A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

锶铁氧体的结构特征及制备方法研究现状

对锶铁氧体的结构、性能特征以及主要制备方法进行了综合评述.锶铁氧体为六角晶系,属于M型铁氧体,其矫顽力主要取决于磁晶各向异性;制备方法主要有陶瓷法、化学共沉淀法、水热法、溶胶-凝胶法、熔盐合成法和自蔓延高温合成法等.水热法和溶胶-凝胶法因具有工艺简单、产品磁性能高等优点,是今后高性能锶铁氧体制备技术的主要研究方向.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

我国光伏设备技术发展现状与趋势研究

光伏产品生产制造在当前是设备制造行业当中的新领域。目前,我国的光伏设备技术发展还处于初级发展阶段,但由于其对于产业的结构调整和产业进步有着巨大的作用,因此得到了大力的推广,并且也为设备制造业提供了极大的保障。本文主要对我国光伏设备技术的发展现状进行了分析,并对其未来发展趋势进行了进一步的讨论,希望为相关人士提供一些有益参考。     

水栖性的棘胸蛙身体大小不随环境水热梯度及净初级生产力梯度而分化

之前的研究发现不同地理种群棘胸蛙(Quasipaa spinosa)的身体大小随着环境生产力以及年最低温的降低而增大,因为更大的身体利于在生产力水平较低的环境中耐受饥饿并利于在寒冷的环境条件下保存热量.然而在种间水平上进行的相关研究发现:由于大部分时间生活在水体这种相对稳定的环境中,水栖性无尾类的身体大小并不受宏观水热波动的影响.为了更好地探究这个问题,我们以棘胸蛙为研究对象,在之前的基础上选择更多的研究地点及更多的环境因子,研究其身体大小的地理分化格局并探究潜在机制.与之前的发现不同,作为一种水栖性无尾类,棘胸蛙的身体大小并不受环境水热梯度以及净初级生产力梯度的影响.导致这种现象的原因可能是水栖性的生境偏好缓和了棘胸蛙受到的来自宏观环境水热波动的影响,所以它们并不通过改变身体大小来适应宏观环境梯度.此外由于棘胸蛙的肉食性,环境初级生产力并不能有效地衡量其食物供给,其身体大小是否受到食物供给量的影响仍有待深入探究.     

头盘微小间隙动态浮动理论研究

本文对微小浮动间隙的磁头浮动块的动态浮动性能进行了仿真计算。在考虑头盘碰撞的基础上,分析了磁头浮动块对冲击的响应。分析结果表明:在微小浮动间隙的头盘系统中,盘片表面粗糙度和外界干扰冲击对浮动块的浮动性能影响较大。新的动态浮动理论中,必须包含头盘磁撞的研究。     

A sparse algorithm for adaptive pruning least square support vector regression machine based on globalrepresentative point ranking

Least square support vector regression(LSSVR)is a method for function approximation,whose solutions are typically non-sparse,which limits its application especially in some occasions of fast prediction.In this paper,a sparse algorithm for adaptive pruning LSSVR algorithm based on global representative point ranking(GRPR-AP-LSSVR)is proposed.At first,the global representative point ranking(GRPR)algorithm is given,and relevant data analysis experiment is implemented which depicts the importance ranking of data points.Furthermore,the pruning strategy of removing two samples in the decremental learning procedure is designed to accelerate the training speed and ensure the sparsity.The removed data points are utilized to test the temporary learning model which ensures the regression accuracy.Finally,the proposed algorithm is verified on artificial datasets and UCI regression datasets,and experimental results indicate that,compared with several benchmark algorithms,the GRPR-AP-LSSVR algorithm has excellent sparsity and prediction speed without impairing the generalization performance.     

协同多点传输中迫零预编码和天线选择技术

MIMO无线传输技术极大地提高了系统的容量,在实际通信系统中,整个网络是一个干扰受限的系统,小区间干扰对MIMO系统传输的影响是显著的,每个相邻小区的基站天线都可以看成一个干扰源．由于基站端数据处理能力的提升和回程容量的增加,多个小区协同多点传输技术引起了人们的广泛关注．目前的大部分工作都是集中于研究系统的容量（吞吐量）,而在实际系统中,每个用户的接收等效信噪比（即公平性）对系统的性能如误帧率等有重要的影响．对于每个用户为单天线的情形,研究了总功率受限和每天线功率受限下采用迫零预编码的系统容量和公平性．对两种功率约束条件下的公平性进行了分析,得到了公平性算法的闭式表达式．当每个用户为多天线的情形,为了降低计算的复杂度,引入了信道范数最大的接收天线选择算法,把每个用户为多天线的情形转化成等效的每个用户单天线情形,推导的每用户为单天线的公平性算法仍然适用．仿真结果显示,采用迫零预编码的多小区协作可以使系统性能显著提升．在相同的迫零预编码下,不同的功率分配策略对系统的容量和公平性有显著的影响．和用户为单天线相比,采用天线选择算法可以提升系统的容量和公平性．考虑了用户公平性时的吞吐量和最大系统吞吐量之间的折中关系,并给出了仿真结果．