中点软定位簧多工位级进模材料的强韧化处理

本文论述了中点软定位簧多工位级进模国产化的选材和热处理工艺路线,并对模具材料的强韧化处理进行了实验研究。结果表明,以淬火作为予处理,获得非平衡组织,再经淬火、回火处理,可细化奥氏体晶粒和细化炭化物,可提高Crl2MoV钢的强韧性。而真空热处理,可进一步改善材料的韧性使模具材料具有良好的强韧性配合。因此,可使模具具有高的使用寿命。     

中心城市现代远程开放教育教学管理模式的解析与建构

以广州电大的现代远程开放教育教学管理实践为案例,结合现代远程开放教育、中心城市和教学管理对象特点,分析了现代远程教育的内涵特点,构建了“开放辐射式”教学管理模式基本框架。     

三脚架多齿胺Mn(II)、Ni(II)配合物仿酶性能研究

合成了三-(6-甲基-2-吡啶甲基)胺(TLA)的叠氮桥联双核锰(II)、镍(II)配合物,对两种金属配合物模拟甲基单加氧酶催化苯乙烯环氧化反应的性能进行了研究,并讨论了温度、催化剂浓度等反应条件对催化作用的影响,分析了分子结构与催化活性的关系.通过对EPR光谱和UV-v is光谱的研究,得到了高价金属氧酰(M=O)活性中间物的信息,提出了反应机理.应用比色法考察了两种配合物对羟基自由基的清除作用.     

一种改进的合理井控储量与采收率确定方法

合理井控储量是油田开发设计的核心内容,其大小直接影响采收率的高低。以中石油勘探开发研究院经验公式为基础,通过对公式系数的修正,建立了新的采收率和井控储量关系式;同时为增加公式的适用性,提出了以水平井与直井间的产能比来表征替换比确定井控储量的方法。最后利用南海西部8个水驱砂岩油藏标定采收率和井控储量对改进公式进行了检验。结果表明:利用驱油效率代替原公式系数后的新公式实用性更好,能够更好地反应采收率随井控储量的变化;利用水平井与直井间产能比来表征替换比的方法在南海西部油田应用效果较好。     

Site-specific DICER and DROSHA RNA products control the DNA-damage response

Non-coding RNAs (ncRNAs) are involved in an increasingly recognized number of cellular events. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to small double-stranded RNAs involved in RNA interference (RNAi). The DNA-damage response (DDR) is a signalling pathway that originates from a DNA lesion and arrests cell proliferation3. So far, DICER and DROSHA RNA products have not been reported to control DDR activation. Here we show, in human, mouse and zebrafish, that DICER and DROSHA, but not downstream elements of the RNAi pathway, are necessary to activate the DDR upon exogenous DNA damage and oncogene-induced genotoxic stress, as studied by DDR foci formation and by checkpoint assays. DDR foci are sensitive to RNase A treatment, and DICER- and DROSHA-dependent RNA products are required to restore DDR foci in RNase-A-treated cells. Through RNA deep sequencing and the study of DDR activation at a single inducible DNA double-strand break, we demonstrate that DDR foci formation requires site-specific DICER- and DROSHA-dependent small RNAs, named DDRNAs, which act in a MRE11–RAD50–NBS1-complex-dependent manner (MRE11 also known as MRE11A; NBS1 also known as NBN). DDRNAs, either chemically synthesized or in vitro generated by DICER cleavage, are sufficient to restore the DDR in RNase-A-treated cells, also in the absence of other cellular RNAs. Our results describe an unanticipated direct role of a novel class of ncRNAs in the control of DDR activation at sites of DNA damage.     

Study on the FEM design of reinforced earth retaining wall with geogrid

At present, limit equilibrium method is often adopted in the design of reinforced earth retaining wall. Geotechnical engineers at home and abroad have done a lot of work to improve the traditional calculation methods in recent years, while there are lots of defects. This paper first identifies the location of failure surface and safety factor through the finite element program of PLAXIS and then analyses the influencing factors of the stability of reinforced earth retaining wall with geogrid. The authors adopt strength reduction FEM in the design and stability analysis of reinforced earth retaining wall and have achieved some satisfying results. Without any assumptions, the new design method can automatically judge the failure mode of reinforced earth retaining wall; can consider the influence of axial tensile stiffness of the reinforcement stripe on the stability of retaining wall; can identify reasonable distance and length of the reinforcement stripe; can choose suitable parameters of reinforcement stripe, including strength, stiffness and pseudo-friction coefficient which makes the design optimal. It is proved through the calculation examples that this method is more reasonable, reliable and economical in the design of reinforced earth retaining wall.     

Research on technology of automatic welding machine and procedure for pile pipes of offshore jacket platform

Because of the high requirement of quality, vile working environment and great difficulty of automatic welding, MMA is usually adopted for the welding of the platform jacket and the pile pipe all over the world, which is one of the choke points influencing construction with low efficiency and hard working. In this article, an up to date technology for platform pile pipes welding is introduced. Core with FCW-S and combining with the character and requirement of platform construction, the special automatic horizontal welding equipment and process are developed. Further more, the application off shore are introduced too.     

EMD-Tnorm得分规整策略在说话人确认中的应用

从两个方面对确认系统进行了改进,在模型方面,扩展了MixMax模型,对复杂的背景噪声等干扰因素在训练说话人模型的同时也进行了建模,最大程度上消除噪声的影响,对说话人的特征分布进行了更真实的表征;在得分方面,提出了一种改进的得分规整策略,基于EMD距离从所有背景说话人集合中自适应选择最接近的一定数量的模型构成说话人特定的背景集合,从而进行得分归一化。实验结果表明,该方法能够同时针对说话人和测试环境的不同进行补偿,进一步降低了误识率和漏警率,获得了很好的确认性能。     

喀斯特高原山区刺梨种植空间格局变化与地形土壤影响因素——以贵州省盘州市为例

为了研究近年来喀斯特高原山区刺梨种植空间格局变化与地形土壤的影响,以盘州市为例,对影像采用目视解译、地学统计分析及实地调研等方法获取2017年和2019年的刺梨种植空间分布特征,引入RS和GIS技术手段详细研究了2017年和2019年的刺梨种植空间分布格局时空变化特征与地形因子、土壤养分含量之间的相关性.研究结果表明:...     

氧化锌避雷器测试仪校准装置的研制

传统的氧化锌避雷器测试仪校准方法存在难以模拟含有基波阻性电流、容性电流和三次阻性电流的难题。设计了低噪声的电路架构,通过研制参考电压、全电流发生器、功率放大电路和反馈电路,产生标准的正弦波参考电压信号和含有一次阻性电流、三次阻性电流和一次容性电流的全电流信号,通过高精度回测电路确保输出信号的准确度。经过实验验证,该校准装置电压、电流基波准确度小于等于0.1%,三次谐波优于1%,完全满足实验室校准需求,解决了氧化锌避雷器测试仪的校准难题。