55CrSiA与JIS G3566—77油淬火弹簧钢丝的比较分析

在系统地对同规格的５５ＣｒＳｉＡ与ＪＩＳ Ｇ３５６６－７７油淬火钢丝的成分、组织、残留元素及力学性能进行了复查，并按相同工艺制成ＦＭ１４７发动机气阀弹簧做了比较试验后发现：该种弹簧钢丝与日本弹簧钢丝在质量上略有差距。     

石灰石类的石质保护

研制了一种可逆型的石质保护剂，涂刷在大理石、红砂石、和田玉、石灰石、青石等石质上形成保护层。经过一系列实验测试，表明该保护剂具有渗透力较强、憎水、抗酸雨等性能，可使石质耐风、雨、沙、冰冻、可溶盐、日光照射、温差变化和微生物等的侵蚀。     

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Here we show that aurora kinase A phosphorylates p53 at Ser315, leading to its ubiquitination by Mdm2 and proteolysis. p53 is not degraded in the presence of inactive aurora kinase A or ubiquitination-defective Mdm2. Destabilization of p53 by aurora kinase A is abrogated in the presence of mutant Mdm2 that is unable to bind p53 and after repression of Mdm2 by RNA interference. Silencing of aurora kinase A results in less phosphorylation of p53 at Ser315, greater stability of p53 and cell-cycle arrest at G2-M. Cells depleted of aurora kinase A are more sensitive to cisplatin-induced apoptosis, and elevated expression of aurora kinase A abolishes this response. In a sample of bladder tumors with wild-type p53, elevated expression of aurora kinase A was correlated with low p53 concentration. We conclude that aurora kinase A is a key regulatory component of the p53 pathway and that overexpression of aurora kinase A leads to increased degradation of p53, causing downregulation of checkpoint-response pathways and facilitating oncogenic transformation of cells.     

Subduction and collision processes in the Central Andes constrained by converted seismic phases

The Central Andes are the Earth's highest mountain belt formed by ocean-continent collision. Most of this uplift is thought to have occurred in the past 20 Myr, owing mainly to thickening of the continental crust, dominated by tectonic shortening. Here we use P-to-S (compressional-to-shear) converted teleseismic waves observed on several temporary networks in the Central Andes to image the deep structure associated with these tectonic processes. We find that the Moho (the Mohorovici? discontinuity--generally thought to separate crust from mantle) ranges from a depth of 75 km under the Altiplano plateau to 50 km beneath the 4-km-high Puna plateau. This relatively thin crust below such a high-elevation region indicates that thinning of the lithospheric mantle may have contributed to the uplift of the Puna plateau. We have also imaged the subducted crust of the Nazca oceanic plate down to 120 km depth, where it becomes invisible to converted teleseismic waves, probably owing to completion of the gabbro-eclogite transformation; this is direct evidence for the presence of kinetically delayed metamorphic reactions in subducting plates. Most of the intermediate-depth seismicity in the subducting plate stops at 120 km depth as well, suggesting a relation with this transformation. We see an intracrustal low-velocity zone, 10-20 km thick, below the entire Altiplano and Puna plateaux, which we interpret as a zone of continuing metamorphism and partial melting that decouples upper-crustal imbrication from lower-crustal thickening.     

论我国企业破产重整制度的完善

《中华人民共和国企业破产法》重要的创新点之一便是设立了破产重整制度,本文拟从《中华人民共和国企业破产法》对重整制度的现行规定入手,结合我国经济法制建设的要求和相关法律规则,分析其存在的立法不足,并提出相应的建议,以便使该法在司法实践中得到进一步的充实和完善,对我国新时期的经济发展发挥最大的促进作用。     

“八荣八耻”荣辱观研究综述

“八荣八耻”荣辱观提出后随即引起社会普遍关注，成为“2006年中国十大学术热点问题”之一。综观一年来的研究概况，其研究重心主要集中于“八荣八耻”荣辱观的价值和意义、深刻内涵、时代特征、建设路径和方法对策、荣辱观教育以及与传统荣辱观的关系等方面。系统梳理当下的研究现状，对“八荣八耻”荣辱观的深化研究，无疑将具有启示价值。     

TCP 数据流超时研究

Claffy于1994年基于一个小时的主干数据分析,提出了主干网数据流超时时间以64 s为宜的结论,这个结论被广泛沿用至今.在此期间互联网发生了翻天覆地的变化,这个结论是否仍然适用呢?本文以CERNET某2.5 G省网边界链路近期连续1 h报文数据构成的trace为对象,采用Claffy相似的方法进行了统计分析,得出的结论是:目前的数据流超时间隔取值16 s时就可以达到理想的效果.这个结论将对所有与网络数据流有关的工程和研究具有借鉴意义.在实验数据量方面,相对于Claffy的平均每秒1 118个报文(下文简称PPS),本次试验所采用的TRACE数据量为650 k PPS,约是前者的581倍.本文将详细介绍试验和结果产生的过程.     

数控机床现状及发展中的主要问题

简述了数控机床在中国的地位及现状，分析了数控机床发展的趋势及我国现存的主要问题。     

青藏高原开发、保护与特色经济发展

青藏高原面临的最突出的问题是生态环境恶化和牧民贫困，它放大了生态不安全、社会不安全之间的累积效应，制约着西部及国家的可持续发展。本课题的研究不论从生态安全或社会安全而言，它的意义均超出了青藏高原本身，具有全国性的重要而深远的意义。青藏高原通过实现生态系统的脆弱性和恢复能力相协调，依据自身资源优势，发展特色经济，培育新的经济增长点，从而实现区域经济的可持续发展。     

MR成像技术在脊柱压缩骨折研究中的应用

目的 探讨MR 多种成像技术对脊柱压缩骨折病因研究的价值.方法 48例(共88个椎体)脊柱椎体压缩行MR平扫T1,T2及T2脂肪抑制,DWI及T1增强扫描.其中病理性骨折28例(55个椎体,包括转移性肿瘤24例、骨髓瘤1例、结核4例);单纯性骨折20例(33个椎体,包括单纯外伤所致14例,骨质疏松6例).病理性骨折者,经穿刺检查或手术病理证实,部分临床证实;外伤或骨质疏松所致椎体压缩骨折均符合临床、实验室检查及MRI表现,部分随访证实.结果 单纯性骨折20例共33个椎体,T2WI呈高、混杂信号27个,低、等信号6个,DWI呈高、混杂信号5个,低、等信号28个.病理性骨折28例共55个椎体,T2WI呈高、混杂信号42个,低、等信号13个,DWI呈高、混杂信号51个,低、等信号4个,T1 T2组合确诊数为82.3%,多种组合T1 T2 T1增强 T2抑脂 DWI,确诊数为98.6%.结论 MR 多种成像技术联合应用对单纯性骨折和病理性骨折的鉴别可提供很大帮助.