不同发展模式下的建设用地需求量预测模型研究——以和龙市为例

以和龙市1996-2005年国内生产总值、人口总量以及建设用地总量的数据为基础,并将周围同级地区的发展情况作为影响因素纳入预测模型中,基于不同的出发点对其未来的发展拟定了3种不同的发展模式.根据所选取的参照物的指标不同,分别运用时间序列模型对和龙市2020年的建设用地量进行模拟预测.通过比较假定的3种发展模式下建设用地...     

黄芩苷固体脂质纳米粒的制备及大鼠在体肠吸收研究

选用硬脂酸、单硬脂酸甘油酯混合脂质作为载体,以卵磷脂作为乳化剂制备黄芩苷固体脂质纳米粒(BC-SLN),并考察其大鼠在体肠吸收特性.采用热匀质法(hot homogenization technique,HHT)制备BC-SLN,采用循环灌注技术评价黄芩苷固体脂质纳米粒和黄芩苷溶液大鼠在体肠吸收特性.制得的BC-SLN平均粒径为(150.8±47.2)nm,zeta电位为(-39.85±0.86) mV,载药量为(4.86±0.37)%,包封率为(88.52±0.32)%,大鼠在体肠吸收实验表明,BC-SLN与黄芩苷溶液相比,吸收速率常数Ka和每小时吸收百分率p均呈增加趋势,有显著性差异(P＜0.05),黄芩苷固体脂质纳米粒能够促进黄芩苷大鼠肠吸收.     

氧化锌矿物浸出渣中铅、锶的提取及动力学分析

NH₄HCO₃ conversion followed by HCl leaching was performed and proven to be effective in extracting Pb and Sr from zinc extracted residual. The mechanism and operating conditions of NH₄HCO₃ conversion, including molar ratio of NH₄HCO₃ to zinc extracted residual, NH₄HCO₃ concentration, conversion temperature, conversion time, and stirring velocity, were discussed, and operating conditions were optimized by the orthogonal test. Experimental results indicate that NH₄HCO₃ conversion at temperatures ranging from 25 to 85°C follows the shrinking unreacted core model and is controlled by inner diffusion through the product layer. The extraction ratios of Pb and Sr under optimized conditions reached 85.15% and 87.08%, respectively. Moreover, the apparent activation energies of Pb and Sr were 13.85 and 13.67 kJ·mol?1, respectively.     

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7, which encodes a tumour-suppressor protein, is frequently found in various types of human cancer, including breast cancer, colon cancer and T-cell acute lymphoblastic leukaemia (T-ALL). In line with these genomic data, engineered deletion of Fbw7 in mouse T cells results in T-ALL, validating FBW7 as a T-ALL tumour suppressor. Determining the precise molecular mechanisms by which FBW7 exerts antitumour activity is an area of intensive investigation. These mechanisms are thought to relate in part to FBW7-mediated destruction of key proteins relevant to cancer, including Jun, Myc, cyclin E and notch 1 (ref. 9), all of which have oncoprotein activity and are overexpressed in various human cancers, including leukaemia. In addition to accelerating cell growth, overexpression of Jun, Myc or notch 1 can also induce programmed cell death. Thus, considerable uncertainty surrounds how FBW7-deficient cells evade cell death in the setting of upregulated Jun, Myc and/or notch 1. Here we show that the E3 ubiquitin ligase SCF(FBW7) (a SKP1-cullin-1-F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting MCL1, a pro-survival BCL2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3. Human T-ALL cell lines showed a close relationship between FBW7 loss and MCL1 overexpression. Correspondingly, T-ALL cell lines with defective FBW7 are particularly sensitive to the multi-kinase inhibitor sorafenib but resistant to the BCL2 antagonist ABT-737. On the genetic level, FBW7 reconstitution or MCL1 depletion restores sensitivity to ABT-737, establishing MCL1 as a therapeutically relevant bypass survival mechanism that enables FBW7-deficient cells to evade apoptosis. Therefore, our work provides insight into the molecular mechanism of direct tumour suppression by FBW7 and has implications for the targeted treatment of patients with FBW7-deficient T-ALL.     

On-orbit target tracking and inspection by satellite formation

A new type of estimator is developed for the satellite formation to track and inspect on-orbit targets. The follower satellite in the formation works without relative sensors, and its target pointing commands are derived based on relative orbital dynamics. The centralized estimator based on truth measurement is designed, however, this estimator is proved unstable because of the lack of necessary measurement information. After that, an alternative estimator based on pseudo measurement is designed, and its observability and controllability are analyzed to qualitatively evaluate the convergence performance. Finally, an on-orbit target inspection scenario is numerically simulated to verify the performance of the estimator based on pseudo measurement.     

数量测定方法在商品价格分析中的应用

主要阐述应用偏态、峰度和弹性３种数量测定方法分析市场商品价格偏离其价值的方向、程度和市场商品价格的集中趋势，并给出相应的数学模型。     

硅石代水晶原料制备工艺初探

分析了用硅石作原料生产透明石英玻璃的必要性和可能性，研究出了一整套行之有效的硅石原料的制备工艺，对开发新的石英玻璃原料资源具有重要的现实意义     

能源需求预测的区域类比法研究：以湖南省为例

本文提出了区域类比法预测未来省域能源需求量的研究思路，在运用区域类比法的基础上结合运用弹性数法，部门分析法，人均能耗法对湖南２０００年，２０２０年，２０５０年所需能源量进行预测，可以提高预测质量，其预测的结果可供政府部门拟定国民经济战略规划时参考。／     

番茄酱生产中HACCP系统的应用

本文运用ＨＡＣＣＰ管理系统，在番茄酱生产过程中对可能产生食品污染的各种危害因素进行分析，确定关键控制点，制订出相应的预防控制措施，保证产品质量及卫生安全，以提高产品的出口合格率。     

核电压力壳材料SA508－1a钢断裂韧性K_（IC）的可靠性研究

本文对核电压力壳材料ＳＡ５０８－１ａ钢断裂韧性ｋＩＣ的Ｗｅｉｂｕｌｌ分布及对数正态分布的参数给出了四种不同的估计方法，并通过кодмогров检验和极大拟然比进行优选，确定该材料ＫＩＣ的概率分布．最后求出该ＫＩＣ转变曲线９５％、９９％可靠性的分布带，为该材料的可靠性研究提供了理论依据和实际参数．