肝龙胶囊和美洲大蠊脱脂膏对正常大鼠胆汁分泌的影响

目的:研究肝龙胶囊和美洲大蠊脱脂膏对正常大鼠胆汁分泌的影响。方法:取80只大鼠随机分组,各组均按20 m L/kg进行灌胃给药,1次/d,连续给药7 d。采用大鼠胆汁流量实验、胆汁成分分析观察受试药的利胆作用。结果:肝龙胶囊无利胆作用,对胆汁成分无影响;而美洲大蠊脱脂膏具有利胆作用,其胆汁流量与对照组比较差异有统计学意义(P<0.05),使胆汁中TBL、DBL、IBL的含量降低(P<0.05)。结论:肝龙胶囊对正常大鼠无利胆作用;美洲大蠊脱脂膏则有利胆作用。     

表面活性剂用作磁粉分散剂的研究

从实验及原理上说明了卵磷脂是优良的磁粉分散剂。提出了实验上确定卵磷脂最佳用量的方法。     

中草药萝芙木中育亨宾生物碱的TLC-FT-SERS研究

本文应用表面增强技术将薄层色谱与近红外傅立叶变换拉曼光谱联用 ,获得到了中草药萝芙木生物碱中主要有效成分育亨宾在薄层原位的傅立叶变换表面增强拉曼光谱 .研究表明 ,在薄层色谱直径约 2mm斑点原位 ,样品的FT -SERS光谱与纯固体样品的FT -Raman光谱的主要特征峰波数基本一致 ,相对强度出现一些变化 ,固体与薄层色谱原位谱图中 ,指纹区最强峰都是表征吲哚环骨架伸缩振动、波数为 15 90cm- 1 附近的峰 .育亨宾分子以吲哚环共轭体系的π电子与表面增强活性物质银晶体微粒表面相互作用引起拉曼散射的显著增强 .获得了中草药萝芙木中主要有效成分育亨宾分离与高灵敏度指纹检测可靠的新方法 .     

Excel在仪器标准曲线绘制中的应用

利用EXCEL强大的函数功能,经过一些简单设置,完全可以绘制仪器标准曲线,其方法简单、实用,有一定的推广价值。     

Regulatory control level on the mountain the old city renovation

以山西省兴县县城旧城区控规为例,探讨山区旧城更新改造的控规编制要点,通过划分合理的功能分区、配置完善的公共基础设施、建立便捷的道路交通体系、维持恢复生态系统等,重塑旧城区整体环境,使其符合居民生活需求,促进区域经济协调发展.     

Lithium isotope evidence for subduction-enriched mantle in the source of mid-ocean-ridge basalts

'Recycled' crustal materials, returned from the Earth's surface to the mantle by subduction, have long been invoked to explain compositional heterogeneity in the upper mantle. Yet increasingly, problems have been noted with this model. The debate can be definitively addressed using stable isotope ratios, which should only significantly vary in primitive, mantle-derived materials as a consequence of recycling. Here we present data showing a notable range in lithium isotope ratios in basalts from the East Pacific Rise, which correlate with traditional indices of mantle heterogeneity (for example, 143Nd/144Nd ratios). Such co-variations of stable and radiogenic isotopes in melts from a normal ridge segment provide critical evidence for the importance of recycled material in generating chemical heterogeneity in the upper mantle. Contrary to many models, however, the elevated lithium isotope ratios of the 'enriched' East Pacific Rise lavas imply that subducted ocean crust is not the agent of enrichment. Instead, we suggest that fluid-modified mantle, which is enriched during residency in a subduction zone, is mixed back into the upper mantle to cause compositional variability.     

一种多变量系统结构辨识和参数估计算法

提出一种新的多变量系统结构辨识和参数估计算法，它可同时递推辨识多变量系统 的结构指数和所有子系统的各阶模型参数，具有计算量小，计算品质好，编程简单等优 点。     

产品竞争能力评价

本文剖析了影响产品竞争能力的主要因素,建立了有49个子项目的产品竞争能力指标体系及结构模型。利用层次分析法计算出严品竞争能力综合评价指标,使生产同类产品的竞争对手之间,可以方便地进行产品竞争能力的定量对比分析。最后,给出了实例,来说明此方法的应用.     

Germline-specific dgcr8 knockout in zebrafish using a BACK approach

Zebrafish is an important model to study developmental biology and human diseases. However, an effective approach to achieve spatial and temporal gene knockout in zebrafish has not been well established. In this study, we have developed a new approach, namely bacterial artificial chromosome-rescue-based knockout (BACK), to achieve conditional gene knockout in zebrafish using the Cre/loxP system. We have successfully deleted the DiGeorge syndrome critical region gene 8 (dgcr8) in zebrafish germ line and demonstrated that the maternal-zygotic dgcr8 (MZdgcr8) embryos exhibit MZdicer-like phenotypes with morphological defects which could be rescued by miR-430, indicating that canonical microRNAs play critical role in early development. Our findings establish that Cre/loxP-mediated tissue-specific gene knockout could be achieved using this BACK strategy and that canonical microRNAs play important roles in early embryonic development in zebrafish.