关于方程+f+h+g(x)=0的全局稳定性

讨论了较一般的三阶非线性微分方程零解的全局稳定性,给出其全局稳定性的充分准则。     

A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice

The pathophysiologic pathways and clinical expression of mitochondrial DNA (mtDNA) mutations are not well understood. This is mainly the result of the heteroplasmic nature of most pathogenic mtDNA mutations and of the absence of clinically relevant animal models with mtDNA mutations. mtDNA mutations predisposing to hearing impairment in humans are generally homoplasmic, yet some individuals with these mutations have severe hearing loss, whereas their maternal relatives with the identical mtDNA mutation have normal hearing. Epidemiologic, biochemical and genetic data indicate that nuclear genes are often the main determinants of these differences in phenotype. To identify a mouse model for maternally inherited hearing loss, we screened reciprocal backcrosses of three inbred mouse strains, A/J, NOD/LtJ and SKH2/J, with age-related hearing loss (AHL). In the (A/J x CAST/Ei) x A/J backcross, mtDNA derived from the A/J strain exerted a significant detrimental effect on hearing when compared with mtDNA from the CAST/Ei strain. This effect was not seen in the (NOD/LtJ x CAST/Ei) x NOD/LtJ and (SKH2/J x CAST/Ei) x SKH2/J backcrosses. Genotyping revealed that this effect was seen only in mice homozygous for the A/J allele at the Ahl locus on mouse chromosome 10. Sequencing of the mitochondrial genome in the three inbred strains revealed a single nucleotide insertion in the tRNA-Arg gene (mt-Tr) as the probable mediator of the mitochondrial effect. This is the first mouse model with a naturally occurring mtDNA mutation affecting a clinical phenotype, and it provides an experimental model to dissect the pathophysiologic processes connecting mtDNA mutations to hearing loss.     

基于单片机的超声波测距设计与研究

基于单片机的超声波测距仪。借助压电式陶瓷传感器TCT40-10F/S(1),其适用范围:家用电器和其他电子设备的遥控装置;超声测距,车辆倒车防撞报警装置。     

Suppressing progress of pancreatitis through selective inhibition of NF-κB activation by using NAC

OBJECTIVE: To explore the characteristics of NF-KappaB activation in the progress of pancreatitis, the relationship with expression of TNF-alpha in the inflammatory reaction, and prevent the exacerbation of pancreatitis by using NAC. METHOD: Forty-eight rats were divided into three groups: therapy (group C), pancreatitis (group B) and control (group A). NAC served as the inhibitor of NF-KappaB activation. In the time intervals of 1.5, 3.0, 6.0, 12.0 hour, NF-KappaB activation was detected with flow cytometry (FCM) and the expression of TNF-alpha mRNA and protein with in situ hybridization (ISH) and enzyme-linked immuno-sorbent assay (ELISA) respectively. Meanwhile, the level of lipase and amylase in the serum was assayed and the pathological change was evaluated. RESULT: NF-KappaB activation in the pancreatitis group was higher than that in the control group (P<0.01), peaked at 3 hours, and was depressed by the inhibitor of NF-KappaB, NAC. The expression of TNF-alpha as well as the level of lipase and amylase in the serum also rose synchronously with activation of NF-KappaB. In contrast to group A, it was significantly different (P<0.01) in group B. After using NAC in group C, all of these values were decreased and the inflammatory reaction in the pancreas abated evidently. The pathology changes of the pancreas were shown to be alleviated in group C. CONCLUSION: First, NF-KappaB activity is intensively initiated in the course of pancreatitis and shown to have closely relationship with the release of cytokines. Second, use of NAC markedly depressed NF-KappaB activation. TNF-alpha expression is down regulated by cytokines. It is suggested that NAC probably acts as a useful agent for treatment of pancreatitis by indirectly inhibiting activation of NF-KappaB.     

空中交通延误预测研究综述

空中交通系统作为典型复杂系统,其非线性聚合的动力学特征给延误预测带来挑战,使空中交通延误预测问题保持了开放性.近二十年来,针对此问题,利用传统机器学习、深度学习、复杂系统建模仿真、排队理论等,涌现出大量研究成果.首先系统性阐述了空中交通延误产生与传播的原因,并根据预测数值类型、预测对象以及预测时间尺度对现有研究中的延误...     

多变量自校正控制计算机辅助设计软件系统

本文介绍了一个可帮助用户进行多变量自校正控制系统设计,而使用户不必了解算法细节的计算机辅助设计(CAD)软件系统;它既包括一些经典的自校正控制算法,又引入了一些近年来新研究的成果。使用情况表明,该系统算法先进,使用方便,控制效果较好,是一个实用的软件工具。     

混沌视角下的学校管理职能改善研究

混沌理论已运用到教育领域。学校面临外部环境复杂性、学校管理目标的多维性、学校内部存在自发的混沌行为,决定学校管理中必然存在混沌现象。对学校的计划、组织、领导和控制这四大管理职能中混沌现象进行审视,并利用混沌管理理论与方法提出相应绩效改进措施。     

黄河决徙与黄河冲积扇发育关系初探

在论证黄河冲积扇仍处于建造时期当中,得出决徙是建扇过程发生的自然现象.下游河道历史上两期安流跟两期暖湿气侯背景的出现不无联系.治河方向应以滞缓建扇过程和保护河口海岸为原则,这样才符合自然规律.     

岭南传统观演空间的视觉分析

通过对以神庙剧场为代表的岭南传统观演空间的视分析（包括城市空间的视觉分析和观演空间的视线分析），揭示岭南传统观演空间形态的规律和生存的双重意义，从而为研究岭南传统观演空间开辟一个理性的分析方法，并对现代剧场和城市公共空间的设计提供参考．