大宁河两种小型鱼类个体和器官代谢率的比较

[目的]考察三峡库区两种小型鲤科(Cyprinidae)鱼类的个体和器官代谢率.[方法]对大宁河水域分布的红尾副鳅(Paracobitis variegatus)和云南盘鮈(Discogobio yunnanensis)的体质量、器官质量、个体代谢率和器官代谢率进行测定和比较.[结果]在校正体质量后,红尾副鳅在个体静止...     

我国证券市场混沌的判据

本文通过李雅普诺夫指数和吸引子的分数维这两个指数来研究我国证券市场的混沌特征。利用Ｗｏｌｆ提出的重构相空间技术和Ｇ－Ｐ算法分别计算了上证综指日收益率序列的李雅普诺夫指数和吸引子的分数维。从而得出我国证券市场运行于混沌状态的有力证据。     

高分辨率雷达二维图像的图像处理与特征提取

首先分析了雷达目标散射信号特征。在此基础上 ,根据MUSIC算法得到的雷达图像特点 ,通过平滑、量化、增强等适当的图像处理方式对F - 16、HY - 2 0 0 0两种飞机缩比模型在阶梯变频雷达上所获取的雷达图像进行处理 ,并形成雷达二维灰度图 ;最后 ,采用图像矩阵描述方示进行雷达图像的特征提取     

DRD1基因敲除影响雄鼠生育的分子机理研究

目的 研究DRD1基因敲除引起雄鼠生殖功能下降的机制.方法 本研究以DRD1基因敲除鼠(KO)和野生鼠(WT)为研究对象,对8周龄KO与WT雄鼠进行基因型鉴定,测体质量并计算睾丸系数,一侧睾丸HE染色观察形态,另一侧睾丸TRIzol法提取RNA,通过qRT-PCR反应,采用相对定量法,分析与生殖密切相关基因的表达差异倍...     

中国酱油发酵酱醪中嗜盐四联球菌的鉴定

从采用传统露天酿造工艺的中国酱油发酵酱醪中分离筛选嗜盐乳酸球菌,对其进行形态、生理生化特性研究及16S rDNA序列分析,在此基础上确定其分类地位,为研究其在酱油酿造中的作用奠定基础.研究结果表明,筛选菌株为四联球型,革兰氏染色阳性,不运动;接触酶反应阴性,能从葡萄糖产酸而不产气;NaC l含量为18%的培养环境下乳酸产量达2.2%;基于16S rDNA序列的系统发育分析表明筛选菌株与嗜盐四联球菌的亲缘关系最近,从而初步确定其为嗜盐四联球菌.     

一种基于标记点的近景摄影测量系统

给出了一种基于标记点的鲁棒三维重建摄影测量系统;采用编码点和非编码点等标记点方式.为了减少不同图像间误匹配的概率,采用一种新的基于编码点的匹配方法,不同图像间非编码点的匹配从编码点开始,并通过相似性准则、模糊度准则和距离误差准则来剔除误匹配,可获得非常高的正确匹配率.采用一种新的基于标记点的加权迭代特征算法,用编码点恢复相机的投影矩阵,从而可以确定相机的外部姿态参数;用非编码点恢复3D坐标.与已有的加权迭代特征算法比较,该算法避免了所有点参与计算相机的投影矩阵,运算速度更快.由于采用标记点的亚像素定位方法,提高了3D重建精度.实验结果表明,在3D重建方面,该系统是强壮和精确的.     

论公路运输枢纽层次的划分

公路运输枢纽根据其重要性和规模大小的不同有层次之分。通过对现有公路运输枢纽层次划分的分析与评价,提出了以基建规模来划分公路运输枢纽层次的标准。     

基于GIS、GPS、GSM的救护车智能管理系统研究

文章提出了一种救护车智能管理系统。该系统基于GIS、GPS、GSM技术,它能在发生紧急事故时,提供救护车到达出事地点,再从出事地点到达最近医院的最佳路径,该系统能够使救护车始终处于监控之下。我们通过设计有效的数据结构和算法来实现系统的上述功能。     

Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis

When they recognize a target cell, natural killer (NK) cells mount an attack to kill the target by exerting their cytotoxicity via the exocytosis of cytotoxic granules. Although the details of this process (which includes the movement of cytotoxic granules in the immune synapse and their fusion with the plasma membrane, releasing granzymes and perforin into the synaptic cleft) are relatively better understood, the post-exocytosis regulation of the process is still largely unknown. Here we show that a clathrin-dependent endocytosis stimulated by target cell occurs in NK92 cell line, which is closely correlated with granzyme B recovery. Inhibition of the endocytosis significantly attenuates the cytotoxicity of NK92 cells. The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.