儿童过敏性紫癜研究进展

从流行病学、病因和发病机制、临床表现、辅助检查、诊断标准、治疗方法、预后及随访等方面对儿童过敏性紫癜（HSP)的研究进行了综述.已有的研究充分表明，HSP病因及发病机制尚不明确，免疫及遗传的作用机制还需进一步研究.HSP在临床上缺乏特异性的检查手段，主要依靠患儿症状及体征来诊断；当患儿出现罕见或不常见的临床表现时，组织病理学分析就显得尤为重要.目前国内外尚无统一性及特异性的治疗方案，病情轻者多以对症治疗为主，病情严重者多采用激素进行个体化治疗，但相关的治疗方案还需大样本、多中心临床试验研究以及循证医学验证.HSP短期预后较好，长期预后主要与肾脏受累相关，而减少肾脏受累的关键在于早发现，早诊断，早治疗.     

近代的吴越文化

从鸦片战争到五四时期 ,是中国文化的大转型时期 ,长江下游则是文化转型的先行地区与枢纽地区。吴越文化柔、细、雅的区域个性 ,以及从汉代以来长期形成的政治色彩较淡的传统特点 ,使它在物质文化与精神文化的转型过程中表现突出 ,居全国最前列 ,而在戊戌变法、辛亥革命时期没有出现先知先觉的全国性领袖人物 ,到民国时期 ,这种情况才开始有所改变。     

半线性热方程的一个反问题

讨论了无界区域上半线性热方程确定未知数偶（ｕ，ｐ）的反问题。设计了一种独特的迭代方法，给出了该问题整体解的存在惟一性和稳定性。     

Mixed monotone decomposition of dynamical systems with application

The notions of mixed monotone decomposition of dynamical systems are introduced. The fundamental idea is to make an elaborate use of the natural growth and decay mechanism inherent in the structure of a dynamical systems to decompose its dynamics into increase and decrease parts, and thereby to constitute an augmented dynamical system as the secalled “two-sided comparison system” of the original one. The corresponding two-sided comparison theorems show that the solution of the comparison system gives lower and upper bounds of that of the original system. Therefore, the properties of a dynamical system can be obtained through the study of its two-sided comparison system. Compared with the conventional comparison method in literature, the mixed monotone decomposition method developed herein takes in a natural way structural properties of dynamical systems into account instead of requiring strict conditions of (quasi-)monotonicity on them, and could yields refined, usually nonsymmetrical, state estimates, and thus is more suitable for systems with nonsymmetrical state constraints. As an application of the method, a sufficient condition is established for the global asymptotic stability of the trivial solution of a class of continuous-time systems with nonsymmetrical state saturation. The condition is given in terms of coefficients and state saturation levels of such systems, and contains as a special case a recent result on systems with symmetric state saturation in literature.     

现场总线技术及其应用研究

课题研究了现场总线的概况、分类及主从站的种类,其中PROFIBUS总线应用较多,针对PROFIBUS总线技术研究了主站的结构形式,从站接口分类。PROFIBUS总线通讯协议,以及PROFIBUS总线与自动化系统的连接．     

湖南省学术类科技期刊第三次等级评定情况的分析

对河南省学术类科技期刊第三次等级评定情况进行了分析，首先论述了湖南省学术类科技期刊具有基础好、编辑力量强、学术氛围浓、学会活动经常等优势；然后指出存在经济效益差、论文质量不高、执行国家标准不严等问题；最后对评估指评了简要的分析。     

具有4个传输零点的源-负载耦合滤波器

为了得到高选择性、小尺寸、低损耗和低成本的射频带通滤波器,提出了一种具有4个传输零点的源–负载耦合滤波器的设计方法.该滤波器采用二分之一波长T形多模谐振器,以减小滤波器尺寸和方便带宽设计.同时,根据信号的多路径传输产生零点原理,在滤波器的输入和输出端口之间加入可控耦合元件,为信号的传输提供多条路径,使得该滤波器可产生4个独立于带宽和中心频率的可控零点.文中最后设计和制作了一个带内最小测量插损为1.4dB、相对带宽为10%、具有4个传输零点的小型微带滤波器,并对其进行了测试,测试结果与仿真结果吻合良好,说明这种设计方法是有效的.     

居住区道路夜间光环境安全心理影响因素

居住区作为居民最熟悉的户外环境,其步行道路夜间光环境的适人化设计显得尤为重要.通过构建虚拟模型还原居住区内人车混行道路的照明环境,采用眼动仪记录虚拟场景中受试者的眼动特征,并获取其对测试环境的心理感受评分,研究了居住区夜间光环境中色温、灯具安装高度与安装间距等因素对行人生理与心理的影响特征.结果表明:光源色温值在380...     

The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells

In both cardiomyocytes and HeLa cells, hypoxia (1% O₂) quickly leads to microtubule disruption, but little is known about how microtubule dynamics change during the early stages of hypoxia. We demonstrate that microtubule associated protein 4 (MAP4) phosphorylation increases while oncoprotein 18/stathmin (Op18) phosphorylation decreases after hypoxia, but their protein levels do not change. p38/MAPK activity increases quickly after hypoxia concomitant with MAP4 phosphorylation, and the activated p38/MAPK signaling leads to MAP4 phosphorylation and to Op18 dephosphorylation, both of which induce microtubule disruption. We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580, a p38/MAPK inhibitor, increases and MKK6(Glu) overexpression decreases hypoxic cell viability. Our results demonstrate that hypoxia induces microtubule depolymerization and decreased cell viability via the activation of the p38/MAPK signaling pathway and changes the phosphorylation levels of its downstream effectors, MAP4 and Op18.     

Quantitative reactivity profiling predicts functional cysteines in proteomes

Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we describe a proteomics method to profile quantitatively the intrinsic reactivity of cysteine residues en masse directly in native biological systems. Hyper-reactivity was a rare feature among cysteines and it was found to specify a wide range of activities, including nucleophilic and reductive catalysis and sites of oxidative modification. Hyper-reactive cysteines were identified in several proteins of uncharacterized function, including a residue conserved across eukaryotic phylogeny that we show is required for yeast viability and is involved in iron-sulphur protein biogenesis. We also demonstrate that quantitative reactivity profiling can form the basis for screening and functional assignment of cysteines in computationally designed proteins, where it discriminated catalytically active from inactive cysteine hydrolase designs.