Inducing dopaminergic differentiation of expanded rat mesencephalic neural stem cells by ascorbic acid in vitro

Ascorbic acid (AA) induced differentiation of neural stem cells (NSCs) into dopaminergic (DAergic) neurons is reported.NSCs derived from rat mesencephalon were maintained and expanded in a defined medium containing mitogens of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF).Compared with the control, ascorbic acid treatment led to more DAergic neuronal differentiation as indicated by the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT), which are specific markers of dopamine neurons.AA induction also enhanced expression of Nurr1 and Shh.PD98059, an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, could block AA-induced Nurr1, TH and DAT mRNA expression.The results might suggest a new strategy to provide enough dopaminergic cells for the therapy of Parkinson's disease (PD), and Nurr1 and ERK signaling pathway might participate in the AA-induced DAergic differentiation.     

Relationship between the exposure dose of high intensity focused ultrasound and the heated necrosis element

Heated necrosis element of tissues is the basis for treating tumor by high intensity focused ultrasound (HIFU), so study on the relationship between the HIFU exposure dose and the heated necrosis element of tissues is of great significance for both HIFU clinical applications and basic research. Using Pennes and Rayleigh formulae the relationship between the exposure dose of an annular focused transducer and the heated necrosis element (I.e. Biological focused region) in a bovine liver in vitro at a depth of 2 cm is simulated in an exposure dose range with radiation sound intensity of 7000～25400 W/cm2 and exposure time of 0～20 s. The theoretical results appear to be in quite good agreement with the experimental ones. It is shown that on the basis of existing theories the heated necrosis element produced by HIFU exposure can be predicted. The deviation of the theory from the experiments under higher exposure dose has also been discussed.     

利用声誉信息的机会主义行为对合作的影响

基于声誉的间接回报是合作演化的一类重要机制,其中的个体对声誉好的个体倾向合作,但自利个体利用声誉信息的机会主义是对合作的威胁。本文建立了演化博弈模型,群体中包含回报型个体和投机型个体。对一个简化模型的分析表明,当一代中交互次数较少时,投机型个体能够入侵回报型群体。对复杂情景的计算机仿真结果表明:当采用声誉对称计算方式时,群体合作水平较低;当采用声誉非对称计算方式时,群体合作水平显著提高。说明声誉非对称计算方式能够抑制机会主义促进合作。     

基于相关矩阵对角化和遗传算法的盲源分离法

提出了一种新的基于相关矩阵对角化的代价函数作为衡量输出信号独立性的测度。为了扩大搜索空间,降低各信源之间的互相关性,将代价函数进行了非线性变换。还提出了利用实数编码的遗传算法对代价函数进行最优化搜索,以克服传统梯度搜索方法容易陷入局部收敛的缺点。此方法不仅适用于平稳或非平稳信号,而且还可用于瞬时或卷积混和模型的盲源分离问题。仿真实验表明,该算法具有快速收敛性能和高精确度等优点,能够大大提高分离后的输出信噪比。     

基于聚类和粗糙集的智能邮件过滤系统研究

粗糙集理论是一种新的处理不精确、不完全与不相客知识的数学工具，随着Internet的发展，以及电子邮件的广泛应用，将有大量的邮件以待阅读和处理，介绍了一种基于聚类和粗糙集对邮件进行过滤的系统，实战证明，这是一种可行有效的过滤方法。     

工序控制方法中工序的诊断调节及技术经济分析

在工序控制中常因异常而出现不良品,通过对样本观测值的分析,可尽快地发现工序异常,寻求原因,并使工序迅速恢复正常状态.这种控制方法是维持工序稳定,使工序能力处于较为理想状态,使产品质量特性不偏离中心的一种有效方法.     

一种有效的基于实数编码的多目标遗传算法

针对实数编码遗传算法提出了一种通用的基于决策变量的复合交叉算子,并将之用于多目标优化问题的求解,算法效果良好,一定程度上解决了高维多目标优化问题在用遗传算法求解时收敛性差这一难题.通过实验首次揭示了交叉点数对多目标遗传算法性能的影响.     

废墟中的眺望——《男人的一半是女人》寓言批评

"寓言"理论是西方马克思主义美学家本雅明的一个重要思想范畴,它立足于对17世纪德国悲悼剧形式的深刻体察,借助"寓言"这一文体概念提出了与传统"象征"体系相对应的历史观和文学观."寓言"理论对现代主义文学的阐释具有重大价值,它更关注个人命运与日常感受,以个人的"体验"取代了整体性的历史"经验",力图发掘出文学作品中碎片式、废墟式的历史景观,从而具备了穿透主流意识形态的强大的批判力.以"寓言"理论观照中国20世纪80年代文学主流转型期的重要文本--张贤亮的<男人的一半是女人>是一次危险的解构之旅,它将为我们重新认识张贤亮及"反思文学"中的异质提供一个崭新的维度.     

MINIMAL INVERSION AND ITS ALGORITHMS OF DISCRETE-TIME NONLINEAR SYSTEMS

The left-inverse system with minimal order and its algorithms of discrete-time nonlinear systems are studied in a linear algebraic framework. The general structure of left-inverse system is described and computed in symbolic algorithm. Two algorithms are given for constructing left-inverse systems with minimal order.     

冷却方式对Mg-3Nd合金显微组织和物相构成的影响

制备了急冷和铸造的Mg-3mass%Nd合金,采用显微组织分析、X-射线物相分析、电子探针微区成分分析、硬度和强度等检测分析,研究了合金的显微组织、物相构成和力学性能.探讨了压缩变形对铸态合金组织和性能的影响.结果表明,急冷可以大幅度减小晶粒尺度及改变合金的物相构成.急冷合金的物相构成为过饱和α-Mg固溶体相;铸态样品的物相构成为α-Mg固溶体和Mg41Nd5.实验还表明,铸态样品压缩变形后产生大量的形变孪晶,提高了合金的强度.