在土木工程专业开设建筑设计课程的思考

阐述了在土木工程专业开设建筑设计选修课的必要性;并通过分析在土木工程专业的建筑设计选修课当中所反映出来的六类问题——不接受没有教材的上课形式、缺乏美学基础、考虑问题不够全面、不会查规范、不会把握进度和抄袭现象;提出了在建筑设计课中相应采用的改进教学方法——自主辅导法、启发教学法、实证教学法、基础和规范性教学法、计划教学法和鼓励教学法,以及实施这些教学法的效果。     

Analysis of the DNA sequence and duplication history of human chromosome 15

Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplications in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.     

HPLC-ELSD测定安神宝颗粒中3种成分

为完善安神宝颗粒的质量控制标准,采用高效液相色谱法同时测定安神宝颗粒中酸枣仁皂A、东莨菪内酯、槲皮素3种有效成分,采用Agilent Zorbox SB C18色谱柱(4.6mm×150mm,5μm)及蒸发光散射检测器,柱温35℃,流动相为甲醇-0.5%的冰醋酸水溶液,梯度洗脱,流速为1.0mL/min,进样量10μL。结果表明,在该色谱条件下,3种有效成分均完全分离,峰面积对数与进样量对数呈良好的线性关系(r=0.995 6~0.998 0);精密度、重复性、稳定性试验结果符合要求,各被测组分的平均回收率在94.74%~96.08%之间。液相色谱法操作简单,准确度、灵敏度高,可用于检测安神宝颗粒中的有效成分,对完善安神宝颗粒质量标准,提升药品的质量控制水平具有实际意义。     

基于Workbench的防辐射挖掘机驾驶舱支座的有限元分析

增加了屏蔽层的防辐射驾驶舱较之原来驾驶舱增重了5.5 t,有必要对其支座的强度进行分析与校核.本文应用ANSYS Workbench对防辐射挖掘机驾驶舱支座进行有限元分析,得到其应变和应力分布情况;采取支撑板和回转平台底板加厚等措施对驾驶舱支座进行结构优化.最后对挖掘机回转平台进行模态分析,得出回转平台前十阶的固有频率和振型.模态分析为支撑座的强度设计,减少驾驶舱的振动提供了理论依据.     

可能性空间中学习过程一致收敛速度的界

在概率空间上统计学习理论是机器学习的重要组成部分.在概率空间上统计学习理论中一致收敛速度的界有重要的意义,利用经验风险最小化原则,这些界决定了学习机器的推广能力.本文在可能性空间中讨论了学习过程一致收敛速度的界,给出了一致收敛速度的界的估计并讨论了这些界和函数集容量之间的关系.     

智能工作流管理系统的设计

现存智能代理系统中存在许多问题．首先,现在绝大多数智能代理系统中所采用的推断方法效率都不高,其次,代理系统中各个子系统之间的通讯方法也不能满足需要．为得到一个更好的智能代理系统,提出了一种新的多元智能代理系统,它是传统的以知识为主体的系统与智能系统相结合的产物．另外,还提出了一种新的混合推断方法,它改进了现在普遍采用的混合推断方法．     

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.

Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and cortex. The disease is universally fatal, with a mean survival following onset of 15-20 years and, at present, there is no effective treatment. The mutation in patients with Huntington's disease is an expanded CAG/polyglutamine repeat in huntingtin, a protein of unknown function with a relative molecular mass of 350,000 (M(r) 350K). The length of the CAG/polyglutamine repeat is inversely correlated with the age of disease onset. The molecular pathways mediating the neuropathology of Huntington's disease are poorly understood. Transgenic mice expressing exon 1 of the human huntingtin gene with an expanded CAG/polyglutamine repeat develop a progressive syndrome with many of the characteristics of human Huntington's disease. Here we demonstrate evidence of caspase-1 activation in the brains of mice and humans with the disease. In this transgenic mouse model of Huntington's disease, expression of a dominant-negative caspase-1 mutant extends survival and delays the appearance of neuronal inclusions, neurotransmitter receptor alterations and onset of symptoms, indicating that caspase-1 is important in the pathogenesis of the disease. In addition, we demonstrate that intracerebroventricular administration of a caspase inhibitor delays disease progression and mortality in the mouse model of Huntington's disease.