Permeation study of the potassium channel from streptomyces Lividans

A three-state hopping model is established according to experiments to study permeation of an open-state potassium channel from Streptomyces Lividans (KcsA potassium channel). The master equations are used to characterize the dynamics of the system. In this model, ion conduction involves transitions of three states, with one three-ion state and two two-ion states in the selectivity filter respectively. In equilibrium, the well-known Nernst equation is deduced. It is further shown that the current follows Michaelis-Menten kinetics in steady state. According to the parameters provided by Nelson, the current-voltage relationship is proved to be ohmic and the current-concentration relationship is also obtained reasonably. Additional validation of the model in the characteristic time to reach the steady state for the potassium channel is also discussed. This model lays a possible physical basis for the permeation of ion channel, and opens an avenue for further research.     

Application and realization of hierarchical network planning based on Web

Making use of Microsoft Visual Studio. NET platform, hierarchical network planning is realized in working procedure time-optimization of the construction by TBM. and hierarchical network graph of the construction by TBM is drawn based on browser. Then the theory of system realization is discussed, six components of system that can be reused are explained emphatically. The realization of hierarchical network panning in Internet provides available guarantee for controlling rate of progress in large-scale or middle-sized projects.     

"三个代表"重要思想如何进"两课"课堂

“两课”课堂是向大学生进行“三个代表”重要思想教育的重要途径,我们不仅要使学生了解“三个代表”重要思想的科学内涵,而且要使学生深入领会其精神实质。     

吉安市农村群众体育健身点的现状调查与分析

主要采用调查法和文献资料法对江西省吉安市农村群众体育健身点的现状进行调查分析,提出了一些发展农村群众体育的建议,为更好地组织实施全民健身计划提供了参考依据.     

试论隐性城市化——江阴农村城市化道路分析

本文通过对江阴农村的实地考察,提出了隐性城市化的概念,认为农村城市化与居民点集中没有必然的联系,农村城市化的根本目的是要提高农村人民的生活水平和消灭城乡差别,在此基础上,进而对江阴农村城市化的发展方向和目前应该采取的措施作了初步探讨,在一定程度上有助于揭示我国发达地区农村城市化的某些规律和特点,对我国发达地区制定农村发展政策有一定参考价值。     

新型超导体MgB2电子结构与成键性质的第一性原理研究

对最新发现MgB2 超导体 (Tc≈ 39K)的电子结构及化学成键从能带结构、电子态密度DOS、价电子电荷密度分布等几个方面 ,采用LMTO方法进行了第一性原理研究 .同时对相关的同族二硼化物BeB2 、CaB2 电子性质的相似及差异给与阐述和比较 ,报告了SmB2 ,UB2 和LuB2 态密度的计算结果 ,并对它们的超导电性进行讨论与推测 .     

线型聚能装药射流形成过程的数值模拟

聚能射流形式过程的研究对于正确认识射流侵彻理论具有重要的意义。根据线型聚能药的结构特点,利用DYNA3D显式有限元程序对线型聚能射流的形成过程进行了数值模拟。模型探讨了线型聚能装药爆炸的诸多重要物理特性,如药型罩的压垮、射流形成和拉伸以及体杵体的“体缩”现象。还分析了线型聚能射流形成过程中速度、密度、温度等参数的分布特性,得出了射流有逆向速度梯度和杵体存在“体缩”现象听结论,其结果与现有的理论分成果基本一致。     

Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by tumors, predominantly schwannomas, in the nervous system. It is caused by mutations in the gene NF2, encoding the growth regulator schwannomin (also known as merlin). Mutations occur throughout the 17-exon gene, with most resulting in protein truncation and undetectable amounts of schwannomin protein. Pathogenic mutations that result in production of defective schwannomin include in-frame deletions of exon 2 and three independent missense mutations within this same exon. Mice with conditional deletion of exon 2 in Schwann cells develop schwannomas, which confirms the crucial nature of exon 2 for growth control. Here we report that the molecular adaptor paxillin binds directly to schwannomin at residues 50-70, which are encoded by exon 2. This interaction mediates the membrane localization of schwannomin to the plasma membrane, where it associates with beta 1 integrin and erbB2. It defines a pathogenic mechanism for the development of NF2 in humans with mutations in exon 2 of NF2.     

Coherent emission of light by thermal sources

A thermal light-emitting source, such as a black body or the incandescent filament of a light bulb, is often presented as a typical example of an incoherent source and is in marked contrast to a laser. Whereas a laser is highly monochromatic and very directional, a thermal source has a broad spectrum and is usually quasi-isotropic. However, as is the case with many systems, different behaviour can be expected on a microscopic scale. It has been shown recently that the field emitted by a thermal source made of a polar material is enhanced by more than four orders of magnitude and is partially coherent at a distance of the order of 10 to 100nm. Here we demonstrate that by introducing a periodic microstructure into such a polar material (SiC) a thermal infrared source can be fabricated that is coherent over large distances (many wavelengths) and radiates in well defined directions. Narrow angular emission lobes similar to antenna lobes are observed and the emission spectra of the source depends on the observation angle--the so-called Wolf effect. The origin of the coherent emission lies in the diffraction of surface-phonon polaritons by the grating.     

液压系统自动建模与仿真软件的研制

基于液压大系统“灰箱”建模原理与方法 ,研究开发了适用于液压大系统的自动建模与仿真软件。本文重点介绍了“灰箱”建模法的特点并应用研究软件对 15KJ电液锤液压系统进行了仿真计算