Numerical Simulation Model of Laminar Hydrogen/Air Diffusion Flame

IntroductionDiffusion flames have been widely applied inindustrial processing systems,such as large- scaleglass- melting furnaces and hazardous wasteincinerations[1] .A numerical model is veryimportant for understanding the complexinteractions between the flow and the chemicalreactions. The laminar hydrogen/air diffusionflame is chosen.Hydrogen/air flame is easier toset up under the laboratory conditions,hence thenumerical model can be verified easily by oneexperiment.Furthermore,hydrogen/air…     

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.     

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.     

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations

Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide and occurs at a relatively high frequency in China. To identify genetic susceptibility loci for ESCC, we conducted a genome-wide association study on 2,031 individuals with ESCC (cases) and 2,044 controls of Chinese descent using 666,141 autosomal SNPs. We evaluated promising associations in an additional 6,276 cases and 6,165 controls of Chinese descent from different areas of China. We identified seven susceptibility loci on chromosomes 5q11, 6p21, 10q23, 12q24 and 21q22 (ranging from P = 7.48 × 10(-12) to P = 2.44 × 10(-31)); among these loci, 5q11, 6p21 and 21q22 were newly identified. Three variants in high linkage disequilibrium on 12q24 confer their risks to ESCC in a gene-lifestyle interaction manner, with more pronounced risk enhancement seen in tobacco and alcohol users. Furthermore, the identified variants had a cumulative association with ESCC risk (P(trend) = 7.92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer.     

基于无人机航摄的地质踏勘及风险评估

工程选址前进行的地质踏勘是保证大型基建工程顺利开展的重要环节。为探索成本低、易于操作的地质踏勘技术,本文以中南地区某矿区为例,利用无人机搭载高分辨率相机以“高密度网格成像”模式获取影像,并实现研究区域的三维重建;通过点云模型生成数字高程模型后提取相关地质信息,进行潜在地质风险的初步判定。结果表明基于无人机航摄进行地质踏勘效率相较于人工有了显著提升,三维模型清晰,很好地反映了试验区域实际状态。“高密度网格成像”模式操作方便,三维模型、点云模型与数字高程模型的结合分析结果与现实吻合良好,研究结果可为地质踏勘工作提供新思路。     

黑洞引力透镜的可观测性

通过分析黑洞引力透镜现象的特征,讨论黑洞的可观测性.在像的分离角小于最小分辨角的情况下,视亮度随像的级数的增加而指数衰减.若存在角直径可分辨,且足够大质量的黑洞,在某种条件下,可产生时间延迟.这样就使运动光源产生的相邻级数的像分开,从而达到可观测的效果.     

围垦工程群对杭州湾南岸累积水动力影响分析

以杭州湾南岸为研究对象,分别建立1997年、2007年和2015年杭州湾海域二维水动力数值模型,计算并对比各年份水动力场。从高潮位、漫滩流和流速大小三个角度来分析杭州湾大范围、累积的围垦工程对杭州湾南岸的影响。结果显示,特征点高潮位均有不同程度的抬升,自西往东呈降低趋势;围垦工程导致杭州湾南岸漫滩流特性有所减弱;大部分南岸近岸海域涨、落急流速均有不同程度的降低,并且南岸近岸海域涨急流速有较为明显的累积效应。     

土体热力学本构模型的分析与验证

分析介绍了Collins提出的土体热力学模型.该模型不仅结构简单,满足热力学原理,且通过参数的不同取值,可得到包括修正剑桥模型在内的不同屈服面的形式,具有较大的适应性和灵活性.基于微细观力学原理,深入分析了模型参数的物理意义,并导出了模型的应力应变关系.编制了该模型的点积分程序,选用具有强减缩特性的淤泥质软黏土的偏压固结不排水三轴试验结果,通过对试验结果的模拟,验证了模型的适应性与有效性.     

复合材料固化过程中温度及应变场分布的解析解

针对复合材料层合板结构件的制造工艺过程,建立简化的一维层合板结构件的瞬态热传导方程;基于典型的固化工艺曲线,推导出复合材料层合板结构件固化过程中的温度场分布函数,并建立固化过程中的过余温度和Biot数以及Fourier数的关系;绘制出层合板结构件厚度方向在典型固化工艺方案下中心线上过余温度场的分布图,然后基于温度场分布计算出层合板结构件在固化过程中导致的内部应变场分布。研究表明:在升(降)阶段,中心温度和边界温度相差不大;在保温阶段,结构件内部温度出现显著的滞后现象。     

电信BSS系统中间件MQ调优研究

电信业务支撑系统的企业应用集成平台运用的是MQ等技术,但现在MQ技术存在着池容量的限制和实时性问题,影响了电信业务的正常进展．本文设计了一种新的处理方案来解决这类问题,该方案是通过数据库优先级调度算法把MQ的队列下到海量的数据库中,在数据中进行模式的优先级排列和权重处理,从而解决了业务处理的延迟问题,提高了业务处理效率．