时变时延网络化控制系统的鲁棒稳定性

针对一类存在噪声干扰的时变时延网络化控制系统,基于信息调度与控制协同设计的思想,建立了具有信息调度和噪声干扰的时变时延网络化控制系统模型．引入增广状态矩阵分析方法,研究了存在时变时延和噪声干扰情形下闭环网络化控制系统的鲁棒稳定性问题．给出了使闭环系统渐近稳定的控制器参数化表达式．仿真分析表明该策略在满足闭环系统稳定性的同时,降低了系统信道的数据信息流量,充分地利用了网络带宽资源。     

中国药品集中采购政策解读与实证分析

2018年底伊始的国家药品集中采购迄今为止已实施三轮,共涉及112个品种,预计每年约可节省医保药品支出539亿元.对三轮集中采购规则进行解读和实证分析,发现:选区规则对竞价结果具有显著性影响;熔断机制理论上会受到成本因素约束,实践中仍发挥了一定效果.国家药品集中采购促进了中国医药市场基于质量和成本的竞争,推动行业集中度...     

基于时间窗的SVDBN近似推理算法研究

变结构动态贝叶斯网络(SVDBN)在处理非稳态过程的不确定问题具有其独特的优越性。为克服SVDBN推理算法不能实现在线推理的缺陷,在引入SVDBN的时间窗和时间窗宽度概念基础上,阐述了基于时间窗的SVDBN在线近似推理机制,提出了2种在线近似推理算法,即基于时间窗的变结构离散动态贝叶斯网络(SVDDBN)递推推理算法和基于时间窗的SVDDBN快速推理算法。通过仿真实验验证了这2种算法的有效性,并从复杂度、适用范围及更新时间等方面进行了比较。     

Distributed Second-Order Continuous-Time Optimization via Adaptive Algorithm with Nonuniform Gradient Gains

Journal of Systems Science and Complexity - This paper addresses the distributed adaptive optimization problem over second-order multi-agent networks (MANs) with nonuniform gradient gains. A...     

典型陆军部队装备维修作业能力评估系统仿真建模研究

针对陆军部队维修作业仿真评估需求,提出了一套仿真模型设计方案。分析了部队维修作业能力仿真评估原理,进而明确了评估模型需求;给出了维修任务生成、维修保障系统建模方案;结合备件调度和保障设备使用过程,设计了维修保障资源模型。为陆军部队装备维修作业能力评估提供建模基础,用于支撑部队维修作业能力仿真评估系统的设计和应用案例研究。     

Temperature modeling and control of Direct Methanol Fuel Cell based on adaptive neural fuzzy technology

Aiming at on-line controlling of Direct Methanol Fuel Cell （DMFC） stack, an adaptive neural fuzzy inference technology is adopted in the modeling and control of DMFC temperature system. In the modeling process, an Adaptive Neural Fuzzy Inference System （ANFIS） identification model of DMFC stack temperature is developed based on the input-output sampled data, which can avoid the internal complexity of DMFC stack. In the controlling process, with the network model trained well as the reference model of the DMFC control system, a novel fuzzy genetic algorithm is used to regulate the parameters and fuzzy rules of a neural fuzzy controller. In the simulation, compared with the nonlinear Proportional Integral Derivative （PID） and traditional fuzzy algorithm, the improved neural fuzzy controller designed in this paper gets better performance, as demonstrated by the simulation results.     

国际重要检索系统与甘肃省科技期刊

对国际重要检索系统进行了论述,并对甘肃省科技期刊被国际重要检索系统收录情况进行了统计与分析。     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.