A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Supply chain performance for deteriorating items with cooperative advertising

To study the effect of cooperative advertising on the supply chain of deteriorating items, this paper establishes a Stackelberg game model for a two-echelon deteriorating items supply chain composed of one manufacturer and one retailer under a given support program with an exogenous participation rate. The manufacturer as the leader determines the wholesale price and production rate, and the retailer as the follower determines the retail price and advertising strategies. The strategies of the players under the decentralized scenario and the centralized scenario are respectively characterized. Numerical simulations and sensitivity analysis are conducted to gain some managerial insights. It is shown that the pricing, advertising and production strategies are negatively correlated to deteriorating coefficient, and both the profit and the channel efficiency decrease with deteriorating coefficient; The interaction between price, advertising investment and production rate results in a higher retail price of the centralized channel compared to that of the decentralized channel; Implementing the cooperative advertising program does improve the performance of the supply chain in some cases and the participation rate roughly at 0.5 is most preferable, but it is also possible to distort incentive and damage the channel performance when the participation rate reaches a relatively high level.     

建立支持宏观经济决策研讨厅的预测模型系统

为了提高对宏观经济问题的研讨效率,研讨厅应为参加研讨的专家提供进行宏观经济预测的各种预测模型。然而,传统模型库结构框架建立的预测模型系统,已不能很好地满足支持宏观经济决策研讨厅的要求,本文从分析研讨厅的具体需要出发,提出了利用Agent理论和技术设计和实现适合支持宏观经济决策研讨厅的Agent预测模型系统。     

Fairness of extra-gain guilty in performance of supply chain and contract design

Considering a one-supplier and two-retailer supply chain setting in which the supplier makes contacts with retailers in sequence based on FCFS(first–come–first-service) principle, the authors investigate the marginal effect of extra-gain guilty fairness concerns of supply chain members on the contract design, supply chain's profit and profit distribution. When the supplier considers distributional fairness of loss aversion and extra-gain guilty, extra-gain guilty concern reduces the optimal wholesale and retail price, and improves supply chain performance. When the first or the second retailer considers distributional fairness and peer-induced fairness, extra-gain guilty concerns decrease the optimal wholesale and retail price but increase the profit of all supply chain members only when the level of loss aversion is large enough and the level of extra-gain guilty is less than 1/2. However, when the level of loss aversion is small and the level of extra-gain guilty is less than 1/2, extra-gain guilty has no influence on supply chain performance. The analysis reveals that the supply chain performance can be further improved by considering fairness of extra-gain guilty.     

Hydrothermal synthesis and photoluminescence behavior of CeO<Subscript>2</Subscript> nanowires with the aid of surfactant PVP

Well-crystalline CeO₂ nanowires were prepared via a surfactant-assisted hydrothermal process. Reaction temperature and reaction time were changed for the determination of optimal synthesis parameters. The as-obtained products were characterized by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), and field emission scanning electron microscopy (FESEM). The results show that single crystal CeO₂ nanowires with high yield and good uniformity can be obtained hydrothermally at 180°C for 12 h with the aid of 2.0 g surfactant (polyvinyl pyrrolidone, PVP). The role of PVP was then discussed and a possible growth mechanism was proposed. Moreover, room temperature photoluminescence (PL) spectra were obtained for these CeO₂ nanowires, which are believed to be related to the abundant defects in these nanostructures.     

大学英语《综合教程》的特色与教学组织模式

文章介绍并分析了新世纪大学英语系列教材之主干课程《综合教程》编写的宗旨和特色,探讨了在教学实践中如何贯彻《综合教程》的编写宗旨,彰显其特色,以取得良好的教学效果。     

Low power and high speed explicit-pulsed double-edge triggered level converting flip-flop

Variable supply voltage-clustered voltage scaling (VS-CVS) scheme can be very effective in reducing power consumption of CMOS circuits without degrading system performance. Level converting flip-flops (LCFFs) are key elements in the CVS scheme. In this paper, a new explicit-pulsed double-edge triggered level converting flip-flop (nEP-DET-LCFF) is proposed, which employs double-edge triggering technique, dynamic structure, explicit pulse generator,conditional discharge technique and proper arrangement of stacked nMOS transistors to efficiently perform latching and level converting functions simultaneously. The proposed nEP-DET-LCFF combines merits of both conventional explicit-LCFFs and implicit-LCFFs. Simulation shows the proposed nEP-DET-LCFF has improvement of 19.2%～46% in delay, and 19.4%～52.9% in power-delay product (PDP) as compared with the published LCFFs.     

基于C/S结构的城市公交监控系统设计

介绍了一种基于C/S结构的城市公交车监控系统,阐述了在Delphi编程环境下如何利用socket编程机制实现客户端与服务器的数据交换,实现了城市公交监控系统的设计。     

Theoretical analysis of reactive solid-liquid interfacial energies

The characterization of reactive solid-liquid interfacial energies and solid surface energies is a pressing problem in materials science and surface science. Based on the concept that unbalanced forces doing work, a mathematical formulation between surface energies and interfacial energies for reactive wetting is presented. The resulting formalism has significant generality in which the equilibrium Young’s equation for solid-liquid interfacial energies is just a special case. It is shown that a solid-liquid interfacial energy at non-equilibrium is always higher than that at equilibrium, and that the transformation of reactive interfaces to equilib-rium interfaces is an inevitable, spontaneous process. The numerical range of solid-liquid interfacial energies γsl for a limited, solid-liquid interfacial wetting system was calculated to be 0 ≤γsl ≤γsg. The calculation methods for reactive solid-liquid interfacial energies and solid surface energies are presented. They are significant for composite materials and weld, powder sinter, package of electronic devices, and other surface and interfacial issues in metallurgy.     

浅谈海相软土地基水泥搅拌桩施工技术

文章结合广珠铁路珠海段海相沉积的软土地基加固,详细阐述水泥搅拌桩工程试桩、施工工艺、施工注意事项、施工质量检验等环节的技术要求和控制措施.