Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in approximately 3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.     

Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating

Cilia beating is powered by the inner and outer dynein arms (IDAs and ODAs). These multi-subunit macrocomplexes are arranged in two rows on each outer doublet along the entire cilium length, except its distal end. To generate cilia beating, the activity of ODAs and IDAs must be strictly regulated locally by interactions with the dynein arm-associated structures within each ciliary unit and coordinated globally in time and space between doublets and along the axoneme. Here, we provide evidence of a novel ciliary complex composed of two conserved WD-repeat proteins, Fap43p and Fap44p. This complex is adjacent to another WD-repeat protein, Fap57p, and most likely the two-headed inner dynein arm, IDA I1. Loss of either protein results in altered waveform, beat stroke and reduced swimming speed. The ciliary localization of Fap43p and Fap44p is interdependent in the ciliate Tetrahymena thermophila.     

基于DEA模型的电子商务网站综合评价与质量诊断

在网络经济时代,电子商务网站运行效率直接关系到企业的生存和发展.电子商务网站评价作为比较网站优劣、指导网站建设的重要方法和手段,受到电子商务领域学术界和企业界的共同关注.本文提出基于DEA的电子商务综合评价与质量诊断方法.该方法避免了各种指标权重确定方法的主观性和不确定性,并在评价基础上对弱DEA有效和非DEA有效商务网站进行质量诊断,指明改进和提高效率的方法与途径.实例分析证实了该方法的有效性和科学性.本文的研究丰富了电子商务评价理论,为当前电子商务网站评价提供了切实可行的技术经济分析方法.     

具有感载比例阀的轻型客车制动系统分析及实验验证

文章建立了具有感载比例阀的轻型客车制动系统分析模型,对轻型客车制动系统的制动性能、制动踏板力、制动稳定性及其前后制动力的匹配进行了详细地分析;以HFC6500A1轻型客车为例进行了理论计算和实验验证。理论计算和实验结果基本吻合,证明了所建模型的正确性。     

Sn的质量分数对Bi-Sn合金熔体结构的影响

用相对能量耗散方法在升温过程中对纯Bi、纯Sn及Bi-Sn合金熔体进行了较系统地研究。结果表明,随着Sn质量分数的不同,熔体表现出不同的相对能量耗散行为;富Sn合金熔体的相对能量耗散行为与纯Sn相似,富Bi合金熔体的相对能量耗散行为与纯Bi相似。     

基于透明代理的Linux防火墙的设计与实现

文章所设计的防火墙系统采用在Linux内核中设置访问规则,通过数据包侦听与截获模块以及访问控制管理模块,实现对内部用户的访问控制;经性能测试,可以有效地解决包过滤功能不能解决的问题,并对其关键技术进行了剖析。     

关于Gauss-Per Kai型数值积分方法

该文利用带权Gauss型数值积分的构造方法和Per Kai多项式推导出了Gauss-Per Kai求积公式,估计了截断误差,并做了一些推广。由实例说明该方法具有节点简单及精度高等优点。     

考虑断裂过程区的混凝土Ⅰ-Ⅱ复合型断裂判据研究

根据以前的混凝土Ⅰ-Ⅱ复合型断裂实验资料,同时采用数值模拟实验的方法,基于双K断裂准则,分别计算了混凝土Ⅰ-Ⅱ复合型断裂试件失稳断裂破坏时,断裂过程区影响的临界有效裂缝长度ac及应力强度因子KⅠ、KⅡ。根据分析计算结果,建立了考虑断裂过程区的新的Ⅰ-Ⅱ复合型断裂K判据,并与课题组以前的K判据作了分析比较。     

反计算机取证技术研究

分析了反计算机取证的基本概念和方法,比较了反计算机取证所采用的数据擦除、数据加密、数据隐藏、数据混淆和数据转换等主要技术,并提出了一种安全、高效的基于m序列的数据擦除方法.     

简单管水力系统水击的级数解析解

针对简单水力系统的基本方程,考虑阀门按线性关闭历时规律的初始条件和边界条件,利用该偏微分方程组的形式解,推导出时间关于系统末端水击的一阶线性微分方程,从而求解了系统末端水击的隐式解析解.进一步从数学上将水击分解成均具有级数解的两部分,利用三角级数展开的方法分别求解其级数解,最后给出了水击级数解析解的表达式.