relations annotating; (3) annotated relations for pattern generating and data records extracting. This paper presents the relations about the attributes which are stored in many pages by effective annotation, then generates rules for data records extraction. The experiments show that the system can not only complete attribute relations of separate storage extraction, but also be compatible with regular relation extraction, while maintaining high accuracy.