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71.
Genome-wide association studies of 14 agronomic traits in rice landraces 总被引:20,自引:0,他引:20
Huang X Wei X Sang T Zhao Q Feng Q Zhao Y Li C Zhu C Lu T Zhang Z Li M Fan D Guo Y Wang A Wang L Deng L Li W Lu Y Weng Q Liu K Huang T Zhou T Jing Y Li W Lin Z Buckler ES Qian Q Zhang QF Li J Han B 《Nature genetics》2010,42(11):961-967
Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ~ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ~ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice. 相似文献
72.
Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm 总被引:9,自引:0,他引:9
Huang X Zhao Y Wei X Li C Wang A Zhao Q Li W Guo Y Deng L Zhu C Fan D Lu Y Weng Q Liu K Zhou T Jing Y Si L Dong G Huang T Lu T Feng Q Qian Q Li J Han B 《Nature genetics》2012,44(1):32-39
A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice. 相似文献
73.
The genome of the extremophile crucifer Thellungiella parvula 总被引:1,自引:0,他引:1
Dassanayake M Oh DH Haas JS Hernandez A Hong H Ali S Yun DJ Bressan RA Zhu JK Bohnert HJ Cheeseman JM 《Nature genetics》2011,43(9):913-918
Thellungiella parvula is related to Arabidopsis thaliana and is endemic to saline, resource-poor habitats, making it a model for the evolution of plant adaptation to extreme environments. Here we present the draft genome for this extremophile species. Exclusively by next generation sequencing, we obtained the de novo assembled genome in 1,496 gap-free contigs, closely approximating the estimated genome size of 140 Mb. We anchored these contigs to seven pseudo chromosomes without the use of maps. We show that short reads can be assembled to a near-complete chromosome level for a eukaryotic species lacking prior genetic information. The sequence identifies a number of tandem duplications that, by the nature of the duplicated genes, suggest a possible basis for T. parvula's extremophile lifestyle. Our results provide essential background for developing genomically influenced testable hypotheses for the evolution of environmental stress tolerance. 相似文献
74.
Previously proposed differential modulation schemes for time-varying channels may not achieve the full transmit diversity and the maximum Doppler diversity simultaneously. Based on an existing basis expansion model, a new differential space-time code, which wisely combines interleaver/de-interleaver with traditonal space-time transmitting technique to overcome such limitation, .is presented. Two noncoherent differential decoders, named decision-feedback differential detector (DF-DD) and Viterbi-algorithmbased multiple-symbol-detection differential detector ( MSD-DD), are also derived. We show that our design may recover data symbols with full antenna diversity and the maximum Doppler diversity at high signal-to-noise ratio. System performance is evaluated with simulations. 相似文献
75.
Journal of Systems Science and Complexity - This article studies the estimation and statistical inference problems of semi-functional partially linear regression models when the covariates in the... 相似文献
76.
本文对微小浮动间隙的磁头浮动块的动态浮动性能进行了仿真计算。在考虑头盘碰撞的基础上,分析了磁头浮动块对冲击的响应。分析结果表明:在微小浮动间隙的头盘系统中,盘片表面粗糙度和外界干扰冲击对浮动块的浮动性能影响较大。新的动态浮动理论中,必须包含头盘磁撞的研究。 相似文献
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80.
Mg、Cd掺杂AlN电子结构的第一性原理计算 总被引:2,自引:0,他引:2
基于密度泛函理论(DFT)框架下的第一性原理的平面波超软赝势方法(USPP),对Mg,Cd掺杂AlN的32原子超原胞体系进行了几何结构优化,从理论上给出了掺杂和 掺杂体系的晶体结构参数.计算了掺杂AlN晶体的结合能,电子态密度,差分电荷密度,并对计算结果进行了细致的分析.计算结果表明,相对于Cd,Mg在AlN晶体中可以提供更多的空穴,有利于形成更好的p型电导. 相似文献