某型重机枪身管的多物理场耦合分析

为了研究具有不同厚度铬涂层的某型重机枪身管在高温、高压、高速火药流体作用下的温度场和应力场,采用基于多物理场耦合程序接口MpCCI联合结构计算软件Abaqus和流体计算软件Fluent进行耦合计算的方法,对涂层厚度分别为0.28mm、0.35mm、0.41mm的身管进行流-固-热多物理场耦合仿真计算。通过计算得到了不同铬涂层厚度下身管应力和温度的分布规律。结果表明,借助MpCCI联合Abaqus和Fluent进行多物理场耦合计算的方法是可行的;随着涂层厚度的增加身管内壁的温度和应力依次降低,但在涂层与身管结合处的集中应力逐渐增大。结论对身管的结构设计和寿命预测有一定的指导意义。     

有阻尼多跨连续梁在横向激励下的响应

为研究有阻尼多跨连续梁在横向激励下的位移响应,采用整体分析的方法,在BernoulliEuler梁理论的基础上建立求解连续梁的横向振动方程,求得了有阻尼多跨连续梁的位移响应函数,同时求得了有阻尼条件下的固有频率方程和振型函数。     

介质流向对截止阀流场和流阻特性的影响

为探索介质流向对截止阀内部流场和流阻特性的影响,应用SOLIDWORKS软件建立截止阀的三维模型。使用Fluent软件中的有限元法和标准k-ε湍流模型,在不同开度的情况下,采用数值模拟分析的方法,研究不同介质流向下截止阀的流场和流阻特性,分析阀体内部的速度和压力分布规律。结果表明:在两种不同的流向下,阀门的流通能力相差较小;在小开度时,介质高进低出时能够减小阀门的压力损失,在流通高压介质的情况下,高进低出的流向能够极大的减小阀门的关闭力。流场的分析为截止阀的结构设计和优化提供参考。     

FGM圆板考虑面内振动的动态响应

为研究考虑面内振动时FGM圆板的动态响应,首先基于经典板理论,同时考虑横向振动和面内振动,并利用Hamilton原理推导出轴对称情况下功能梯度材料圆薄板线性自由振动的控制方程。采用打靶法对无量纲控制方程进行数值求解,并将方程退化为一般均质板,求解其固有频率,得到了与相关文献非常接近的结果。对具体问题的数值结果进行对比分析,结果表明,面内振动会影响FGM圆板振动频率大小,忽略面内振动的影响会过高估计FGM板的频率。     

The emerging link between O-GlcNAcylation and neurological disorders

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is involved in the regulation of many cellular cascades and neurological diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke. In the brain, the expression of O-GlcNAcylation is notably heightened, as is that of O-linked N-acetylglucosaminyltransferase (OGT) and β-N-acetylglucosaminidase (OGA), the presence of which is prominent in many regions of neurological importance. Most importantly, O-GlcNAcylation is believed to contribute to the normal functioning of neurons; conversely, its dysregulation participates in the pathogenesis of neurological disorders. In neurodegenerative diseases, O-GlcNAcylation of the brain’s key proteins, such as tau and amyloid-β, interacts with their phosphorylation, thereby triggering the formation of neurofibrillary tangles and amyloid plaques. An increase of O-GlcNAcylation by pharmacological intervention prevents neuronal loss. Additionally, O-GlcNAcylation is stress sensitive, and its elevation is cytoprotective. Increased O-GlcNAcylation ameliorated brain damage in victims of both trauma-hemorrhage and stroke. In this review, we summarize the current understanding of O-GlcNAcylation’s physiological and pathological roles in the nervous system and provide a foundation for development of a therapeutic strategy for neurological disorders.     

Melatonin and mitochondrial function during ischemia/reperfusion injury

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin’s protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

月地高速再入返回飞行器陀螺在轨自主标定技术研究及实现

针对包含非正交安装陀螺的捷联惯导平台轻量化自主对准问题,建立了非正交陀螺组误差模型,提出一套基于最小二乘法的标定算法和地面试验验证方法,在计算能力受限的情况下完成了高精度在轨标定.地面数学仿真和试验验证结果表明,该方法与扩展卡尔曼滤波法精度相当,计算量却大幅减小.在此基础上,通过对标定算法进行逻辑设计,实现了在轨多组陀螺同步容错和标定.该方法已成功应用于探月工程三期月地高速再入返回飞行器的实际飞行,实现了2套惯性导航平台的高精度初始姿态同步对准.