Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

A combined genome-wide association and linkage study was used to identify loci causing variation in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10(-8)) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The association replicated in p.Phe508del homozygotes (P = 0.006) from a separate family based study (n = 557), with P = 1.49 × 10(-9) for the three-study joint meta-analysis. Linkage analysis of 486 sibling pairs from the family based study identified a significant quantitative trait locus on chromosome 20q13.2 (log(10) odds = 5.03). Our findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.     

1961-2014年西安市秋淋气候特征分析

利用1961-2014年8-10月西安市7个气象站逐日降水资料,采用降水强度指数分析了西安市秋淋天气气候变化特征.结果表明,20世纪90年代是近50年来西安市秋季9~10月降水量最少的阶段.1961年以来西安市共有23 a出现秋淋多雨时段,20世纪60年代至80年代中期较多,1983年和1984年出现强秋淋;20世纪80年代中期至21世纪10年代初期,只有1992年出现了1次秋淋天气;2011年以来,秋淋呈明显上升、增强趋势.1961-2014年秋淋天气过程平均降水量呈上升趋势,偏多年份主要出现在20世纪80年代初中期和21世纪.厄尔尼诺使秋季9~10月降水量减少,与秋淋天气存在明显的负相关关系.近54年西安市秋淋没有发生显著的气候突变,存在4~6 a、10 a和24 a左右的长振荡周期.     

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

Toll-like receptors (TLRs) act as sensors of microbial components and elicit innate immune responses. All TLR signaling pathways activate the nuclear factor-kappaB (NF-κB), which controls the expression of inflammatory cytokine genes. Transforming growth factor-β-activated kinase 1 (TAK1) is a serine/threonine protein kinase that is critically involved in the activation of NF-κB by tumor necrosis factor (TNFα), interleukin-1β (IL-1β) and TLR ligands. In this study, we identified a novel protein, WD40 domain repeat protein 34 (WDR34) as a TAK1-interacting protein in yeast two-hybrid screens. WDR34 interacted with TAK1, TAK1-binding protein 2 (TAB2), TAK1-binding protein 3 (TAB3) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in overexpression and under physiological conditions. Overexpression of WDR34 inhibited IL-1β-, polyI:C- and lipopolysaccharide (LPS)-induced but not TNFα-induced NF-κB activation, whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-κB activation by these ligands. Our findings suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway. D. Gao and R. Wang contributed equally to this work.     

Ti-1300钛合金挤压管材组织性能研究

通过室温拉伸测试和显微组织观察,研究了挤压温度和热处理工艺对Ti-1300钛合金挤压管材显微组织和力学性能的影响,讨论了热加工工艺、显微组织和力学性能之间的关系。结果表明：Ti-1300钛合金在两相区挤压后的横向组织均匀细小,纵向组织沿挤压加工流线破碎均匀;其拉伸强度高达1 445 MPa。管材在相变点以上的高温固溶组织主要由等轴β相晶粒组成,具有较好的塑性。合金两相区挤压后具有较好的强度和塑性的匹配,两相区挤压的塑性明显优于β单相区挤压,尤其面缩。试样经过固溶时效处理后显微组织明显细化,强度大幅度提高,可达1 300 MPa以上。     

我国湿地保护立法研究

湿地被称为“地球之肾”，是地球三大生态系统之一，在促进生态文明建设、构建和谐社会中具有重要作用．然而，近年来我国湿地破坏严重，其原因主要是我国湿地保护法律制度的不健全．我国湿地保护立法缺少中央立法、湿地内涵与外延不明确等，应借鉴发达国家经验提出相关完善建议．     

汾河流域降水量及蒸发量的空间变异性分析研究

借助于地质统计学方法对汾河流域的多年平均降雨量和蒸发量的空间变异性进行了分析,揭示了多年平均降水量和蒸发量的空间变异特征,并应用Kriging方法进行空间插值.分析结果表明,汾河流域多年平均降水量和蒸发量在不同的分割距离范围内有不同的空间相关性,多年平均降水量具有比较明显的地带性,蒸发量分布变化地带性不强.     

我的管理策略

本文介绍了校长的管理策略,采取的沟通法宝是"校长的短信经".充分挖掘教师的潜能和才智.最大限度地调动其教学的积极性.     

Removable ears of 1-extendable graphs

<正> Carvalho,Lucchesi and Murty proved that any 1-extendable graph G different from K_2and C_(2n)has at least Δ(G)edge-disjoint removable ears,and any brick G distinct from K_4 and■hasat least Δ(G)-2 removable edges,where Δ(G)denotes the maximum degree of G.In this paper,weimprove the lower bounds for numbers of removable ears and removable edges of 1-extendable graphs.It is proved that any 1-extendable graph G different from K_2 and C_(2n)has at least χ′(G)edge-disjointremovable ears,and any brick G distinct from K_4 and■has at least χ′(G)-2 removable edges,whereχ′(G)denotes the edge-chromatic number of G.     

花岗岩型铀矿床的三种成矿模式及其找矿意义

花岗岩型铀矿床的成因是多种多样的,作者认为可用“演化成矿”,“活化成矿”及“演化和活化混合成矿”三种成因模式概括华南花岗岩型铀矿床的成矿过程.对三种模式的成矿机理及找矿意义的研究表明,与不同成因系列产铀花岗岩有关的铀矿床成因专属性存在着差别.与改造型产铀花岗岩有关的铀矿床成因类型较多,上述三种成因模式均可见到,而与同熔型产铀花岗岩有关的铀矿床则以“演化成矿”为主.属不同成矿模式的铀矿床其铀富集机理和成矿过程也不尽相同,故其找矿判别标志也有所差异.