对摩擦力作功与摩擦生热的量度的认识

本文通过对摩擦力作功与不擦生热的讨论，给出摩擦生热的量度方法．     

改良低温麻醉阻断循环对肺超微结构影响的实验研究

本组用本地健康杂种犬10只,以改良低温麻醉体表降温方法将食道温度降至24～26℃时,然后阻断循环无体外循环下进行心内直视手术。术中分别在阻断前:阻断后及复苏后取肺组织进行光镜、电镜检查。实验结果表明,阻断时间在60分钟内,心脏跳停80分钟内无明显超微结构变化。而阻断时间65～85分钟,心脏跳停90～115分钟,肺组织的某些超微结构变化是可以复原的,这就为不用体外循环的肺脏手术安全时限提供了初步的理论依据。     

一种含稀土锰钢的热处理和低温韧性研究

本文研究了加稀土5％Mn钢的热处理、组织和机械性能,探索其部分代替9Ni钢使用于-196℃的可能性,并以同样成分的无稀土钢作为对比,研究稀土在该钢中的作用。     

中药材中孳生粉螨的初步调查

本文采用清水漂浮法和塔氏电热集螨器分离法,共分离中药材样本124种,1240份,从中分离出粉螨45种,隶属7科23属.得出结论:中药材粉螨的污染严重,应加强对中药螨类的防治,以保护中药材及预防人体螨病.     

Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells.

Low concentrations of inositol 1,4,5-trisphosphate (InsP3) evoke a very rapid mobilization of intracellular Ca2+ stores in many cell types, which can be followed by a further, much slower efflux. Two explanations have been suggested for this biphasic release. The first proposes that the Ca2+ stores vary in their sensitivity to InsP3, and each store releases either its entire contents or nothing (all-or-none release); the second proposes instead that the stores are uniformly sensitive to the effects of InsP3, but that they can release only a fraction of their Ca2+ before their sensitivity is somehow attenuated (steady-state release). Experiments using purified InsP3 receptor molecules reconstituted into lipid vesicles have shown heterogeneity of the receptors in their response to InsP3 under conditions in which the total Ca2+ level at both sides of the receptor is held constant. We now report that in permeabilized A7r5 smooth-muscle cells incubated in Ca(2+)-free medium, the amount of 45Ca2+ remaining in the stores after the rapid transient phase of release is independent of their initial Ca2+ levels, indicating that partially depleted stores are less sensitive to InsP3. Moreover, if the stores are reloaded with 40Ca2+ after the first stimulus, reapplication of the same low concentration of InsP3 will release further 45Ca2+. This recovery of InsP3 sensitivity is almost complete. Under these conditions, Ca2+ release must thus occur by a steady-state mechanism, in which the decreasing Ca2+ content of the stores slows down further release.     

多目标多阶段决策问题最优化方法及应用

本文提出了可行状态点,可行边和可行策略等概念,建立了一种新的解决多目标多阶段决策问题的方法,介绍了这一方法的应用实例:     

Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum.

Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the trans-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle, but retrograde transport of endocytosed material beyond the trans-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the trans-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol.