Genetic determinants of hair, eye and skin pigmentation in Europeans

Hair, skin and eye colors are highly heritable and visible traits in humans. We carried out a genome-wide association scan for variants associated with hair and eye pigmentation, skin sensitivity to sun and freckling among 2,986 Icelanders. We then tested the most closely associated SNPs from six regions--four not previously implicated in the normal variation of human pigmentation--and replicated their association in a second sample of 2,718 Icelanders and a sample of 1,214 Dutch. The SNPs from all six regions met the criteria for genome-wide significance. A variant in SLC24A4 is associated with eye and hair color, a variant near KITLG is associated with hair color, two coding variants in TYR are associated with eye color and freckles, and a variant on 6p25.3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R.     

圆弧曲线的二次NURBS表示方法研究

由于用NURBS曲线表示圆弧时,因圆弧圆心角不同,圆弧方向不同,难于找到圆弧NURBS通用算法,以满足控制顶点少、紧凑凸包、良好参数化等特点,因此从二次NURBS曲线插入节点算法入手,提出一种基于等分圆心角的二次NURBS曲线表示方法。     

Investigation of the effects of MoO_3 buffer layer on charge carrier injection and extraction by capacitance–voltage measurement

The effects of MoO3thin buffer layer on charge carrier injection and extraction in inverted configuration ITO/ZnO/MEH-PPV(poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene))/MoO3(0,5 nm)/Ag hybrid solar cells are investigated by capacitance–voltage measurement under dark and light illumination conditions.The efficiency of charge carrier injection and extraction is enhanced by inserting 5 nm MoO3thin layer,resulting in better device performances.Charge carrier transport of the whole device is improved and the interface energy barrier is reduced by inserting 5 nm MoO3thin buffer layer.The device fill factor is increased from 54.1%to 57.5%after modifying 5 nm MoO3.Simulations and experimental results consistently show that in the forward voltage under dark,the device with the 5 nm MoO3thin layer modification generates larger value of capacitance than the device without MoO3layer.While under illumination,the device with the 5 nm MoO3layer generates smaller value of capacitance than the device without the 5 nm MoO3layer in the bias region of reverse and before the peak position of maximum capacitance(VCmax).The underlying mechanism of the MoO3anode buffer layer on device current density–voltage characteristics is discussed.     

公共文化服务体系建构中的地方文献管理

建立公共文化服务体系是全面贯彻落实科学发展观,建设小康社会,构建社会主义和谐社会的必然要求．地方文献是图书馆服务与区域居民紧密结合的桥梁,是公共文化服务体系中的知识源泉．地方文献在公共文化服务体系构建中起到了弘扬民族优秀文化,促进社会和谐发展;维护信息公平,保障公民文化权益;缓解社会矛盾,提高社会凝聚力;缩小社会差距,弥补数字鸿沟等作用．为此,管理好地方文献资源就显得尤其重要．     

折板除沫器流场与分离效率的数值模拟

选取颗粒输运多相流模型和RNGk-ε湍流模型,运用ANSYS12．1软件的CFX模块对折板式除沫器内部气液两相流场及分离效率进行了数值模拟．通过数值模拟所得液滴的运动轨迹、速度、压力和漩涡分布来深入分析内部流场情况,为优化除沫器结构设计,改进其力学性能提供理论基础．数值模拟计算结果表明,在不同液滴直径下除沫效率随转折角、级数、折板间距和气流速度都有一定的变化规律．该计算结果与已有理论计算及实验结果保持一致,对进一步修正完善理论计算和工业设计具有指导意义．     

A reconstruction method of porous media integrating soft data with hard data

The three-dimensional reconstruction of porous media is of great significance to the research of mechanisms of fluid flow. The real three-dimensional structural data of porous media are helpful to describe the irregular topologic structures in porous media. The reconstruction of porous media will be inaccurate while only hard data or no conditional data are available. Reconstructed results can be more accurate, using soft data during reconstruction. Integrating soft data with hard data, a method based on multiple-point geostatistics （MPS） is proposed to reconstruct three-dimensional structures of porous media. The variogram curves and permeability, computed by lattice Boltzmann method （LBM）, of the reconstructed images and the target image obtained from real volume data were compared, showing that the structural characteristics of reconstructed porous media using both soft data and hard data as conditional data are most similar to those of real volume data.     

基于地理信息系统与综合分析法的海水淡化厂选址

随着沿海地区淡水资源日益短缺,海水淡化产业有着广阔的发展前景,海水淡化厂厂址的合理选择成为海水淡化应用研究的热点.以红石崖街区为例,通过分析海水淡化技术特点,确定了拟建海水淡化厂的淡化工艺;根据选址的空间要求,运用ArcGIS软件确定候选厂址,综合分析经济、海域水质、社会和政策因素,从候选厂址中选出最适宜建设海水淡化厂的地址.结果表明:该方法综合考虑多种因素,可直观得出海水淡化厂适宜厂址,具有一定的科学性和可操作性.     

超高能原初宇宙线成分分辨

根据羊八井AS EC 的实验条件,利用CORSIKA( 版本5 .60) 程序进行了广延大气簇射的Monte Carlo 模拟.通过分析模拟数据,提取与原初成分有关的特征量,并利用人工神经网络对模拟数据进行多参数分析,结果表明,约有85 % 的1015～1017eV 原初质子被羊八井AS EC 正确地挑选出来.     

基于变阈值量化误差分散的半调水印算法

为解决半调(二值)图中直接嵌入水印引起的图像质量下降问题,提出一种基于变阈值量化误差分散的水印算法.通过分析打印-扫描(P-S)过程对图像的影响,得出抵抗P-S过程的半调图应具有绿噪声特性的结论;在构造水印模板和量化阈值变化规则的基础上,充分利用误差分散半调过程嵌入水印.仿真结果表明:在嵌入相同数据量时,该算法较直接嵌入法有更好的水印不可感知性;当图像遭受随机涂改、裁剪、加噪、对比度降低和低通滤波攻击时,仍能够正确提取其中嵌入的水印.     

一维反铁磁的高斯模型

利用求严格解和坐标空间重正化群两种方法,研究了只考虑近邻相互作用的一维反铁磁高斯模型,发现一维反铁磁高斯系统同一维铁磁高斯系统一样,也存在有限大小温度的相变,利用傅里叶变换的方法计算出了严格的配分函数,进而求出了系统的自由能,由自由能函数的奇异点,得到了系统的临界温度．应用坐标空间重正化群和自旋重标相结合的方法求出了系统的临界温度,得到了与严格计算相同的结果．