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排序方式: 共有468条查询结果,搜索用时 15 毫秒
151.
152.
Pryor WR Rymer AM Mitchell DG Hill TW Young DT Saur J Jones GH Jacobsen S Cowley SW Mauk BH Coates AJ Gustin J Grodent D Gérard JC Lamy L Nichols JD Krimigis SM Esposito LW Dougherty MK Jouchoux AJ Stewart AI McClintock WE Holsclaw GM Ajello JM Colwell JE Hendrix AR Crary FJ Clarke JT Zhou X 《Nature》2011,472(7343):331-333
Although there are substantial differences between the magnetospheres of Jupiter and Saturn, it has been suggested that cryovolcanic activity at Enceladus could lead to electrodynamic coupling between Enceladus and Saturn like that which links Jupiter with Io, Europa and Ganymede. Powerful field-aligned electron beams associated with the Io-Jupiter coupling, for example, create an auroral footprint in Jupiter's ionosphere. Auroral ultraviolet emission associated with Enceladus-Saturn coupling is anticipated to be just a few tenths of a kilorayleigh (ref. 12), about an order of magnitude dimmer than Io's footprint and below the observable threshold, consistent with its non-detection. Here we report the detection of magnetic-field-aligned ion and electron beams (offset several moon radii downstream from Enceladus) with sufficient power to stimulate detectable aurora, and the subsequent discovery of Enceladus-associated aurora in a few per cent of the scans of the moon's footprint. The footprint varies in emission magnitude more than can plausibly be explained by changes in magnetospheric parameters--and as such is probably indicative of variable plume activity. 相似文献
153.
Somatic coding mutations in human induced pluripotent stem cells 总被引:2,自引:0,他引:2
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155.
爱德华·霍尔于 2 0 0 1年 8月 1 1日病逝 ,享年 77岁。霍尔不仅是一位伟大的物理学家 ,还是一位有独创性的发明家和手艺超群的工匠。他建造了世界上最为精确的单摆钟 ,并在科学研究上也颇有建树 ,他认为自己对科学工作纯粹都是为了兴趣而完成的。在过去的 45年里 ,霍尔的主要兴趣 (至少是在技术方面 )在考古学上。考古学主要是通过发明、建造和利用各种方法来发现古代物品 ,确定它们的年代并对其进行鉴定。考古学可以使我们了解古代的技术状况。近些年来 ,在世界范围内掀起了一场考古热 ,它是科学和艺术的结合 ,现在称为“考古定年学”。这… 相似文献
156.
LeeEunYoung 《武汉科技学院学报》2004,17(6):129-132
1.Korean Traditional CostumeKorean costume culture was originated from culture of northern horseriding tribe, Scythai culture. In Culture of Korean traditional costume, the basic type of clothing is short jacket and trousers or short jacket, skirt, and wearing hat, Wha (boots) and Lee (deep curved and low heel shoes). It was the cloak as protecting cold and taking Po for outdoor works. We can find stripe neck park of jacket and following round line in down part of sleeve. 相似文献
157.
Homozygotes for Huntington's disease 总被引:5,自引:0,他引:5
N S Wexler A B Young R E Tanzi H Travers S Starosta-Rubinstein J B Penney S R Snodgrass I Shoulson F Gomez M A Ramos Arroyo 《Nature》1987,326(6109):194-197
Careful comparison of symptomatic individuals with normal controls has revealed the primary biochemical abnormality in many human genetic diseases, particularly recessive disorders. This strategy has proved less successful for most human disorders which are not recessive, and where a single copy of the aberrant gene has clinically significant effects even though the normal gene product is present. An alternative approach that eliminates the impediment of a normal protein in affected individuals is to study homozygotes for the mutant allele. For virtually all dominant human disorders in which homozygotes have been described, symptoms have been significantly more severe in the homozygote than in the heterozygote. Thus, these disorders do not conform to the classical definition of dominance which states that homozygotes and heterozygotes for a defect are phenotypically indistinguishable. Instead, they display incomplete dominance, indicating that the normal allele may play a role in ameliorating the disease process. The D4S10 locus, defined by the probe G8 and linked to the gene for Huntington's disease (HD), has permitted us to identify individuals with a high probability of being homozygous for this autosomal dominant neurodegenerative disorder. These homozygotes do not differ in clinical expression or course from typical HD heterozygotes. HD appears to be the first human disease of genetically documented homozygosity that displays complete phenotypic dominance. 相似文献
158.
The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo. 相似文献
159.
160.
Chen Y Takita J Choi YL Kato M Ohira M Sanada M Wang L Soda M Kikuchi A Igarashi T Nakagawara A Hayashi Y Mano H Ogawa S 《Nature》2008,455(7215):971-974
Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes, including a high frequency of MYCN amplification, loss of heterozygosity at 1p36 and 11q, and gain of genetic material from 17q, all of which have been implicated in the pathogenesis of neuroblastoma. However, the scarcity of reliable molecular targets has hampered the development of effective therapeutic agents targeting neuroblastoma. Here we show that the anaplastic lymphoma kinase (ALK), originally identified as a fusion kinase in a subtype of non-Hodgkin's lymphoma (NPM-ALK) and more recently in adenocarcinoma of lung (EML4-ALK), is also a frequent target of genetic alteration in advanced neuroblastoma. According to our genome-wide scans of genetic lesions in 215 primary neuroblastoma samples using high-density single-nucleotide polymorphism genotyping microarrays, the ALK locus, centromeric to the MYCN locus, was identified as a recurrent target of copy number gain and gene amplification. Furthermore, DNA sequencing of ALK revealed eight novel missense mutations in 13 out of 215 (6.1%) fresh tumours and 8 out of 24 (33%) neuroblastoma-derived cell lines. All but one mutation in the primary samples (12 out of 13) were found in stages 3-4 of the disease and were harboured in the kinase domain. The mutated kinases were autophosphorylated and displayed increased kinase activity compared with the wild-type kinase. They were able to transform NIH3T3 fibroblasts as shown by their colony formation ability in soft agar and their capacity to form tumours in nude mice. Furthermore, we demonstrate that downregulation of ALK through RNA interference suppresses proliferation of neuroblastoma cells harbouring mutated ALK. We anticipate that our findings will provide new insights into the pathogenesis of advanced neuroblastoma and that ALK-specific kinase inhibitors might improve its clinical outcome. 相似文献