月地高速再入返回飞行器陀螺在轨自主标定技术研究及实现

针对包含非正交安装陀螺的捷联惯导平台轻量化自主对准问题,建立了非正交陀螺组误差模型,提出一套基于最小二乘法的标定算法和地面试验验证方法,在计算能力受限的情况下完成了高精度在轨标定.地面数学仿真和试验验证结果表明,该方法与扩展卡尔曼滤波法精度相当,计算量却大幅减小.在此基础上,通过对标定算法进行逻辑设计,实现了在轨多组陀螺同步容错和标定.该方法已成功应用于探月工程三期月地高速再入返回飞行器的实际飞行,实现了2套惯性导航平台的高精度初始姿态同步对准.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects with melanoma, 7,618 control subjects; United States 1: 1,804 subjects with melanoma, 1,026 control subjects; United States 2: 585 subjects with melanoma, 6,500 control subjects). The combined meta-analysis of all case-control studies identified a new susceptibility locus at 1q21.3 (rs7412746, P = 9.0 × 10(-11), OR in combined replication cohorts of 0.89 (95% CI 0.85-0.95)). We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)). The associated variants at the 1q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

基于HJ-1B卫星的作物秸秆提取及其焚烧火点判定模式

作物秸秆焚烧产生的气体和颗粒物严重污染大气环境,威胁人类健康,给交通带安全带来隐患,利用遥感技术优势监管秸秆焚烧火点具有重要的现实意义.文中基于HJ-1B卫星CCD多光谱遥感数据和IRS热红外遥感数据,以中国江苏中东部为研究区,开展作物秸秆提取及其焚烧火点判定的一体化研究.根据秸秆的光谱特征研究建立了秸秆乘积指数(SMI),结合其纹理信息可从HJ-1BCCD遥感图像上快速有效的提取出秸秆分布,继之结合修正后的火点探测算法可对HJ-1BIRS遥感数据进行火点提取.在秸秆分布和火点探测结果矢量化的基础上,通过GIS技术进行火点叠置分析,可有效地判定作物秸秆火点分布,同时结合实地调研及与MODIS火点产品比对分析验证评价了本研究方法的可行性和有效性.     

Behavior Model Construction for Client Side of Modern Web Applications

Most of the behavior models with respect to Web applications focus on sequencing of events,without regard for the changes of parameters or elements and the relationship between trigger conditions of events and Web pages.As a result,these models are not sufficient to effectively represent the dynamic behavior of the Web2.0 application.Therefore,in this paper,to appropriately describe the dynamic behavior of the client side of Web applications,we define a novel Client-side Behavior Model(CBM) for Web applications and present a user behavior trace-based modeling method to automatically generate and optimize CBMs.To verify the effectiveness of our method,we conduct a series of experiments on six Web applications according to three types of user behavior traces.The experimental results show that our modeling method can construct CBMs automatically and effectively,and the CBMs built are more precise to represent the dynamic behavior of Web applications.     

偏最小二乘法用于近红外漫反射光谱测定异福片

应用近红外漫反射光谱结合偏最小二乘法(NIR PLS)对异福片中利福平和异烟肼的含量进行定量分析, 所建立的定量分析模型对校正集样品中利福平和异烟肼的含量预测回归系数分别为0.992　77,0.989　01,交互验证均方根误差(RMSECV)分别 为0.006　65,0.004　23.对预测集样品利福平、 异烟肼的含量预测均方根误差(RMSEP)分别为0.005　73,0.003　79;加样平均回收率分别为99.376%和98.243%;重现性实验相对标准偏差(RSD)分别为0.679　3%和0.639　8%.结果表明, 该方法预测精度高, 且具有方便快捷、 非破坏、 无污染、 可在线检测、 重现性好等优点, 可作为异福片原位质量检测和在线质量监控的方法予 以推广.     

混合约束非凸规划拟锥条件下的同伦方法

使用同伦算法研究混合约束的非凸非线性规划问题. 当规划问题为混合约束（带有等式约束）时, 可行域变成一个边界区域, 并没有内点. 通过对可行域定义新的拟锥条件, 给出相应同伦方程, 并证明此同伦算法在此拟锥条件下具有全局收敛性.     

一类无约束优化问题的非单调谱共轭梯度方法

结合文献[5]给出的求解非线性无约束优化问题的新公式βkWYL=[gTk(gk-‖gk‖/‖gk-1‖gk-1)]/gk-1Tgk-1提出了一种新的非单调谱共轭梯度法,证明算法具有全局收敛性,并进行数值试验.数值试验结果表明,该方法具有良好的计算效能,特别适合于求解大规模无约束优化问题.     

路网车流径路优化调整中的最短径路算法

目前铁路车流径路基本上都是按照路网的最短路径来安排的,首先一般都采用Dijkstra算法计算最短路径,然后参考相应区段的能力限制,对车流进行分配,对车流量超过能力的区段重新进行车流调整,这时需要重新计算新条件下两点间最短路径,一般仍采用Dijkstra算法重新计算两点最短路径,这大大地浪费了前期的计算最短路径的信息,增加了计算工作量,本文采用A*算法作为一种启发式算法,可以克服这一缺陷。