集成化CAD／CAM系统

论述了CAD／CAM系统集成技术。从CAD／CAM系统集成方法、CAD／CAM系统集成的关键技术，以及基于特征的产品模型建立等方面对CAD／CAM系统集成技术进行了探讨。     

δ—癸内酯的合成研究

报道了用环戊酮与戊醛经缩合，脱水，加氢及Baeyer-Villiger氧化反应合成δ－癸内酯的方法，总产率为51．36％。     

MiR-205 inhibits the invasion and migration of esophageal squamous cell carcinoma by modulating SMAD1 expression

Esophageal squamous cell carcinoma （ESCC） is one of the most lethal cancers worldwide. In this study, we aimed to investigate the underlying mechanisms of metastasis inhibition by miR-205 in ESCC. In microRNA （miRNA） array and quantitative RT-PCR analyses, we found that the expression level of miR-205 was significantly lower in patients with lymph node metastasis compared with that in patients without lymph node metastasis. After transfection of miR-205 mimics or inhibitors into ESCC cell lines, a significant negative correlation was observed between the expression level of miR-205 and Smad 1. In luciferase reporter assays, we revealed that miR- 205 inhibited the expression of SMAD1 by targeting the 3＇ untranslated region （3＇-UTR） of SMAD1 mRNA in ESCC cells. Furthermore, our results showed that miR-205 sup- pressed the invasion and migration of ESCC cells, whereas Smadl increased their invasion and migration. Taken together, our study demonstrates that miR-205 functions as a suppressor of tumor metastasis by regulating SMAD1 expression through targeting the 3＇-UTR of SMAD1 mRNAin ESCC. Therefore, miR-205 may be a potential therapeutic target for miRNA-based therapy of ESCC.     

导学有利于教学的基本价值实现

文章阐述了导学要因势利导,要引导学生的主体意识觉醒,明确学习目的,引导提高能力,引导学会学习的方法,引导优良品格的培养.     

A new texture analysis approach

A new texture analysis approach by using Gibbs random field model is discussed. A parameter vector is defined in order to compute potentials of textures. It is found that texture features can be provided by its corresponding parameter vector, and the vector can be estimated in terms of maximum potential. Conclusions can be inferred that this new method based on the maximum potential is valid. Supported by the National Natural Science Foundation of China Zhang Zhan: born in 1971, Ph. D. graduate student     

HT30-54灰铸铁激光表面淬火研究

本文研究了不同涂层条件下,对HT30-54灰铸铁进行激光处理的工艺参数与硬化层深度的关系,以及工艺参数与显微组织和硬度的关系。结果表明,选用扫描速度7～28mm/s,输出功率450～840W时,硬化层的显微组织是针状马氏体加片状石墨,表面硬度值是HV_(0.05)800。     

人垂体嫌色性腺瘤细胞ConA受体和 RNA分布的研究

应用荧光标记的ConA和RNase结合半薄切片技术对人垂体嫌色性腺瘤细胞ConA受体和RNA的分布进行了观察。结果表明,ConA受体主要分布在腺瘤细胞的核膜上,细胞质和质膜上ConA受体较少。RNA在一些细胞中主要分布在核中,一些细胞的细胞质中也有RNA分布。总体而言RNA的合成水平较高。这些结果对于探讨垂体嫌色性腺瘤细胞的特性及病理发生具有一定的意义,同时可为临床诊断及临床检验提供一些依据。     

热（核）电厂水工设计与感潮河流热污染

本文通过工程实践,结合物理模型实验和原体观测资料分析,说明热(核)电厂水工设计对防止水体热污染具有积极主动作用.感潮河流采用取、排水口在横向及垂向具有一定位差的差位式布置.能有效地控制近区温度场和超温区.从节约投资、电厂安全运行和水资源保护等各方面比较,差位式均优于其它布置方案.     

龙山旅游资源及开发构想

本文阐述了龙山旅游资源的特点，分析了开发该区的旅游资源的条件，并就龙山风景区的开发提出了设想。