近半个世纪以来中国季风区气温与降水变化及其时空差异

利用中国东部季风区20个测站1960-2012年气温和降水量的月值数据,采用线性趋势分析、Mann-Kendall突变检验、Morlet小波分析等方法,分析了季风区各区域年平均气温和年降水量的变化趋势、突变现象和周期特征.结果表明1960-2012年季风区各区域均有增温趋势,在20世纪90年代发生突变,东北地区发生突变要早于其他地区,北方地区的增温幅度大于南方,存在4年左右周期,8～16年的准周期,气温的高频变化周期在内陆地区表现更为明显;年降水量在53年里处于波动状态,四川盆地、华北地区和季风区西北部地区降水有减少趋势,长江流域下游降水有增加趋势,其他地区没有明显变化趋势,存在2～4年周期、8～16年左右准周期,降水的低频变化周期在近海地区表现更为明显.     

电压源型逆变器改进无差拍控制策略仿真研究

电压源型逆变器广泛运用于UPS、新能源发电等场合,在各种负载下,尤其是非线性负载下的低电压畸变率和快速系统响应是其追求的目标。通过对单相逆变系统进行建模,根据其离散状态空间方程,提出了一种新型无差拍控制策略,在双闭环控制基础上增加了2个前馈环节,并设计了预测状态观测器以消除采样和计算带来的延时,提高系统动态响应能力。在MATLAB/Simulink环境下对单相逆变器改进型无差拍控制策略进行了系统建模,仿真结果表明,该控制策略能显著提高系统在非线性负载下的动态响应性能,改善输出电压波形。     

基于Fluent的钻井纠斜液压系统导向套叶片形状优化选择

建立3种不同叶片截面形状导向套的SolidWorks模型,利用Fluent软件对自动垂直钻井系统导向套井下多相耦合流场进行仿真分析,得到泥浆通过不同叶片截面形状导向套时的流动特性,进而对导向套叶片截面形状进行优化选择。结果表明,旋转导向套采用三角形截面叶片为最佳选择。     

基于演化聚类的社交媒体舆情分析方法综述

当前,社交媒体已经成为人们发布和获取信息的最主要渠道之一。由于大量用户的参与,社交媒体平台上已累计了海量的舆情数据,并且还在以指数级增加。如何发现和跟踪社交媒体中舆情变化是当前数据挖掘领域研究的热点问题之一。基于演化聚类的方法是分析社交媒体舆情的一类主要方法。主要从主题模型和矩阵/张量分解模型两方面来总结当前基于演化聚类的舆情分析方法,并且分析这两类方法的优缺点;最后对下一步研究进行了展望。     

视线追踪系统中注视点估计算法研究

针对非接触式视线跟踪系统中注视点估计算法鲁棒性差的问题,提出一种基于角度映射的注视点估计算法。首先,根据人眼特性及视觉成像原理,瞳孔中心相对于角膜反射光斑的位置与注视点相对于红外光源的位置之间具有一定的角度映射关系,据此估计出注视点近似位置。然后,在眼球模型结构的基础上分析了眼球角膜曲面对注视点造成的偏差,通过弧长对误差进行补偿。最后,利用非线性多项式模型对眼球视轴和光轴之间的偏差进行拟合,得到最终的视线落点。实验证明,该系统具有较高的精度和自由度,在水平和垂直方向上最大误差均小于1 cm。     

计及阶梯式碳交易的综合能源系统优化调度

随着电力市场和碳市场的发展,将需求响应和碳交易机制引入综合能源系统运行调度中,有助于引导用户和系统运营商优化用电和调度计划。通过分时电价和需求响应激励补贴等综合型激励措施引导用户参与需求响应,并基于IGDT（information gap decision theory）理论构建了考虑阶梯式碳交易机制以及需求响应的综合能源系统双层随机优化调度模型,并通过KKT条件和大M法将双层模型转化为单层模型进行求解。结果表明,引入需求响应和阶梯式碳交易机制之后能够实现综合能源系统的低碳环保运行。     

Opportunistic spectrum sharing in software defined wireless network

Over the past few decades, the world has witnessed a rapid growth in mobile and wireless networks（MWNs） which significantly change human life. However, proliferating mobile demands lead to several intractable challenges that MWN has to face. Software-defined network is expected as a promising way for future network and has captured growing attention. Network virtualization is an essential feature in software-defined wireless network（SDWN）, and it brings two new entities, physical networks and virtual networks. Accordingly, efficiently assigning spectrum resource to virtual networks is one of the fundamental problems in SDWN. Directly orienting towards the spectrum resource allocation problem, firstly, the fluctuation features of virtual network requirements in SDWN are researched, and the opportunistic spectrum sharing method is introduced to SDWN. Then, the problem is proved as NP-hardness. After that, a dynamic programming and graph theory based spectrum sharing algorithm is proposed.Simulations demonstrate that the opportunistic spectrum sharing method conspicuously improves the system performance up to around 20%–30% in SDWN, and the proposed algorithm achieves more efficient performance.     

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on gene expression parallel those observed for the histone deacetylases. We demonstrated that F- and Cl-amidine, two potent PAD4 inhibitors, display micromolar cytotoxic effects towards several cancerous cell lines (HL-60, MCF7 and HT-29); no effect was observed in noncancerous lines (NIH 3T3 and HL-60 granulocytes). These compounds also induced the differentiation of HL-60 and HT29 cells. Finally, these compounds synergistically potentiated the cell killing effects of doxorubicin. Taken together, these findings suggest PAD4 inhibition as a novel epigenetic approach for the treatment of cancer, and suggest that F- and Cl-amidine are candidate therapeutic agents for this disease.     

A Note on the Property of ψ-Function

About the accurate value of ψ ( x ) = Γ′ ( x ) / Γ ( x), we know only ψ (1)and ψ (1/ 2).In this paper, by calculating the accurate values of some series expansion of a function and applying some skills of complex analysis, we prove that the expression of the ψ-function admits a finite expression in elementary function for rational number z. As an application, some examples are given.     

The role of endosomal-recycling in long-term potentiation

Long-term potentiation (LTP) defines persistent increases in neurotransmission strength at synapses that are triggered by specific patterns of neuronal activity. LTP, the most widely accepted molecular model for learning, is best characterised at glutamatergic synapses on dendritic spines. In this context, LTP involves increases in dendritic spine size and the insertion of glutamate receptors into the post-synaptic spine membrane, which together boost post-synaptic responsiveness to neurotransmitters. In dendrites, the material required for LTP is sourced from an organelle termed the endosomal-recycling compartment (ERC), which is localised to the base of dendritic spines. When LTP is induced, material derived from the recycling compartment, which contains α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-type glutamate receptors (AMPARs), is mobilised into dendritic spines feeding the increased need for receptors and membrane at the spine neck and head. In this review, we discuss the importance of endosomal-recycling and the role of key proteins which control these processes in the context of LTP.