破除“西部意识”:西部高等教育全面振兴的思路与策略

全面振兴西部高等教育是推进新时代西部大开发的重要方面,是《中国教育现代化2035》重点部署的十大战略任务的重要内容。西部高等教育振兴已取得很大成绩,但全面振兴仍在路上,其面临的真正约束是“西部意识”的思想约束。因此,西部高等教育的全面振兴,需要破除“西部意识”,突破思想约束。要坚持追求卓越,切实提高西部高等教育定位站位,确立西部高等教育志存高远、对标一流的发展意识,激发不懈奋斗、追求卓越的精神动力。要坚持问题导向,深化改革,通过建构信息化时代西部高等教育发展新生态、加快推进西部高等教育思想观念更新、强化西部高等教育振兴的制度供给、增强西部高等教育自主发展能力等举措,全面增强自我“造血”功能,推动西部高等教育全面振兴,加快实现教育现代化。     

Underdetermined DOA estimation and blind separation of non-disjoint sources in time-frequency domain based on sparse representation method

This paper deals with the blind separation of nonstation-ary sources and direction-of-arrival （DOA） estimation in the under-determined case, when there are more sources than sensors. We assume the sources to be time-frequency （TF） disjoint to a certain extent. In particular, the number of sources presented at any TF neighborhood is strictly less than that of sensors. We can identify the real number of active sources and achieve separation in any TF neighborhood by the sparse representation method. Compared with the subspace-based algorithm under the same sparseness assumption, which suffers from the extra noise effect since it can-not estimate the true number of active sources, the proposed algorithm can estimate the number of active sources and their cor-responding TF values in any TF neighborhood simultaneously. An-other contribution of this paper is a new estimation procedure for the DOA of sources in the underdetermined case, which combines the TF sparseness of sources and the clustering technique. Sim-ulation results demonstrate the validity and high performance of the proposed algorithm in both blind source separation （BSS） and DOA estimation.     

建筑结构设计软件动力时程分析功能比较

利用SATWE、MIDAS/Building和ETABS软件分别对结构地震作用进行计算以获得其在地震作用下的反应,来判断结构整体的安全性和可靠性.对3种软件在前处理、分析过程中、后处理3方面进行对比,得出在前处理中MIDAS/Building在建模、选波和调波方面具有一定的优势,并且在后处理方面提供了丰富的后处理功能,便于操作人员快速查询结果.     

GLP-1R agonists therapy for type 2 diabetes

Glucagon-like peptide-1 receptor （GLP-1R） agonists are widely used for treating type 2 diabetes mellitus （T2DM） be- cause of their glucose-lowering and weight-losing effects, and low risk of hypoglycemia. Hence, there is considerable interest in understanding the mechanism underlying the beneficial effects of GLP-I and developing stable and effective GLP-1R agonists. Here, we summarize the presently known mechanism of GLP-I actions, which are mainly through regulating cAMP-PKA signaling pathway; the latest developments in novel clinical GLP-1R agonists are also introduced, which are characterized with multiple properties, such as extended half-life, reduced side-effects, lower production costs and more convenient drug dosing mode. The potential risk of GLP-I-based therapeutics, an often-ignored fact, is also discussed.     

Optimal bundling and pricing decisions for complementary products in a two-layer supply chain

This article explores bundling and pricing decisions for two complementary products in a two-layer supply chain consisting of a multi-product manufacturer and a retailer. We establish four different pricing models under cases of decentralized decision, while considering different portfolio-bundling strategies of the manufacturer and the retailer. A game-theoretical method is used to characterize the corresponding equilibrium outcomes in each scenario. By further analyzing and comparing the maximum profits of all four possible scenarios, optimal bundling and pricing decisions for the manufacturer and the retailer are obtained, respectively. Model extensions and numerical examples are enriched to highlight the factors affecting optimal decision-making. Finally, valuable and interesting managerial insights are summarized. Results show that the upstream manufacturer always profits more when he sells complementary products separately. However, the optimal bundling decision of the downstream retailer is jointly determined by product complementarity (as a major factor) and the difference of product profitability (as a secondary factor). Market power cannot exert an influence on both optimal bundling decisions, but it can partly affect pricing decisions.     

离散加权信源与熵密度偏差的极限性质

利用熵密度偏差，研究了服从几分分布的离散加权信源的极限性质，其主要结果推广了离散信源Shannon－Mcmillan定理。     

Asymptotic behavior of solutions for the one-dimensional drift-diffusion model in the quarter plane

In this paper, we study the classical drift-diffusion model arising from the semiconductor device simulation, which is the simplest macroscopic model describing the dynamics of the electron and the hole. We prove the global existence of strong solutions for the initial boundary value problem in the quarter plane. In particular, we show that in large time, these solutions tend to the nonlinear diffusion wave which is different from the steady state, at an algebraic time-decay rate. As far as we know, this is the first result about the nonlinear diffusion wave phenomena of the solutions for the one-dimensional drift-diffusion model in the quarter plane.     

Multi-dimensional scattering properties diagnosis system of scale aircraft model in an anechoic chamber

Aiming at the concept of ＂diagnosis＂, a simple and effective broadband radar cross section （RCS） measurement system is constructed, and some multi-dimensional scattering properties diagnosis techniques are presented based on the system. Firstly, a stepped-frequency signal is employed to achieve high range resolution, combining with a variety of signal processing tech- niques. Secondly, cross-range resolution is gained with a rotating table, and the high-resolution two-dimensional （2-D） imaging of the scale model is obtained by the microwave imaging theory. Finally, two receiving antennas with a small distance in altitude are used, and the three-dimensional （3-D） height distribution of scattering points on the scale model is extracted from the phase of images. Some typical bodies and a scale aircraft model are diagnosed in an anechoic chamber. The experimental results show that, after scaling with a metal sphere, the accurate one- dimensional （l-D） RCS pattern of the model is obtained, and it has a large dynamic range. When the bandwidth of the transmitting signal is 4 GHz, the resolution of the 2-D image can reach to 0.037 5 m. The 3-D height distribution of scattering points is given by interferometric measurement. This paper provides a feasible way to obtain high-precision scattering properties parameters of the scale aircraft model in a conventional rectangular anechoic chamber.     

由关联理论看赵本山小品的言语幽默

喜剧小品是一种给人带来愉悦的幽默形式.文章以赵本山的小品<不差钱>和<昨天·今天·明天>为例,运用关联理论对其中的言语幽默进行分析,旨在说明关联理论对幽默的产生有很强的解释力,为欣赏和创作小品提供一个语用视角.     

An important functional group,benzo[1,3]dioxole,of alkaloids induces the formation of the human telomeric DNA G-quadruplex

Over the past few decades, numerous molecules have been discovered or designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Some of these molecules have been developed as anticancer agents. To aid the design of anticancer agents, the ability of alkaloids possessing Protoberberine and Benzophenanthridine groups to induce the formation of G-quadruplexes were studied using CD spectroscopy. By careful examination of their structures, we found that a benzo[1,3]dioxole group plays an important role in influencing their inductive properties. The more functional groups the alkaloids have, the stronger their G-quadruplex inductive ability.