“EII META-MODEL” ON INTEGRATION FRAMEWORK FOR VIABLE ENTERPRISE SYSTEMS——CITY PLANNING METAPHOR BASED ON STRUCTURAL SIMILARITY

Enterprise systems must have the structure to adapt the change of business environment. Whenrebuilding enterprise system to meet the extended operational boundaries, the concept of IT cityplanning is applicable and effective. The aim of this paper is to describe the architectural approachfrom the integrated information infrastructure (In3) standpoint and to propose for applying the "CityPlanning" concept for rebuilding "inter-application spaghetti" enterprise systems. This is mainlybecause the portion of infrastructure has increased with the change of information systems fromcentralized systems to distributed and open systems. As enterprise systems have involvedheterogeneity or architectural black box in them, it may be required the integration framework(meta-architecture) as a discipline based on heterogeneity that can provide comprehensive view of theenterprise systems. This paper proposes "EII Meta-model" as the integration framework that canoptimize the overall enterprise systems from the IT city pl     

Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains

Specific sorting signals direct transmembrane proteins to the compartments of the endosomal-lysosomal system. Acidic-cluster-dileucine signals present within the cytoplasmic tails of sorting receptors, such as the cation-independent and cation-dependent mannose-6-phosphate receptors, are recognized by the GGA (Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding) proteins. The VHS (Vps27p, Hrs and STAM) domains of the GGA proteins are responsible for the highly specific recognition of these acidic-cluster-dileucine signals. Here we report the structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors. The signals bind in an extended conformation to helices 6 and 8 of the VHS domain. The structures highlight an Asp residue separated by two residues from a dileucine sequence as critical recognition elements. The side chains of the Asp-X-X-Leu-Leu sequence interact with subsites consisting of one electropositive and two shallow hydrophobic pockets, respectively. The rigid spatial alignment of the three binding subsites leads to high specificity.     

A fast construction method for spatial index GBD-tree

This paper proposes a fast initial construction method of the GBD-tree. The GDB tree has proper characteristics for management of large amount of 2 or 3 dimensional data. However, the GBD-tree needs long initial construction time by originally proposed one-by-one insertion method. A fast insertion method has been proposed, but it needs large size of buffer capable to hold index information of all entries. The paper proposes another fast initial construction method. The method requires only limited size of work space (buffer). The experimental results show the initial construction time reduces into a third or a quarter of the one-by-one insertion method. The memory efficiency and retrieval efficiency are also improved than the one-by-one insertion method.     

“EII META—MODEL” ON INTEGRATION FRAMEWORK FOR VIABLE ENTERPRISE SYSTEMS——CITY PLANNING METAPHOR BASED ON STRUCTURAL SIMILARITY

Enterprise systems must have the structure to adapt the change of business environment.When rebuilding enterprise system to meet the extended operational boundaries,the concept of IT city planning is applicable and effective.The aim of this paper is to describe the architectural approach from the integrated imformation infrastructure(In3) standpoint and to propose for applying the “City Planning” concept for rebuilding “inter-application spaghetti” enterprise systems.This is mainly because the portion of infrastructure has increased with the change of information systems from centralized systems to distributed and open systems.As enterprise systems have involved heterogeneity or architectural black box in them,it may be required the integration framework (meta-architecture)as a discipline based on heterogeneity that can provide comprehensive view of the enterprise systems.This paper proposes “EII Meta-model” as the integration framework that can optimize the overall enterprise systems from the IT city planning point of view.EII Meta-model consists of “Integrated Information Infrastructure Map(In3-Map)”,“Service·Framework” and “IT Scenario”.It would be applicable and effective for the viable enterprise,because it has the mechanism to adapt the change.Finally,we illustrate a case of information system in an online securities company and demonstrate spplicability and effectiveness of EII Meta-model to meet their business goals.     

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest Pvalue (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.     

Chlorophyll b and phycobilins in the common ancestor of cyanobacteria and chloroplasts.

Photosynthetic organisms have a variety of accessory pigments, on which their classification has been based. Despite this variation, it is generally accepted that all chloroplasts are derived from a single cyanobacterial ancestor. How the pigment diversity has arisen is the key to revealing their evolutionary history. Prochlorophytes are prokaryotes which perform oxygenic photosynthesis using chlorophyll b, like land plants and green algae (Chlorophyta), and were proposed to be the ancestors of chlorophyte chloroplasts. However, three known prochlorophytes (Prochloron didemni, Prochlorothrix hollandica and Prochlorococcus marinus) have been shown to be not the specific ancestors of chloroplasts, but only diverged members of the cyanobacteria, which contain phycobilins but lack chlorophyll b. Consequently it has been proposed that the ability to synthesize chlorophyll b developed independently several times in prochlorophytes and in the ancestor of chlorophytes. Here we have isolated the chlorophyll b synthesis genes (chlorophyll a oxygenase) from two prochlorophytes and from major groups of chlorophytes. Phylogenetic analyses show that these genes share a common evolutionary origin. This indicates that the progenitors of oxygenic photosynthetic bacteria, including the ancestor of chloroplasts, had both chlorophyll b and phycobilins.     

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.     

A fast construction method for spatial index GBD tree 

This paper proposes a fast initial construction method of the GBDtree. The GDB tree has proper characteristics for management of large amount of 2 or 3 dimensional data. However, the GBDtree needs long initial construction time by originally proposed onebyone insertion method. A fast insertion method has been proposed, but it needs large size of buffer capable to hold index information of all entries. The paper proposes another fast initial construction method. The method requires only limited size of work space (buffer). The experimental results show the initial construction time reduces into a third or a quarter of the onebyone insertion method. The memory efficiency and retrieval efficiency are also improved than the onebyone insertion method.