Free and membrane-bound ribosomes in maturing neurones of the chick and their possible functional significance

Zusammenfassung Die Histogenese sowie die Anordnung und Verteilung der Nissl-Substanz wurde an ausreifenden Neuronen des Hühnchenrückenmarks licht- und elektronenmikroskopisch untersucht. In den ersten Phasen der Neurogenese wurden nur freie Ribosome im Cytoplasma aufgefunden. Mit fortschreitender Reifung bilden sich erste Profile des endoplasmatischen Retikulums aus, die spärlich mit Ribosomen besetzt sind. Diese Befunde werden funktionell ausgedeutet.

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This paper is based on an investigation in progress which will be submitted byJ. Eschner in partial fultillment of the requirements for the degree of Doctor of Medicine.     

Störung der Atemmotorik durch Parasympathicomimetica,verglichen mit der Wirkung von Reizstoffen Reizstoffen

Summary In experiments on mice, it was found, that the peculiar disturbance of respiratory movements which was demonstrated formerly as the effect of injected reflexogenic irritants (Veratrin, Veratrum-alcaloids, Andromedotoxin etc.), as well as of airborne irritant gases, can also be produced by suitable doses of parasympathicomimetic bronchoconstrictors (Prostigmin, Mestinon, Paraoxon, Parathion, Physostigmin). This confirms the explanation of the phenomenon formerly given by the authors as a reflex reaction initiated by a brief bronchoconstriction.     

Effect of acetylsalicylic acid on iron absorption in the rat

Summary The in vivo administration of⁵⁹Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.This work was supported by Grant No. 6638 from CONICET (Argentina).The technical assistance of Mrs María E. Castro and Mrs Patricia Dubra is gratefully acknowledged.     

Modification of clonazepam anticonvulsive activity by its association with other anti-epileptic drugs

Summary The modification of the anti-epileptic activity of clonazepam by other anticonvulsivants is studied. The results vary according to the drug and technique used. The usefulness of the 2 techniques employed is discussed.