A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Behavior Model Construction for Client Side of Modern Web Applications

Most of the behavior models with respect to Web applications focus on sequencing of events,without regard for the changes of parameters or elements and the relationship between trigger conditions of events and Web pages.As a result,these models are not sufficient to effectively represent the dynamic behavior of the Web2.0 application.Therefore,in this paper,to appropriately describe the dynamic behavior of the client side of Web applications,we define a novel Client-side Behavior Model(CBM) for Web applications and present a user behavior trace-based modeling method to automatically generate and optimize CBMs.To verify the effectiveness of our method,we conduct a series of experiments on six Web applications according to three types of user behavior traces.The experimental results show that our modeling method can construct CBMs automatically and effectively,and the CBMs built are more precise to represent the dynamic behavior of Web applications.     

环境标准的现状与作用分析

介绍了我国环境标准的基本现状,对我国环境标准的制定目的、作用作了阐述,指出环境标准对环境保护的重要性.     

阶段原型法及其支持环境

本文介绍了阶段原型法(SPA)及其支持环境(PEMIS)的总体结构和主要功能,探讨了知识库和推理机制在循环控制中的作用,以及软件重用技术、图形接口技术和应用生成技术等实现技术。     

Immune biology of Ag-specific γδ T cells in infections

Accumulating evidence suggests that human γδ T cells act as non-classical T cells and contribute to both innate and adaptive immune responses in infections. Vγ2 Vδ2 T (also termed Vγ9 Vδ2 T) cells exist only in primates, and in humans represent a dominant circulating γδ T-cell subset. Primate Vγ2 Vδ2 T cells are the only γδ T cell subset capable of recognizing microbial phosphoantigen. Since nonhuman primate Vγ2 Vδ2 T cells resemble their human counterparts, in-depth studies have been undertaken in macaques to understand the biology and function of human Vγ2 Vδ2 T cells. This article reviews the recent progress for immune biology of Vγ2 Vδ2 T cells in infections.     

Correlations for the ignition delay times of hydrogen/air mixtures

Correlations for the ignition delay times of hydrogen/air mixtures were developed using the method of High Dimensional Model Representation (HDMR).The hydrogen/air ignition delay times for initial conditions over a wide range of temperatures from 800 to 1600 K,pressures from 0.1 to 100 atm,and equivalence ratios from 0.2 to 10 were first calculated utilizing the full chemical mechanism.Correlations were then developed based on these ignition delay times.Two forms of correlations were constructed:the first one is an overall general model covering the whole range of the initial conditions;while the second one is a piecewise correlation model valid for initial conditions within different sub-domains.The performance of these correlations was studied through comparison with results from the full chemical mechanism as well as experimental data.It was shown that these correlations work well over the whole range of initial conditions and that the accuracy can be significantly improved by using different piecewise correlations for different sub-domains.Therefore,piecewise correlations can be used as an effective replacement for the full mechanism when the prediction of chemical time scale is needed in certain combustion modeling.     

一种基于深度学习的移动端隐写方法

隐写是隐蔽通信的主流方法之一,而移动端则是当下最常用的通信设备,二者的结合研究具有较高的实际意义.近年来,基于深度学习的隐写方法得到快速发展,然而在性能提升的同时,各类网络结构向着更复杂、庞大的方向演变,逐渐脱离以隐蔽通信为核心的实际应用场景,实用性较低.针对这一现象,本文提出一种适用于移动端的轻量级图像隐写方法.对网络整体进行轻量化设计,结合深度可分离卷积降低模型计算量,在精度和速度之间取得较好的折中平衡.以生成对抗网络的思想,将编码器、解码器和判别器构成的整体模型纳入对抗训练中,使子网络在迭代对弈中实现螺旋式上升发展.为应对真实环境下的各类挑战,模型被落地部署于移动设备上进行真机实验.在移动端,精简后的模型性能会出现小幅下降.对此,在方法中引入BCH纠错码以确保正确提取信息.实验结果表明,该移动端隐写方法生成图像质量好,且具有较高的响应速度,能满足现代社会中人们对便捷性的高要求.值得注意的是,该方法的所有计算工作均可在移动端独立完成,不需要通过网络请求服务器,能避免网络窃听攻击.     

Nanostructured TiO2（B）:the effect of size and shape on anode properties for Li-ion batteries

Reducing the dimensions of electrode materials from the micron to the nanoscale can have a profound influence on their properties and hence on the performance of electrochemical devices,e.g.Li-ion batteries,that employ such electrodes.TiO2(B) has received growing interest as a possible anode for Li-ion batteries in recent years.It offers the possibility of higher energy storage compared with the commercialized Li4Ti5O12.Bulk,nanowire,nanotube,and nanoparticle morphologies have been prepared and studied.However,to date these materials have not be compared in one article.In the current review we first summarize the different synthesis methods for the preparation of nanostructured TiO2(B);then present the effects of size and shape on the electrochemical properties.Finally TiO2(B) with nanometer dimensions exhibit a higher capacity to store Li,regardless of rate,due to structural distortions inherent at the nanoscale.