Study of Treating HAPE with HBO in Situ at the Altitude of 4636 m

Study Objective ： To evaluate the treatment effect of HAPE with HBO in situ at an extreme altitude of 4636 m. To investigate the relationship between pulmonary hypertension （PH） and HAPE. To emphasize the importance of the treatment in situ. Methods： The 32 patients from the plateau of 4636 - 5130 m （the barometric pressure： 57.41 - 53.28 kPa/431.6 - 400.6 mmHg（1 mmHg = 133.3224 Pa）, the partial pressure of oxygen： 12.0 - 11.6 kPa/90.0 - 87.0 mmHg） were treated in situ of 4636 m altitude with HBO. Before and after the treatment, the clinical symptoms / signs, radiographic evidence, SaO2, and MPAP were compared. Results： The clinical symptoms/signs, and all the targets of the patients were improved dramatically （p 〈 0.001）. Conclusions： Treating HAPE with HBO is the most effective method among various therapies in situ at an extreme altitude. The pulmonary -artery pressure was significantly decreased. All eases showed improved immediately. Among the subjects, 11 eases （34.3 %） were cured at once. The therapy made it possible for patients to get further treatment at a lower altitude area with prospective good results. We suggested that treating HAPE with HBO should be the first choice in situ. There must be PH in the patients of HAPE, but the reverse is not the true. The PH is a mechanism of normal compensation of the body exposing in the hypoxie environment. It is very necessary for us to explore the threshold of PH when a HAPE happens.     

Iron metabolism in the mononuclear phagocyte system

The maintenance of body iron homeostasis requires the coordination of multiple regulatory mechanisms of iron metabolism. The mononuclear phagocyte system （MPS, composed of monocytes, macrophages, and their precursor cells） is crucial in the maintenance of iron homeostasis. Recycling of iron is carried out by specialized macrophages via engulfment of aged erythrocytes. The iron stores of macrophages depend on the levels of recovered and exported iron. However, the molecular mechanisms underlying iron homeostasis in macrophages are poorly understood. Recent studies characterizing the function and regulation of natural resistance-associated mac- rophage protein 1 （Nrampl）, divalent metal transporter 1 （DMT1）, HLA-linked hemechromatosis gene （HFE）, ferroportin 1 （FPN1）, and hepcidin are rapidly expanding our knowledge on the molecular level of MPS iron handling. These studies are deepening our under- standing about the molecular mechanism of iron homeostasis and iron-related diseases.     

影响液压支架降柱速度的原因分析

本文通过对液压支架降往过程的仿真，获得了支架液压系统的动态特性。在此基础上，分析了影响支架降柱快慢的各种因素，并探讨了提高降往速度的途径。     

阳离子淀粉CST制备及脱色性能研究

研究了在基本干的反应条件下制备阳离子淀粉的方法及其脱色性能,确定了用氢氧化钠作催化剂时的最佳反应条件。     

含氟硫A矿的水化特性

研究了含氟硫Ａ矿的水化性能及Ｆ－、ＳＯ３和Ａｌ３＋固溶量变化对Ａ矿性能的影响。研究结果表明，含氟硫Ａ矿早期水化率、液相ｐＨ值和Ｃａ（ＯＨ）２过饱和度均较大，水化产物细化，强度提高，但凝结时间较长。Ａ矿固溶Ｆ－增多．凝结时间延长；固溶Ａｌ３＋可提高水化活性；固溶ＳＯ３可缩短终凝时间。实验结果还证明，石膏可显著加快Ａ矿的早期水化。     

价夸克分布与海夸克分布的核效应

由ｌ－Ａ深度非弹性散射实验数据结合ｐ－Ａ碰撞Ｄｒｅｌｌ－Ｙａｎ截面数据来分别考察束缚核子中价夸克分布与海夸克分布的核效应，提出了一种检验解释ＥＭＣ效应的理论模型的方法。     

非匹配条件下滑动模的鲁棒性

本文研究结构系统在非匹配条件下滑动模的鲁棒性问题，首先提出了变结构系统部分不变性的概念，进而给出了变结构系统具有部分不变性的充分必要条件；最后举一个例子验证所提出的方法，本文结果解决了不确定系统在何种条件下可以直接设计出具有期望动态品质的滑动模的问题。     

癌免疫抑制机制的研究——健康人血浆对肝癌等患者细胞免疫的去抑制作用

临床上癌症患者细胞免疫功能下降的原因,多数认为是由于患者血浆中存在“免疫抑制因子”所致,也有部分认为是T淋巴细胞本身缺陷的原因。那么是不是所有的癌症患者血桨中都有这种“抑制因子”呢?我们采用E——玫瑰花结,淋巴细胞转化联合试验为细胞免疫功能的检测指标,对肝癌、肺癌、胃癌、肠癌及其他癌进行研究。发现:肝癌、肺癌及其他癌患者的血浆确有“免疫抑制因子”,因为健康人血桨对肝癌、肺癌及其他癌患者细胞免疫能起去抑制作用。也就是当患者的血桨与正常人血浆互相交换后,患者细胞免疫功能得到回升,而正常人的细胞免疫功能由于癌症患者血浆的存在而有所下降(统计学上有显著意义)。这说明癌症患者细胞免疫功能下降的原因是相当复杂的。患者血浆中的免疫抑制因子只是一方面的原因,有待于今后继续深入研究。     

利用博弈确定分配因子的财富分配模型

在传统财富分配模型中引入博弈游戏,以此确定财富分配规则,分别讨论了不含保守因子和包含保守因子情形下,系统的财富分布情况.所得结果表明,在不含保守因子时,对群体而言,系统中不同的客观影响因子对系统的财富分布趋势没有明显影响;但对个人而言,其采用的交易策略与外在的客观影响因子越接近,越有可能获取更多的财富.在包含保守因子时,个体的策略与外在客观影响因子的相近程度决定了财富分布的人员构成,但保守因子的大小很大程度上影响了财富的分布趋势,具体表现为保守因子越小,财富的分布越集中.