Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53+/- mice, but not those from p53-/- mice, show frequent loss of heterozygosity and a 10% mutation rate of the Fbxw7 gene. Fbxw7+/- mice have greater susceptibility to radiation-induced tumorigenesis, but most tumours retain and express the wild-type allele, indicating that Fbxw7 is a haploinsufficient tumour suppressor gene. Loss of Fbxw7 alters the spectrum of tumours that develop in p53 deficient mice to include a range of tumours in epithelial tissues such as the lung, liver and ovary. Mouse embryo fibroblasts from Fbxw7-deficient mice, or wild-type mouse cells expressing Fbxw7 small interfering RNA, have higher levels of Aurora-A kinase, c-Jun and Notch4, but not of cyclin E. We propose that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers.     

黄骅盆地孔西构造带的构造演化特征

通过平衡剖面技术复原古构造演化 ,并结合区域构造分析 ,可将孔西构造带的发育过程大致分为三个构造变形阶段 :晚三叠世末期为挤压褶皱变形期 ;晚三叠世沉积后至侏罗系沉积前为逆冲构造变形期 ;早—中侏罗世为逆冲构造“轻度”渐进变形期。晚侏罗世以后 ,区域构造作用发生反转。随着晚侏罗—早白垩世、早第三纪裂陷盆地的发育 ,孔西构造带作为潜山构造被掩埋。裂陷盆地时期的伸展构造对孔西构造带前第三系的逆冲构造基本上没有大的改造     

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Wnt glycoproteins have been implicated in diverse processes during embryonic patterning in metazoa. They signal through frizzled-type seven-transmembrane-domain receptors to stabilize beta-catenin. Wnt signalling is antagonized by the extracellular Wnt inhibitor dickkopf1 (dkk1), which is a member of a multigene family. dkk1 was initially identified as a head inducer in Xenopus embryos but the mechanism by which it blocks Wnt signalling is unknown. LDL-receptor-related protein 6 (LRP6) is required during Wnt/beta-catenin signalling in Drosophila, Xenopus and mouse, possibly acting as a co-receptor for Wnt. Here we show that LRP6 (ref. 7) is a specific, high-affinity receptor for Dkk1 and Dkk2. Dkk1 blocks LRP6-mediated Wnt/beta-catenin signalling by interacting with domains that are distinct from those required for Wnt/Frizzled interaction. dkk1 and LRP6 interact antagonistically during embryonic head induction in Xenopus where LRP6 promotes the posteriorizing role of Wnt/beta-catenin signalling. Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists.     

Non-Fermi-liquid behaviour in La4Ru6O19

Understanding the complexities of electronic and magnetic ground states in solids is one of the main goals of solid-state physics. Transition-metal oxides have proved to be particularly fruitful in this regard, especially for those materials with the perovskite structure, where the special characteristics of transition-metal-oxygen orbital hybridization determine their properties. Ruthenates have recently emerged as an important family of perovskites because of the unexpected evolution from high-temperature ferromagnetism in SrRuO3 to low-temperature superconductivity in Sr2RuO4 (refs 1, 2). Here we show that a ruthenate in a different structural family, La4Ru6O19, displays a number of highly unusual properties, most notably non-Fermi-liquid behaviour. The properties of La4Ru6O19 have no analogy among the thousands of previously characterized transition-metal oxides. Instead, they resemble those of CeCu6-xAux-a widely studied f-electron-based heavy fermion intermetallic compound that is often considered as providing the best example of non-Fermi-liquid behaviour. In the ruthenate, non-Fermi-liquid behaviour appears to arise from just the right balance between the interactions of localized electronic states derived from Ru-Ru bonding and delocalized states derived from Ru-O hybridization.     

