基于理性期望的利率期限结构预期理论与期限溢酬

推导了两种检验期限结构预期理论的方法.指出基于这些回归方程来检验预期理论,实际上是对理性期望、期限结构预期理论和期限溢酬不变的联合检验,实证研究中对预期理论的拒绝可能是由于未考虑到期限溢酬的时变性.在此基础上,基于Kalman滤波的期限溢酬估计模型.提出了一个利用即期利率数据.利用上海证券交易所国债交易数据对该模型进行实证研究,分析了该市场期限溢酬的行为特征.     

基于DSP的谐波电流检测

随着电力电子技术的迅猛发展,电力电子装置产生的谐波对公用电网产生的危害,引起了人们越来越多的关注。文章基于瞬时无功功率理论的ip-iq算法,重点研究了采用TMS320F240芯片时电网中的谐波电流进行实时检测的方法,并借助MAT-LAB进行了仿真。仿真结果表明,这种检测和计算方法以及硬件结构可以满足电网中谐波检测实时性、准确性的要求。     

SEA方法及其在$C^3I$系统效能分析中的应用(Ⅲ)——监视模型

针对ＳＥＡ方法的要求,提出了评估$Ｃ^３Ｉ$系统在执行监视任务时的系统效能的三个性能量度（ＭＯＰ）,通过分析$Ｃ^３Ｉ$系统在执行监视任务时的行为过程和环境特点,结合排队理论,建立了评估$Ｃ^３Ｉ$系统监视效能的ＳＥＡ方法模型．利用该模型计算了一个实际$Ｃ^３Ｉ$系统的监视效能,并对结果进行了简要分析．     

红外焦平面阵列非均匀校正算法研究

红外图像的非均匀性已经成为制约红外焦平面阵列成像质量的限制性因素。本文对红外非均匀性的定义和来源进行了深入的探讨,给出了几种非均匀校正算法及其实验结果,最后对各种校正算法的特点进行了归纳总结。     

基于蚁群系统的仿真机器人足球攻防转换策略

为了提高机器人足球的整体攻防能力,在动态攻防转换策略中建立了基于蚁群系统的混合通信机制,既增强了足球机器人的协作能力,又避免了足球机器人陷入冲突或任务死锁状态,增加了攻防转换的灵活性。在该通信机制的基础上采用攻防区域划分的方法,以球的位置为驱动信息,通过信息素来确定变换队形。在FIRA仿真平台中实验表明,基于蚁群混合通信机制的动态攻防转换策略使得仿真足球机器人在比赛过程中表现出更优异的性能,改善了球队的整体攻防能力,可有效应用于机器人足球比赛中。     

风机振动分析与故障诊断

应用振动分析方法、数据采集技术及诊断理论对某乙烯厂Ｅ－ＧＢ１０９风机进行了现场振动测量、信号的采集与分析诊断,找出了风机振动的原因。     

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia

Phosphodiesterases (PDEs) regulate cyclic nucleotide levels. Increased cyclic AMP (cAMP) signaling has been associated with PRKAR1A or GNAS mutations and leads to adrenocortical tumors and Cushing syndrome. We investigated the genetic source of Cushing syndrome in individuals with adrenocortical hyperplasia that was not caused by known defects. We performed genome-wide SNP genotyping, including the adrenocortical tumor DNA. The region with the highest probability to harbor a susceptibility gene by loss of heterozygosity (LOH) and other analyses was 2q31-2q35. We identified mutations disrupting the expression of the PDE11A isoform-4 gene (PDE11A) in three kindreds. Tumor tissues showed 2q31-2q35 LOH, decreased protein expression and high cyclic nucleotide levels and cAMP-responsive element binding protein (CREB) phosphorylation. PDE11A codes for a dual-specificity PDE that is expressed in adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors; its germline inactivation is associated with adrenocortical hyperplasia, suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

SET domain protein lysine methyltransferases: Structure, specificity and catalysis

Site- and state-specific lysine methylation of histones is catalyzed by a family of proteins that contain the evolutionarily conserved SET domain and plays a fundamental role in epigenetic regulation of gene activation and silencing in all eukaryotes. The recently determined three-dimensional structures of the SET domains from chromosomal proteins reveal that the core SET domain structure contains a two-domain architecture, consisting of a conserved anti-parallel β-barrel and a structurally variable insert that surround a unusual knot-like structure that comprises the enzyme active site. These structures of the SET domains, either in the free state or when bound to cofactor S-adenosyl-L-homocysteine and/or histone peptide, mimicking an enzyme/cofactor/substrate complex, further yield the structural insights into the molecular basis of the substrate specificity, methylation multiplicity and the catalytic mechanism of histone lysine methylation. Received 10 June 2006; accepted 22 August 2006