续断清除DPPH·自由基的活性

续断(Dipsacusasper Wall.)经95％乙醇冷浸提取,AB-8大孔吸附树脂柱分离,水-乙醇梯度洗脱,得到几个组份.利用紫外分光光度计检测样品对DPPH·自由基的清除活性,结果表明粗提物以及65％、50％、35％的乙醇洗脱液都具有显著的自由基清除作用,其中65％洗脱液的活性最强.     

用于波分复用的全光纤通信技术

给出了一种用于波分复用的全光纤通信系统，对作为该系统重要组成的光纤激光器、掺铒光纤放大器（ＥＤＦＡ）、光纤Ｂｒａｇｇ光栅（ＦＢＧ）滤波器及光检测器等新型器件进行了评述，并论述了全光纤波分复用通信的可行性及其优势。     

自供式伺服变量泵节能液压系统的研究

在一套大型结构加载系统的节能改造中，采用一种新型的无须外加辅助油源的自供式伺服变量泵节能控制系统，并针对容积式控制方式中存在的问题，采用非线性变增益补偿法改善系统动态性能．实践表明，该系统具有良好的降低能耗、减少温升的作用；动态补偿方法效果显著     

The parameter determination in the design of 3-D spherically symmetric FIR filters via the McClellan transformation

In the design of 3-D spherically symmetric FIR filters via the McClellan transformation, two methods are proposed to determine the transformation parameters. The first is to improve the original 3-D algorithm by exploiting the 2-D effective methods in 3-D. This method can change the constrained optimization algorithm into the unconstrained one and makes the design easier to realize. The second method is to solve the coupled equations under constrained conditions and a set of ideal parameters can be gotten. The design example shows that the two methods are all efficient and easier than the original algorithm. Supported by the National Natural Science Foundation of China Jin Xiaoying: born in 1975, Graduate student     

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.     

基于GraphSage节点度重要性聚合的网络节点分类研究

传统的图嵌入算法及图神经网络模型在对网络节点分类时仅使用了节点本身的属性信息或者特征信息,很少使用节点在网络中的结构信息。如何在图神经网络聚合时引入节点网络结构信息来提升分类准确性也是一个值得深入研究的问题。因此,在GraphSage模型的基础上,根据网络中节点度及节点重要性设计了新的聚合函数并提出了GraphSage-Degree模型。首先,模型根据节点度获得节点在邻域中的重要性,然后再以重要性为依据来聚合节点的特征,使得网络中重要的节点能够尽可能的聚合更多的特征信息,并且在GraphSage-Degree中设置了一个与节点度有关的超参数D,能够通过调节该参数D使得在不同的数据集上达到最佳分类状态。在Cora、Citeseer和Pubmed 3个公开数据集上进行了测试,GraphSage-Degree与其他方法相比,macro-F1的平均提升值分别为8.72%、10.37%和8.29%,在Pubmed上有最大提升值38.84%;micro-F1的平均提升值分别为8.97%、11.16%和6.9%,在Pubmed上有最大提升值38.39%。     

疏松砂岩油藏封隔颗粒防砂控水技术矿场实践

南海东部的F油田为疏松砂岩稠油油田,针对投产后出现的储层出砂堵塞筛管,油井产量递减快、见水后含水上升快等难题,在充分调研常规防砂控水技术优缺点的基础上,提出了一种由亲油疏水材料构成的封隔颗粒防砂控水技术。利用实验、油藏工程、数值模拟等方法评价了封隔颗粒的防砂控水效果。结果表明：封隔颗粒防砂控水技术具有无需找水、全井段控水、防砂、绿色环保等多种优势,配合自适应流量控水阀(autonomous inflow control device, AICD),防砂控水效果进一步提升;F油田部分单井矿场采用封隔颗粒防砂控水后,有明显的无水采油期,在相同采出程度的情况条件下,含水上升率明显更低,防砂控水增油效果显著。该技术为类似疏松砂岩油田的防砂控水开发提供了借鉴,推广前景良好。     

融合知识图谱的多通道中医辨证模型

中医辨证是中医临床立法、处方、用药的基础和前提。中医电子病历缺乏高质量语料,模型训练容易欠拟合,且四诊信息的症状表达形式存在较大差异,限制了网络模型对复杂症状的识别能力。针对上述问题,通过对四诊信息多通道的分开处理,以及人工构建的小规模知识图谱对模型训练进行知识的增强,提出了融合知识图谱的多通道中医辨证模型。实验结果表明,基于中医电子病历数据集,提出的模型在P@1指标、P@3指标、P@5指标上相比基线模型分别提高3.51%、3.38%、3.32%,相比其他网络结构模型也有不同程度的提高,验证了所提模型对中医辨证具有显著效果。     

多岩性储集层暂堵压裂缝高扩展特征试验研究

针对多岩性组合储集层的裂缝高度扩展问题,通过制备不同岩性的人工试样,并开展了室内压裂物理模拟试验,同时加入暂堵剂,分析不同岩性差异、射孔位置及排量下的水力压裂缝高扩展特征,创新了试样压后三维裂缝重构方法。结果表明：不同岩性组合试样下的主要缝高截止机制由岩石力学性质所决定,高杨氏模量岩层会阻挡缝高穿层。当层间力学性质差异较小时,裂缝发生转向扩展突破,缝高发生穿层;当层间力学性质差异较大时,裂缝扩展限制于同一岩层,缝高难以突破岩层界面。低排量下,缝高截止于应力区分界面,暂堵压裂后,裂高继续延伸突破高应力区;高排量下,裂缝沿最小主应力横向扩展,加入暂堵剂发生,裂缝转向形成新的裂缝。当射孔位置居上时,试样缝高倾向于向上扩展,暂堵压裂后形成新的起裂点;射孔位置居下,缝高扩展贯穿整个试样,暂堵压裂后形成相平行的新裂缝。研究结果为多岩性组合储集层现场压裂方案设计提供了室内试验指导。     

Benthic foraminiferal δ~(13)C minimum events in the southeastern Okhotsk Sea over the last 180 ka

A total of six d13C minimum events,i.e.,VI,V,IV,III,II,and I,were observed via a stable carbon and oxygen isotope analysis of infaunal benthic foraminifera Uvigerina spp.in gravity core OS03-1 in the southeastern Okhotsk Sea over the last 180 ka.These events occurred at112–109,102–90,85–76,57–54,44–40,and 17–10 ka BP.The largest negative excursions reached 2.5%in event V and were greater than 1%in the other events.We proposed that all d13C minimum events were caused by the increase in sea surface water productivity,the weakened formation of Okhotsk Sea intermediate water,and the enhancement of the oxygen minimum zone.The negative excursions were unaffected by methane hydrate destabilization and subsequent methane release based on the results obtained by using archaeal lipid markers.