Reovirus, isolated from SARS patients

Beijing has been severely affected by SARS, and SARS-associated coronavirus has been confirmed as its cause. However, clinical and experimental evidence implicates the possibility of co-infection. In this report, reovirus was isolated from throat swabs of SARS patients, including the first case in Beijing and her mother. Identification with the electron microscopy revealed the characteristic features of reovirus. 24 of 38 samples from other SARS cases were found to have serologic responses to the reovirus. Primers designed for reovirus have amplified several fragments of DNA, one of which was sequenced (S2 gene fragment), which indicates it as a unique reovirus (orthoreovirus). Preliminary animal experiment showed that inoculation of the reovirus in mice caused death with atypical pneumonia. Nevertheless, the association of reovirus with SARS outbreak requires to be further investigated.     

基于IPSec的虚拟专用网络密钥交换实现及其安全分析

本文研究了基于IPSec结构的虚拟专用网密钥交换的基本概念和原理，详细地阐述了通过一系列参数的协商在非安全的公共IP网络中建立安全通信的密钥交换机制，给出了基于Linux系统的客户机／服务器VPN密钥交换的软件实现，对其安全特性作出了分析，指出其具有抗服务拒绝攻击，抗中间人攻击，抗连接插入攻击和防止窍听等安全性能，最后对今后研究发展的方向作了进一步的展望。     

车身NVH性能设计策略

从提高汽车NVH性能角度出发,探讨了车身结构设计、阻尼设计、密封设计、阻隔设计、补强设计、吸声设计、隔声设计、低风噪设计对车身NVH性能的影响,提出基于提高汽车NVH性能的设计方法。     

树脂改性型氯丁胶粘剂主要性能的探讨

本文主要探讨氯丁橡胶（ＣＲ）及树脂（ＲＥ）对氯丁胶粘剂性能的影响。根据正交法制备一系列配方不同的胶粘剂,并且测试其主要性能,通过数据分析,从而找出最佳配方,即选用ＣＲ０１及ＲＥ０１、ＲＥ０４可得到综合性能良好的胶粘剂     

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype; however, the precise molecular lesions and oncogenic consequences of BRCA1 dysfunction are poorly understood. Here we show that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic and BRCA1-associated hereditary breast cancers. In addition, we identify frequent gross PTEN mutations, involving intragenic chromosome breaks, inversions, deletions and micro copy number aberrations, specifically in BRCA1-deficient tumors. These data provide an example of a specific and recurrent oncogenic consequence of BRCA1-dependent dysfunction in DNA repair and provide insight into the pathogenesis of BBC with therapeutic implications. These findings also argue that obtaining an accurate census of genes mutated in cancer will require a systematic examination for gross gene rearrangements, particularly in tumors with deficient DSB repair.     

从若干高速公路路面的损坏看土壤CBR试验的重要性

高速公路路基填土CBR值不合格，是导致高速公路路面损坏的诱因，文章就此问题进行了较为详细的分析总结。     

公路边坡防护方案与生态环境保护

文章结合工程实例,论述了黄土高原温软地基采用粉喷桩施工处理时的质量控制技术总结.     

浅析改性沥青路面压实度及渗水率的控制

在实际施工中，通过有效的控制措施，保证施工路面整体压实度与渗水率指标的实现。     

自然的进化之路：系统学方法

由DNA序列构建的生物进化系统树不但可以描绘生物之问的亲缘关系，而且可以提供一个谱系背景，基于这个背景，生物各种各样性状的演化关系可以得到一定程度的说明，比如解剖学特征、行为学特征、生物态学特征、生理学特征、生物化学特征等等。所有这些都在这本书里得到了阐述。     

一类多变量传感器故障容错PID控制器的设计与应用

针对一类多变量非线性系统的传感器故障,提出了一种新型的基于神经网络模型的故障容错PID控制方法.该方法应用加权移动平均残差技术对传感器故障进行检测,并利用神经网络建模技术在线重构故障传感器信号,重组PID控制器反馈回路,实现容错PID控制.通过在三水箱过程设立多种不同类型的传感器故障,进行仿真研究.仿真研究结果表明,所提出的故障检测与容错控制策略具有很强的鲁棒性和容错能力.