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141.
A second generation human haplotype map of over 3.1 million SNPs 总被引:2,自引:0,他引:2
International HapMap Consortium Frazer KA Ballinger DG Cox DR Hinds DA Stuve LL Gibbs RA Belmont JW Boudreau A Hardenbol P Leal SM Pasternak S Wheeler DA Willis TD Yu F Yang H Zeng C Gao Y Hu H Hu W Li C Lin W Liu S Pan H Tang X Wang J Wang W Yu J Zhang B Zhang Q Zhao H Zhao H Zhou J Gabriel SB Barry R Blumenstiel B Camargo A Defelice M Faggart M Goyette M Gupta S Moore J Nguyen H Onofrio RC Parkin M Roy J Stahl E Winchester E Ziaugra L Altshuler D Shen Y Yao Z Huang W Chu X He Y Jin L Liu Y 《Nature》2007,449(7164):851-861
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between 0.9 and 0.96 depending on population. We demonstrate that the current generation of commercial genome-wide genotyping products captures common Phase II SNPs with an average maximum r2 of up to 0.8 in African and up to 0.95 in non-African populations, and that potential gains in power in association studies can be obtained through imputation. These data also reveal novel aspects of the structure of linkage disequilibrium. We show that 10-30% of pairs of individuals within a population share at least one region of extended genetic identity arising from recent ancestry and that up to 1% of all common variants are untaggable, primarily because they lie within recombination hotspots. We show that recombination rates vary systematically around genes and between genes of different function. Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations. 相似文献
142.
Genome-wide detection and characterization of positive selection in human populations 总被引:3,自引:0,他引:3
Sabeti PC Varilly P Fry B Lohmueller J Hostetter E Cotsapas C Xie X Byrne EH McCarroll SA Gaudet R Schaffner SF Lander ES;International HapMap Consortium Frazer KA Ballinger DG Cox DR Hinds DA Stuve LL Gibbs RA Belmont JW Boudreau A Hardenbol P Leal SM Pasternak S Wheeler DA Willis TD Yu F Yang H Zeng C Gao Y Hu H Hu W Li C Lin W Liu S Pan H Tang X Wang J Wang W Yu J Zhang B Zhang Q Zhao H Zhao H Zhou J Gabriel SB Barry R Blumenstiel B Camargo A Defelice M Faggart M Goyette M Gupta S Moore J 《Nature》2007,449(7164):913-918
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia. 相似文献
143.
应用生物膜填料塔对工业废气中常见的甲苯、苯乙烯、甲醛、CS2,SO2,H2S,NOx等7种气态污染
物进行净化实验,结果表明,采用专用菌种挂膜制作的生物膜填料塔对该7种气态污染物均有生物净化作用,
但其对SO2,H2S,NOx等3种无机污染物的生物净化作用(生化去除量可达90~150mg桙L·h)明显优于对甲苯、
苯乙烯、甲醛、二硫化碳等4种有机污染物的净化作用(生化去除量除对甲苯的可达100mg桙L·h外,均低于30
mg桙L·h)。研究确定了净化各污染物的适宜操作条件,并对7个专用菌种进行了鉴定。 相似文献
144.
针对传统隔振方法对低频振动无法取得较好效果的问题,分析了波阻块( WIB)和蜂窝形波阻块( HWIB)对高速铁路引发的低频振动的隔振效果.首先建立了列车-路基的数值计算模型,将列车荷载简化为沿路基向前的移动荷载列,并采用基于拉格朗日算法的有限差分软件计算了埋设WIB和HWIB前后场地土的振动情况,最后与空沟的隔振效果进... 相似文献
145.
提出了一种基于音频特征和逼近信号统计特征的零水印算法.实验结果表明,该算法能根据音频自身的特点寻找到适合用于嵌入水印的音频帧,实现水印信息的嵌入、提取和盲检测,在不改变听觉质量的同时降低了计算量,提高了水印的鲁棒性. 相似文献
146.
城市绿化主要是在生态效益的基础上实现美化功能,使城市环境质量得到改善,使自然破坏得到缓解,促进社会经济与环境的可持续发展.文章结合珠海莱菌半岛小区园林景观工程,对园林绿化施工管理进行了论述. 相似文献
147.
文章针对目前工程建设领域招标投标活动中招标代理机构市场行为、评标专家评标活动和评标方法存在的问题,提出了加强工程建设领域招标投标活动管理的方法. 相似文献
148.
149.
要建造一个高质量、高标准的建筑产品,除了好的建筑设计外,施工质量是不可忽视的重点,若是把设计比喻成建筑产品的灵魂,那么工程质量就是延续灵魂的保障。因此要将建筑施工质量管理放在首位,文章分析了建筑施工前期与施工中期的质量控制要点。 相似文献
150.
Isothermal fatigue (IF) tests were performed on H13 tool steel subjected to three different mechanical strain amplitudes at a constant temperature to determine the effects of mechanical strain amplitude on the microstructure of the steel samples. The samples' extent of damage after IF tests was compared by observation of their cracks and calculation of their damage parameters. Optical microscopy (OM) and scanning electron microscopy (SEM) were used to observe the microstructure of the samples. Cracks were observed to initiate at the surface because the strains and stresses there were the largest during thermal cycling. Mechanical strain accelerated the damage and softening of the steel. A larger mechanical strain caused greater deformation of the steel, which made the precipitated carbides easier to gather and grow along the deformation direction, possibly resulting in softening of the material or the initiation of cracks. 相似文献