Pathways for oxidative fuel provision to working muscles: Ecological consequences of maximal supply limitations

The study of metabolic fuel provision and its regulation has reached an exciting stage where specific molecular events can be correlated with parameters of the organism's ecology. This paper examines substrate supply pathways from storage sites to locomotory muscle mitochondria and discusses ecological implications of the limits for maximal flux through these pathways. The relative importance of the different oxidative fuels is shown to depend on aerobic capacity. Very aerobic, endurance-adapted animals such as long distance migrants favor the use of lipids and intramuscular fuels over carbohydrates and circulatory fuels. The hypothesis of functional co-adaptation between oxygen and metabolic fuel supply systems allows us to predict that the capacity of several biochemical processes should be scaled with maximal oxygen consumption. Key enzymes, transmembrane transporter proteins, glucose precursor supply and soluble fatty acid transport proteins must all be geared to support higher maximal glucose and fatty acid fluxes in aerobic than in sedentary species.     

基于自适应共轭梯度算法的高分辨率谱估计器

基于AR模型的功率谱估计是现代谱估计应用非常广泛的一种方法。通过对一全极点模型的参数估计来实现功率谱估计。提出了一种采用自适应共轭梯度算法来进行参数估计的方法。由于共轭梯度算法采用迭代运算求解Yule-Walker方程,同现有的谱估计算法相比,大大减小了谱估计算法的计算复杂度;随着自相关矩阵阶数的增大,该方法谱估计精度在小信噪比下提高显著。仿真结果表明,这种方法和基于AR模型的其它谱估计方法在不同信噪比下具有几乎相同的分辨率。因此,该谱估计算法具有重要的实用意义,有助于谱估计算法的实时实现。     

适应市场经济规律,实行集中采购

本文从集中采购这一概念入手,提出了高校仪器、设备招标工作的基本程序及实行集中采购的一些具体做法,供大家参考.     

改革开放以来我国思想解放划分标准研究

二十多年来我国改革开放和社会主义建设的历程,就是思想解放的历程。改革开放以来,我们党和国家先后 经历多次思想解放运动,由于选择的判断标准不同,得出的思想解放的具体次数是不一样的。根据已总结出来的七个 不同标准,可以得出“二次”、“三次”、“四次”和“五次”解放思想的结论。     

特殊气候条件下水泥混凝土路面施工质量控制

从雨季施工，高温季节和低温季节施工以及施工质量检测等方面，论述了水泥混凝土路面在特殊气候条件下的施工质量控制方法及应注意的事项。     

Game Theory Study on Distributors＇ Alliance to Gain Competitive Advantage in Marketing Channel

Using the Cournot Game Model, this paper has analyzed the motivation of the distributors＇ alliance to gain competitive advantage in marketing channel. At first, this paper separately analyzed the advantage of alliance in the situation of one- short game and infinitely repeated game, then, based on the analysis of distributors＇ betrayal of the alliance under infinitely repeated game, the conditions to maintain the distributors alliance are put forward and discussed.     

Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.

The inherited osteolyses or 'vanishing bone' syndromes are a group of rare disorders of unknown etiology characterized by destruction and resorption of affected bones. The multicentric osteolyses are notable for interphalangeal joint erosions that mimic severe juvenile rheumatoid arthritis (OMIMs 166300, 259600, 259610 and 277950). We recently described an autosomal recessive form of multicentric osteolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies in a number of consanguineous Saudi Arabian families. We localized the disease gene to 16q12-21 by using members of these families for a genome-wide search for homozygous-by-descent microsatellite markers. Haplotype analysis narrowed the critical region to a 1.2-cM region that spans the gene encoding MMP-2 (gelatinase A, collagenase type IV; (ref. 3). We detected no MMP2 enzymatic activity in the serum or fibroblasts of affected family members. We identified two family-specific homoallelic MMP2 mutations: R101H and Y244X. The nonsense mutation effects a deletion of the substrate-binding and catalytic sites and the fibronectin type II-like and hemopexin/TIMP2 binding domains. Based on molecular modeling, the missense mutation disrupts hydrogen bond formation within the highly conserved prodomain adjacent to the catalytic zinc ion.     

提高学生科技能力,培养信息技术创新人才

培养计算机与电子信息技术的创新人才是信息产业发展的需要．本文介绍我们在培养学生的创新精神 和科技能力,提高学生分析问题和实际解决问题能力等方面的一些思考和具体的做法．     

建立我国海外投资保险制度的几点思考

从我国海外投资发展的现状、国际上可资借鉴的两种海外投资保险立法模式以及建立我国海外投资保险制度的具体立法设想几方面论述建立我国海外投资保险的相关问题.     

氯离子诱导的镍在硝酸溶液中的电流振荡

报道了氯了子诱导的镍在0．5mol.dm^-2硝酸溶液中活化－钝化过渡区电流振荡，在恒电位条件下，随着氯离子浓度的升高或者电极电位的降低，电流振荡由周期性振荡逐渐向非周期性振荡转变，根据实验结果，对该体系的电流振荡机理进行了讨论。