Null controllability of some degenerate wave equations

This paper is devoted to a study of the null controllability problems for one-dimensional linear degenerate wave equations through a boundary controller. First, the well-posedness of linear degenerate wave equations is discussed. Then the null controllability of some degenerate wave equations is established, when a control acts on the non-degenerate boundary. Different from the known controllability results in the case that a control acts on the degenerate boundary, any initial value in state space is controllable in this case. Also, an explicit expression for the controllability time is given. Furthermore, a counterexample on the controllability is given for some other degenerate wave equations.     

New rapid transfer alignment method for SINS of airborne weapon systems

Transfer alignment is an effective alignment method for the strapdown inertial navigation system （SINS） of airborne weapon systems. The traditional transfer alignment methods for large misalignment angles alignment use nonlinear transfer align- ment models and incorporate nonlinear filtering. A rapid transfer alignment method with linear models and linear filtering for ar- bitrary misalignment angles is presented. Through the attitude quaternion decomposition, the purpose of transfer alignment is converted to estimate a constant quaternion. Employing special manipulations on measurement equation, velocity and attitude linear measurement equations are derived. Then the linear trans- fer alignment model for arbitrary misalignment angles is built. An adaptive Kalman filter is developed to handle modeling errors of the measurement noise statistics. Simulation results show feasibili- ty and effectiveness of the proposed method, which provides an alternative rapid transfer alignment method for airborne weapons.     

Single cell biology beyond the era of antibodies: relevance,challenges, and promises in biomedical research

Research of the past two decades has proved the relevance of single cell biology in basic research and translational medicine. Successful detection and isolation of specific subsets is the key to understand their functional heterogeneity. Antibodies are conventionally used for this purpose, but their relevance in certain contexts is limited. In this review, we discuss some of these contexts, posing bottle neck for different fields of biology including biomedical research. With the advancement of chemistry, several methods have been introduced to overcome these problems. Even though microfluidics and microraft array are newer techniques exploited for single cell biology, fluorescence-activated cell sorting (FACS) remains the gold standard technique for isolation of cells for many biomedical applications, like stem cell therapy. Here, we present a comprehensive and comparative account of some of the probes that are useful in FACS. Further, we illustrate how these techniques could be applied in biomedical research. It is postulated that intracellular molecular markers like nucleostemin (GNL3), alkaline phosphatase (ALPL) and HIRA can be used for improving the outcome of cardiac as well as bone regeneration. Another field that could utilize intracellular markers is diagnostics, and we propose the use of specific peptide nucleic acid probes (PNPs) against certain miRNAs for cancer surgical margin prediction. The newer techniques for single cell biology, based on intracellular molecules, will immensely enhance the repertoire of possible markers for the isolation of cell types useful in biomedical research.     

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.     

（1-uv）-CONSTACYCLIC CODES OVER Fp＋uFp＋vFp＋uvFp

Constacyclic codes are an important class of linear codes in coding theory.Many optimal linear codes are directly derived from constacyclic codes.In this paper,（1 — uv）-constacyclic codes over the local ring Fp ＋ uFp ＋ vFp ＋ uvFp are studied.It is proved that the image of a（1 — uv）-constacyclic code of length n over Fp ＋ uFp ＋ vFp ＋ uvFp under a Gray map is a distance invariant quasi-cyclic code of index p2 and length p3n over Fp.Several examples of optimal linear codes over Fp from（1 — uv）-constacyclic codes over Fp ＋ uFp ＋ vFp ＋ uvFp are given.     

2002-2012年中国林学基础研究热点分析——基于国家自然科学基金申请项目和资助项目关键词的研究

本文通过对2002-2012年国家自然科学基金委员会林学学科申请和资助项目的关键词进行共词分析,剖析了各关键词之间的关系,并借助对高频关键词的聚类分析和多维尺度分析,揭示了这11年来林学学科基础研究的热点及其内涵,探讨了目前被科学家忽视的重要科学问题.这一分析将为做好林学学科布局,促进学科均衡持续发展提供帮助.     

低共熔物中的快速卤素交换反应

在绿色化学的研究中,低共熔物越来越受到重视.利用低共熔物作为反应介质和氯离子源,以α,α-二溴代羰基化合物为原料,通过室温下的卤素交换反应,在较短的时间内,可以制备α,α-二氯代羰基化合物,二氯代产物产率为76%~85%.在低共熔物中进行的卤素交换反应,原料相对易得,反应温和,具有快速、简便等优点,比较接近绿色化学的要求.     

体育教育中引入橄榄球运动的研究

橄榄球运动可以野蛮其体魄,践行着对体育精神的追求。探讨了在学校体育教育中开展橄榄球运动的价值。通过触式橄榄球、腰旗橄榄球和定期举办校级橄榄球赛事等途径进行普及和开展,对提高中国学生的自信心更具特殊价值。     

基于小波变换和支持向量机的心电信号ST段分类

摘要: 为完成ECG(Electrocardiogram)信号特征点提取, 并对ST 段分类, 提出了一种基于离散小波变换和支持向量机的ST 分类算法。首先对信号进行预处理, 完成噪声消除, QRS 波群检测和提取特征值; 然后计算ST段平均值、曲线面积和标准差, 并结合使用SVM(Support Vector Machine)对ST段进行分类。Matlab 仿真结果表
明, 小波去噪效果明显,ST 段未出现失真现象, 特征点提取完整。经MIT鄄BIT 数据库验证, 分类结果显示交叉验证准确率平均值为80. 70%, 训练准确率平均值为91. 83%, 测试准确率平均值为74. 28%。