心绞痛患者经PCI治疗后不良心脏事件与血清总胆红素水平相关性分析

目的分析心绞痛患者经PCI治疗后不良心脏事件与血清总胆红素水平的相关性.方法选取行PCI的129例心绞痛患者,根据血清TBIL水平将患者分为对照组和观察组,比较两组患者实验室检查指标;比较分析两组患者冠状动脉造影检查结果;比较分析两组患者行PCI的相关指标;比较两组患者发生不良心血管事件(MACE)的情况,并进行Cox比例风险回归分析.结果观察组患者TG,TC水平高于对照组,差异具有统计学意义(P0.05),而其余指标(血糖、Scr、Hb、LDL-C、HDL-C、AST)两组患者比较差异无统计学意义(P0.05);观察组患者冠状动脉病变支数、靶病变部位、慢性闭塞病变及LVEF≤40%与对照组比较差异均无统计学意义(P0.05);观察组患者置入支架长度长于对照组,差异具有统计学意义(P0.05);两组患者经桡动脉途径行PCI者所占比例、置入支架数和置入支架直径与对照组比较,差异无统计学意义(P0.05);术后观察组患者随访期间MACE发生率为24.1%,高于对照组的8.4%,差异具有统计学意义(P0.05);Cox比例风险回归分析结果显示:血清TBIL水平是心绞痛患者PCI后MACE的保护因素,置入支架长度则是危险因素.结论心绞痛患者PCI后血清TBIL水平越低其预后越差;血清TBIL水平是心绞痛患者PCI后MACE的保护因素,置入支架长度则是危险因素.     

向海自然保护区昆虫资源调查

湿地是一种特殊的土地资源和生态环境,具有调节水分循环、维持湿地特有动植物生存等基本生态功能.调查向海国家级自然保护区昆虫资源,共采集昆虫114种,隶属12目63科.在物种组成上,以鳞翅目、鞘翅目和直翅目为主要优势类群,主要优势种有中华蚱蜢(Acrida cinerca Thunberg)、黑足婪步甲(Harpalus roninus Bate)、榆紫叶甲(Ambrostoma quadriimpressum(Motschulsky)).沙丘榆林生境有11目51科95种,其中,鞘翅目有16科31种;芦苇沼泽生境有9目33科56种,其中,鳞翅目有9科20种;羊草草原生境有8目32科67种,其中,鳞翅目有9科17种.对向海自然保护区主要害虫种类及资源昆虫进行了初步分析.     

Complementation in the composition of steel slag and red mud for preparation of novel ceramics

A method for preparing novel ceramics was developed in this study. Different ratios red muds were added to steel slags to optimize the preparation of novel ceramics by a traditional ceramic preparation process. The sintering mechanism, microstructure, and performance were studied by X-ray diffraction techniques, scanning electron microscopy, and combined experiments of linear shrinkage, water absorption, and flexural strength. The results confirmed that red mud can reduce the volumetric instabilities through the complementarity of red mud and ferroalloy slag. The crystal phases in the ceramics are all pyroxene group minerals, including diopside ferrian, augite, and diopside. The flexural strength of the ceramic that contains 40wt% red mud and was prepared at the optimal sintering temperature (1140℃) is greater than 93 MPa; its corresponding water absorption is less than 0.05%.     

基于容积粒子滤波的交互式多模型算法

针对非线性非高斯条件下目标跟踪容易发散和精度下降等问题,将容积粒子滤波引入到交互式多模型算法中,提出了一种基于容积粒子滤波的交互式多模型算法。该算法在粒子先验分布更新阶段,利用容积卡尔曼滤波器融入最新的观测数据并产生重要性密度函数,使其更加逼近系统真实状态的后验概率密度,改善了粒子滤波的性能。仿真表明在运算时间未显著变化的情况下,该算法与交互式多模型无迹粒子滤波算法相比有着更高的滤波精度和稳定性。     