电磁场数值分析的无单元Galerkin方法

阐述了移动最小二乘无单元Galerkin方法的基本原理及实现过程,给出了权函数的选取原则,和基于Lagrange乘子法的边界条件处理方法,结合算例说明了该方法用于电磁场分析的有效性和计算特点,并着重研究了影响半径对计算结果的影响,计算结果表明,对于非均匀媒质,影响半径应在一个与高斯积分点有关的范围内取值,以避免媒质作用的“扩散”而降低计算精度。     

Electrochemical hydrogen storage of aligned multiwalled carbon nanotubes

Hydrogen storage of aligned multi-walled carbon nanotubes (a-MWNTs),non-aligned MWNTs(n-MWNTs) and graphite electrodes are studied by the electro-chemical measurements .The electrodes are prepared by mixing carbon nanotubes (CNTs) copper powder and ptfe binder in a weight ratio of 1:5:3 and compressing the mixture into porous nickel collector,The results show that the electrochemical hydrogen storage capacity of the a-MWNT electrode is up to 1625 mAh/g corresponding to a high hydrogen storage of 5.7 wt% ,which is 10 times that of graphite electrode and is 13 times that of n-MWNT electrode, suggesting that a-MWNTs are promising materials for electrochemical hydrogen storage.     

QTL mapping of the root traits and their correlation analysis with drought resistance using DH lines from paddy and upland rice cross

A Double Haploid (DH) population, 116 plants, derived from the cross between Japonica upland rice IRAT109 and paddy rice Yuefu, planted in PVC pipe under upland ecosystem in 2001 and 2002, was used in this study. Seven root traits, including basal root thickness (BRT), total root number (RN), maximum root length (MRL), root fresh weight (RFW), root dry weight (RDW), ratio of root fresh weight to shoot fresh weight (RFW/SFW) and ratio of root dry weight to shoot dry weight (RDW/SDW), were studied. Using index of drought resistance (IDR), the ratio of yield under upland ecosystem to yield under lowland ecosystem of DH lines, as the criteria of drought resistance, and correla-tion analysis between root traits and IDR, showed that BRT, MRL and RN were significantly correlated with IDR. High IDR lines had thicker BRT, longer MRL and less RN than low IDR lines. A molecular linkage map with 94 RFLP markers and 71 SSR markers covering 1535.1 cM was pro-duced. QTLs and G譋 interactions for BRT, RN, MRL, RFW, RDW, RFW/SFW and RDW/SDW were obtained based on the constructed molecular linkage map and soft-ware QTLmapper version 1.0. A total of 18 additive QTLs and 18 pairs of epistatic QTLs associated with root traits were detected. There were nine additive QTLs and two pairs of epistatic QTLs performed significant interactions with environment. Some QTLs with high general contribution and no G譋 interaction were obtained. Two pairs of epistatic QTLs mrl3 and mrl8, brt3 and brt11a controlling MRL and BRT had high general contributions of 21.51% and 13.03% respectively. An additive QTL and a pair of epistatic QTLs controlling RFW and RDW had high general contributions of 13.50% and 25.64% respectively. Marker assisted selec-tion (MAS) for rice drought resistance based on QTL with high general contribution, low G譋 interaction and tightly linkage with IDR were also discussed.     

振动成型半刚性抗裂水泥稳定碎石基层施工质量控制

从施工前准备、材料拌和、摊铺、碾压及养生等几方面对振动成型半刚性抗裂水泥稳定碎石基层质量控制予以论述,提出施工时应注意的问题及质量控制方法。     

一种新的基于混合策略的动态组密钥管理方案

针对大型动态组通信,提出一种基于Iolus LKH SKDC混合策略的组密钥管理方案。该方案中全局组控制器通过密钥树来管理各个子组控制器,每个子组内采用改进的LKH SKDC方案管理子组成员;子组管理器根据成员ID值,利用单向散列函数计算成员所在路径上各节点密钥值。该方案具有分组管理和集中管理的优点以及良好的可伸缩性,它使LKH方案中的单点失效问题限制在子组范围内,不会对全局产生影响。理论分析和数值结果表明,该方案中子组管理器的密钥存储和动态更新开销大大减少,且用户在加入和退出子组时不会随机产生更新密钥,具有较好的综合性能。