The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

基于多变量希尔伯特频域模型的癫痫发作预测

癫痫发作具有突发性和反复性,对患者生命安全构成巨大威胁.为了对癫痫发作进行有效地预测,提出了多变量希尔伯特频域模型的癫痫发作预测方法.将希尔伯特边际谱、希尔伯特边际谱的变化方向和希尔伯特加权频率组成一个三维特征向量作为多变量希尔伯特频域模型,输入到支持相量机中,实现癫痫的发作预测,最后采用癫痫发作预测特征方法对预测结果进行评估.实验结果表明:采用多变量希尔伯特频域模型分析方法预测δ波和θ波的癫痫发作,癫痫预测范围在30~45 min,患者有足够的时间采取措施应对;癫痫发作周期在5~10 min,缩短患者等待时间,降低焦虑程度;与多种相关方法进行比较,该方法具有较低的错误预报率和较高的预测敏感度.     

对高职数控专业毕业综合实训的探讨

本文探讨了数控技术专业毕业综合实训的改革思路，提出按职业资格标准强化技能培训，使学生在毕业前获得数控机床操作职业资格证书，切实提高学生的职业素质与就业竞争能力。     

现代教学媒体及其应用的探讨

教学媒体是现代教育技术的重要组成部分，它是人类社会发展的成果之一，文章对各类现代教学媒体进行了探讨。     

科技创新获利能力形成机理研究

科技创新已成为影响企业获利和社会经济增长的关键性因素。在对科技创新获利能力的形成动因厦路径进行详细分析的基础上，对其形成过程中的规律及效果进行了深入的研究与评价．并运用指标体系法构建起科技创新获利能力形成评价体系．对科技创新获利能力的增强提供了理论依据与指导．具有一定的前瞻性和可行性。     

增加农民收入刍议

农民的收入水平不仅与农村居民的生活状况密切相关,而且关系到农村经济以及整个国民经济的发展。千方百计地增加农民收入,是我国当前农村工作的主要任务。积极地发展大城市是增加农民收入的有效途径之一。     

Empirical Test for Earnings Management of Top Managers＇ Change in Listed Companies

Top managers play a significant role on business decision in listed companies. The frequency of top managers＇ change is rather high all along. Whether those listed companies which top managers changed can really improve performances？ In this paper, we will discuss whether listed companies improve the financial index through earning management and give some advice on top managers＇ change in listed companies in China.     

基于PLC的LED显示电路的研究

介绍了几种LED显示电路．为减少硬件设置，节省PLC的I／0点，提高系统的性价比具有积极的意义．该显示电路在设计中已应用，实践证明是可行的，值得推广．     

建构高职毕业生质量评价体系的方式

通过构建高职毕业生质量评价体系，对毕业生质量进行评价，可以了解到毕业生在工作中的表现、取得的成绩、存在的问题，以及用人单位对毕业生质量的满意程度等，以便为高职院校的教育改革提供信息，最终保证并促进高职毕业生整体质量的提高。     

基于B/S模式的水利水电工程造价管理系统研究

提出了基于B／S模式的水利水电工程造价管理系统，对B／S的体系结构、系统的总体结构设计、功能及功能设计进行了阐述，并说明了系统实现的关键技术．