爆炸冲击波在扁平大空间内的传播规律

为研究爆炸冲击波在地下停车场等扁平大空间内的传播规律，采用AUTODYN软件建立了二维轴对称分析模型，分析了8种质量的TNT在扁平大空间中间位置地面处引爆后冲击波的传播特性。通过结合爆炸冲击波传播云图和部分测点的压力时程曲线，分析发现冲击波在传播过程中会形成多个马赫波，首个马赫波的马赫杆高度可以达到空间净高，后续马赫波的马赫杆高度较小，但传播速率大，最终会追上首个马赫波，并与其汇合，在汇合处峰值超压较马赫杆其他位置有所增加，随着传播距离的增加后续马赫波对首个马赫波的影响越来越小。给出了根据比例净高确定马赫波阵面峰值超压恒定的临界点水平位置和对应最大峰值超压值的计算公式，给出了根据平面比例爆距确定最大峰值超压平均值的计算公式。     

科技型中小企业技术创新的资金支持——基于生命周期视角的研究

基于生命周期的视角分析了科技型中小企业发展过程中各个阶段的特点,以及各个阶段中技术创新与资金支持的矛盾.在新的经济环境与政策条件下,构建了解决这种矛盾的资金支持体系,探讨了企业发展和技术创新过程中具体的融资方式,并且提出了相关的政策建议.     

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative pathways, the result is cellular toxicity and neurodegeneration. Cellular mechanisms for degrading misfolded protein include the ubiquitin-proteasome system (UPS), the main non-lysosomal degradative pathway for ubiquitinated proteins, and autophagy, a lysosome-mediated degradative pathway. The UPS and autophagy have long been viewed as complementary degradation systems with no point of intersection. This view has been challenged by two observations suggesting an apparent interaction: impairment of the UPS induces autophagy in vitro, and conditional knockout of autophagy in the mouse brain leads to neurodegeneration with ubiquitin-positive pathology. It is not known whether autophagy is strictly a parallel degradation system, or whether it is a compensatory degradation system when the UPS is impaired; furthermore, if there is a compensatory interaction between these systems, the molecular link is not known. Here we show that autophagy acts as a compensatory degradation system when the UPS is impaired in Drosophila melanogaster, and that histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase that interacts with polyubiquitinated proteins, is an essential mechanistic link in this compensatory interaction. We found that compensatory autophagy was induced in response to mutations affecting the proteasome and in response to UPS impairment in a fly model of the neurodegenerative disease spinobulbar muscular atrophy. Autophagy compensated for impaired UPS function in an HDAC6-dependent manner. Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner. This study suggests that impairment of autophagy (for example, associated with ageing or genetic variation) might predispose to neurodegeneration. Morover, these findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy.     

Enhanced anti-sunward flow near local noon during a period of horizontal IMF and high solar wind velocity <Emphasis Type="Italic">V</Emphasis><Subscript><Emphasis Type="Italic">Y</Emphasis></Subscript>

It is believed that a southward interplanetary magnetic field (IMF) is mainly responsible for the energy input from solar wind into the magnetosphere. This paper presents an unusual case of strong anti-sunward plasma flow (up to 2 km/s) in the polar cap ionosphere and large cross-polar cap potential (CPCP) during a period of horizontal IMF (|B _Z | < 2 nT) observed by both ACE (at the L1 point) and Geotail (on the dusk flank of the magnetosheath). The CPCP is even higher than that under preceding B _Z ≈ −23 nT. Furthermore, GOES8 observed that the magnetosheath field turns northward as the anti-sunward plasma flow and CPCP start to increase, which implies that the magnetosheath field interacting with the Earth’s magnetopause has significantly rotated and differs from the IMF observed by ACE and Geotail. In accordance with previous theoretical work, we suggest that the magnetic field line draping produces a southward magnetosheath field and enhances anti-sunward plasma flow and the CPCP.     

施工企业防范经营风险初探

施工企业经营风险是指企业在经营中对未来经营环境中的不确定因素与多变性无法全部或精确预测所造成预计支出与收益偏离实际的风险。企业经营风险是在经营过程中产生的,因此,经营风险贯穿于企业生产经营的全过程。