55CrSiA与JIS G3566—77油淬火弹簧钢丝的比较分析

在系统地对同规格的５５ＣｒＳｉＡ与ＪＩＳ Ｇ３５６６－７７油淬火钢丝的成分、组织、残留元素及力学性能进行了复查，并按相同工艺制成ＦＭ１４７发动机气阀弹簧做了比较试验后发现：该种弹簧钢丝与日本弹簧钢丝在质量上略有差距。     

有机颜料晶体行为和颜色性能的关系——Ⅰ.联苯胺系黄色颜料

合成了系列联苯胺系黄色双偶氮颜料。采用X-射线粉末衍射枝术考察了它们的晶体行为,并关联了其颜色性能。发现C.I.颜料黄14和63为异质同晶体,C.I.颜料黄17存在同质多晶现象。测色结果表明:颜料的晶体行为对颜料的颜色性能具有重大影响。     

用荷瘤裸鼠模型研制抗人肝癌单克隆抗体

1985年Watanabe等报道:用去胸腺载瘤小鼠的脾细胞与小鼠骨髓瘤细胞SP 2/0融合获得抗结肠癌单克隆抗体之后,利用荷瘤裸鼠模型成功研制抗人肿瘤单抗的报道已相继出现:但所获单抗多为IgM,IgG类的单抗得率不高,本工作采用多次手术大部切除瘤块的方法延长荷瘤裸鼠的成活期,获得一株抗人肝癌IgG类单抗、其研制过程和结果报道如下。     

Engineering a mouse balancer chromosome.

Balancer chromosomes are genetic reagents that are used in Drosophila melanogaster for stock maintenance and mutagenesis screens. Despite their utility, balancer chromosomes are rarely used in mice because they are difficult to generate using conventional methods. Here we describe the engineering of a mouse balancer chromosome with the Cre-loxP recombination system. The chromosome features a 24-centiMorgan (cM) inversion between Trp53 (also known as p53) and Wnt3 on mouse chromosome 11 that is recessive lethal and dominantly marked with a K14-Agouti transgene. When allelic to a wild-type chromosome, the inversion suppresses crossing over in the inversion interval, accompanied by elevated recombination in the flanking regions. The inversion functions as a balancer chromosome because it can be used to maintain a lethal mutation in the inversion interval as a self-sustaining trans-heterozygous stock. This strategy can be used to generate similar genetic reagents throughout the mouse genome. Engineering of visibly marked inversions and deficiencies is an important step toward functional analyses of the mouse genome and will facilitate large-scale mutagenesis programs.     

A Novel Multi-Level Trust Algorithm for Mobile Ad Hoc Networks

Firstly, a multilevel trust algorithm for MANET （mobile ad hoe networks） is presented in this paper and the trust level is defined as a three-tuple type in this multilevel trust algorithm. The paper introduces the multilevel trust into MANET, thereby controlling restricted classified information flows among nodes that have different trust levels. Secondly, the infrastructure of MANET that suit to our multi-level trust is presented, Some conclusions are given at lastly.     

小型轴流定桨式水轮机的技术改造

通过对几座多泥沙河流上小型轴流定桨式电站的技术改造，表明，蜗壳式电站中的水润滑橡胶轴承可以容易地改造为稀油润滑轴承；容量匹配不合理的电站可以把1台机组的转轮更换为适宜于小流量发电的低比速转轮；转轮型号不妥的电站应重新设计与水力参数相符的转轮。这些合理、简便、经济的手段，可大幅提高电站的发电量和经济效益。     

伯胺И_(1923)从硫代硫酸钠-亚硫酸钠介质中萃取银的研究

研究了用伯胺N_(1928)从Ha_2S_2O_3-Na_2SO_3介质中萃取银的机理.由于S_2O_3~(2-)易被氧化.因此萃取时不应有氧化性离子如NO_8~-等存在,并且要加入Na_2SO_3作稳定剂.此外,有机相伯胺的硫代硫酸盐也是临用时制备的.萃取的最适合pH在3.5～6.0.萃合物的组成用4种方法测定:即Job氏法,饱和容量法,斜率法与饱和有机相的化学分析.它们都表明萃合物组成为(RNH_3)_5Aga(S_2O_3)_4.用红外光谱研究了被萃阴离子的结构,说明该阴离子为折线状,测得该反应的热力学函数为logKex=27.05.△H°=-49.3J/mol,△G°=-141.3/kJmol与△S°=517.1J/mol·K。     

关于方程+f+h+g(x)=0的全局稳定性

讨论了较一般的三阶非线性微分方程零解的全局稳定性,给出其全局稳定性的充分准则。     

A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice

The pathophysiologic pathways and clinical expression of mitochondrial DNA (mtDNA) mutations are not well understood. This is mainly the result of the heteroplasmic nature of most pathogenic mtDNA mutations and of the absence of clinically relevant animal models with mtDNA mutations. mtDNA mutations predisposing to hearing impairment in humans are generally homoplasmic, yet some individuals with these mutations have severe hearing loss, whereas their maternal relatives with the identical mtDNA mutation have normal hearing. Epidemiologic, biochemical and genetic data indicate that nuclear genes are often the main determinants of these differences in phenotype. To identify a mouse model for maternally inherited hearing loss, we screened reciprocal backcrosses of three inbred mouse strains, A/J, NOD/LtJ and SKH2/J, with age-related hearing loss (AHL). In the (A/J x CAST/Ei) x A/J backcross, mtDNA derived from the A/J strain exerted a significant detrimental effect on hearing when compared with mtDNA from the CAST/Ei strain. This effect was not seen in the (NOD/LtJ x CAST/Ei) x NOD/LtJ and (SKH2/J x CAST/Ei) x SKH2/J backcrosses. Genotyping revealed that this effect was seen only in mice homozygous for the A/J allele at the Ahl locus on mouse chromosome 10. Sequencing of the mitochondrial genome in the three inbred strains revealed a single nucleotide insertion in the tRNA-Arg gene (mt-Tr) as the probable mediator of the mitochondrial effect. This is the first mouse model with a naturally occurring mtDNA mutation affecting a clinical phenotype, and it provides an experimental model to dissect the pathophysiologic processes connecting mtDNA mutations to hearing loss.