Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

多档次概率罐子模型估计的渐近性质

对多个处理且试验结果为多档次的临床试验,构建了其概率罐子模型。研究了模型中每个处理试验结果发生的概率。利用极大似然估计方法得到其估计量,并获得此估计量具有渐近正态性。     

光谱辐射标准和计量实验站的建设和研究

介绍了光谱辐射标准和计量光束线（U27）的光学设计、结构和实验站设备，利用透射光栅和AXUV100G探测器系统研究了掠入射分支（SGM）5～140nm的高次谐波情况；给出了研究结果和不同滤片材料对高次谐波的抑制情况，Zr，Si3N4和Al滤片可以有效的抑制5～34nm的高次谐波，MgF2能有效的抑制115～140nm的高次谐波．     

应用型高技能数控人才实训模式的研究——以井冈山大学工学院为例

本文介绍了应用型高技能数控人才的培养目标,从加大设备投入、安装通用软件、保证学生实践时间、建立一支高水平师资队伍、加强校企合作这些方面着手,建立了一套较为完善的实训模式,以增强学生的编程、操作、软件应用等方面的能力。     

旋流式低温送风口的实验研究

对新研制的一种旋流式低温送风口进行了空气动力、速度场、温度场及噪声测试.测试结果表明该旋流式低温送风口诱导效果好、阻力小、能耗低、噪声低、送风均匀、不结露,完全能满足低温送风要求.     

海口市番茄反季节栽培品种比较试验初报

海口市番茄生产的正常季节是冬种春收。其产量虽然较高,但产值较低。本试验是通过引进耐热番茄品种,将播种期推迟到二月春种夏收,即反季节栽培。试种结果初步表明:泰引3号、扬帆2号等引进品种,在气温较高的条件下,植株生长正常,座果率较高,产量与品质能达到当地正常季节栽培的水平。我们初步认为,泰引3号比较理想,可在海口市郊进一步试种。     

Mechanism of Microwave Effects on Conductivity of Solution

The relation between microwave conductivity and normal conductivity of solution is compared in this thesis. By building mathematical model and theoretical analyses, it indicates that the relationship of in situ conductivity of solution in microwave field and temperature is similar to that in non-microwave field. It can be expressed by quadratic equation but the values of both conductivities are different. Microwave field has effect on the mean path δ or hot vibrational frequency v of ions in solution. In microwave field, the mean energy barrier, which ions must surmount as they transit, is the function relation to temperature.     

入世与出世--儒家文化与基督文化之比较研究

从文化背景、精神意向、人生态度、思维方式等方面，对儒家文化与基督文化进行了比较研究。并试图对这两种文化分别进行扬弃与整合。     

入世后西部地区如何抑制第二次人才快速外流

加入WTO后，跨国公司和东部企业为争夺人才竞相出台了优惠的政策，导致了西部地区继改革开放之后第二次人才快速外流。西部地区必须从政府宏观和企业微观两个层面着手，采取一系列积极有效的政策措施，来抑制人才的快速外流。