试论传统药曲制醋方法的改进

在大量调查的基础上,本文运用微生物发酵原理,深入探讨了传统药曲制醋方法的优劣,提出保留传统工艺中药物参与发酵的特点,但应科学组方,并采用纯菌种制药曲,甚至不通过制药曲直接让药物参与发酵制醋。此建议能提高传统发酵工艺的科学性,降低生产成本,缩短生产周期,提高食醋的产量和质量。     

基于HMM的多维数据下扶贫对象状态预测

针对扶贫领域中贫困、脱贫和返贫状态预测不准确,影响状态变迁的关键因素难以识别的问题,从扶贫基础数据和多个行业数据中提取8个关键特征和22个观测状态,构建观察状态和隐含状态关联关系,建立扶贫对象状态预测隐马尔可夫模型(hidden markov model,HMM)。以某深度贫困县连续3年的数据为样本,进行参数训练、测试实验和结果验证,结果表明该方法对返贫、贫困和脱贫状态有较强的预测能力,误差率较低,且能准确识别出影响返贫的关键要素。该方法对指导精准扶贫工作具有非常重要的实际意义。     

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets

We present the first analysis of the human proteome with regard to interactions between proteins. We also compare the human interactome with the available interaction datasets from yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans) and fly (Drosophila melanogaster). Of >70,000 binary interactions, only 42 were common to human, worm and fly, and only 16 were common to all four datasets. An additional 36 interactions were common to fly and worm but were not observed in humans, although a coimmunoprecipitation assay showed that 9 of the interactions do occur in humans. A re-examination of the connectivity of essential genes in yeast and humans indicated that the available data do not support the presumption that the number of interaction partners can accurately predict whether a gene is essential. Finally, we found that proteins encoded by genes mutated in inherited genetic disorders are likely to interact with proteins known to cause similar disorders, suggesting the existence of disease subnetworks. The human interaction map constructed from our analysis should facilitate an integrative systems biology approach to elucidating the cellular networks that contribute to health and disease states.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

形象思维在医学英语术语命名中的应用

形象思维在医学英语术语的命名中发挥着重要的作用。借助植物、动物、自然现象、物品、古希腊罗马神话中的人物形象对医学英语术语进行命名,可以增加医学英语术语的美感、趣味性和准确性,利于理解和记忆。     

自然科学领域著名期刊简介--Science周刊

Science杂志于 1880年创刊 ,现由美国科学促进会 (TheAmericanAssociationfortheAdvancementofScience,AAAS)主办 ,是具有科学新闻和学术期刊双重特点的国际性周刊 ,也是世界上传播范围最广的科学刊物之一 ,以发表具有重要意义的原创性科研报告为主。本文旨在介绍该刊的办刊宗旨、征稿要求及评审程序 ,以期能够更好地了解Sci ence,提高投稿率和录用率 ,把我们出色的科研成果展示给世界 ;同时也能够通过阅读Science,把握最前沿的科学研究动态 ,加强我国与世界科学界的联系。     

自然科学领域著名期刊简介-Cell及其姊妹刊

Cell创刊于 1976年 ,现已成为世界自然科学研究领域最著名的期刊之一 ,并陆续发行了 8种姊妹刊 ,在各自专业领域里均占据着举足轻重的地位。Cell以发表具有重要意义的原创性科研报告为主 ,许多生命科学领域最重要的发现都发表在Cell上。本文旨在介绍该刊及其姊妹刊的办刊宗旨、征稿要求及评审程序 ,以使我国科学家能更加了解Cell系列期刊 ,提高投稿率和录用率 ,把出色的科研成果展示给世界 ;同时也能够通过阅读Cell系列期刊 ,把握世界最前沿的科学研究动向 ,加强我国与世界科学界的联系。